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Loss of Nlp from mitotic centrosomes

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-380259

PubChem

R-HSA-380259

Description

During interphase, Nlp interacts with gamma-tubulin ring complexes (gamma-TuRC), and is thought to contribute to the organization of interphase microtubules (Casenghi et al.,2003). Plk1 is activated at the onset of mitosis and phosphorylates Nlp triggering its displacement from the centrosome (Casenghi et al.,2003). Removal of Nlp appears to contribute to the establishment of a mitotic scaffold with enhanced microtubule nucleation activity.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 38 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O43303	Centriolar coiled-coil protein of 110 kDa	CCP110 CEP110 CP110 KIAA0419	view
O94927	HAUS augmin-like complex subunit 5	HAUS5 KIAA0841	view
O94986	Centrosomal protein of 152 kDa	CEP152 KIAA0912	view
O95613	Pericentrin	KIAA0402 PCNT PCNT2	view
O95684	Centrosomal protein 43	CEP43 FGFR1OP FOP	view
P04350	Tubulin beta-4A chain	TUBB4 TUBB4A TUBB5	view
P07437	Tubulin beta chain	OK/SW-cl.56 TUBB TUBB5	view
P07900	Heat shock protein HSP 90-alpha	HSP90A HSP90AA1 HSPC1 HSPCA	view
P30153	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	PPP2R1A	view
P53350	Serine/threonine-protein kinase PLK1	PLK PLK1	view

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