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Constitutive Signaling by Aberrant PI3K in Cancer

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-2219530

PubChem

R-HSA-2219530

Description

Signaling by PI3K/AKT is frequently constitutively activated in cancer via gain-of-function mutations in one of the two PI3K subunits - PI3KCA (encoding the catalytic subunit p110alpha) or PIK3R1 (encoding the regulatory subunit p85alpha). Gain-of-function mutations activate PI3K signaling by diverse mechanisms. Mutations affecting the helical domain of PIK3CA and mutations affecting nSH2 and iSH2 domains of PIK3R1 impair inhibitory interactions between these two subunits while preserving their association. Mutations in the catalytic domain of PIK3CA enable the kinase to achieve an active conformation. PI3K complexes with gain-of-function mutations therefore produce PIP3 and activate downstream AKT in the absence of growth factors (Huang et al. 2007, Zhao et al. 2005, Miled et al. 2007, Horn et al. 2008, Sun et al. 2010, Jaiswal et al. 2009, Zhao and Vogt 2010, Urick et al. 2011).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **21 - 30** of 55 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P15153	Ras-related C3 botulinum toxin substrate 2	RAC2	view
P15391	B-lymphocyte antigen CD19	CD19	view
P15498	Proto-oncogene vav	VAV VAV1	view
P15514	Amphiregulin	AREG AREGB SDGF	view
P16234	Platelet-derived growth factor receptor alpha	PDGFR2 PDGFRA RHEPDGFRA	view
P20783	Neurotrophin-3	NTF3	view
P21781	Fibroblast growth factor 7	FGF7 KGF	view
P22455	Fibroblast growth factor receptor 4	FGFR4 JTK2 TKF	view
P23560	Neurotrophic factor BDNF precursor form	BDNF	view
P31371	Fibroblast growth factor 9	FGF9	view

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