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Gap junction assembly

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-190861

PubChem

R-HSA-190861

Description

The assembly of gap junctions involves (1) synthesis of connexin polypeptides at endoplasmic reticulum membranes, (2) oligomerization into homomeric- and heteromeric gap junction connexons (hemi-channels), (3) passage through the Golgi stacks, (4) intracellular storage within Trans Golgi membranes, (5) trafficking along microtubules, (6) insertion of connexons into the plasma membrane, (7) lateral diffusion of connexons in the plasma membrane, (8) aggregation of individual gap junction channels into plaques, and (9) stabilization of peripheral microtubule plus-ends by binding to Cx43-based gap junctions (see Segretain and Falk, 2004.)

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 13 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A6NNZ2	Tubulin beta 8B	TUBB8B	view
P04350	Tubulin beta-4A chain	TUBB4 TUBB4A TUBB5	view
P68363	Tubulin alpha-1B chain	TUBA1B	view
P68366	Tubulin alpha-4A chain	TUBA1 TUBA4A	view
P68371	Tubulin beta-4B chain	TUBB2C TUBB4B	view
Q13509	Tubulin beta-3 chain	TUBB3 TUBB4	view
Q13885	Tubulin beta-2A chain	TUBB2 TUBB2A	view
Q5T442	Gap junction gamma-2 protein	GJA12 GJC2	view
Q71U36	Tubulin alpha-1A chain	TUBA1A TUBA3	view
Q9BQE3	Tubulin alpha-1C chain	TUBA1C TUBA6	view

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