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Recruitment of NuMA to mitotic centrosomes

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-380320

PubChem

R-HSA-380320

Description

The NuMA protein, which functions as a nuclear matrix protein in interphase (Merdes and Cleveland 1998), redistributes to the cytoplasm following nuclear envelope breakdown where it plays an essential role in formation and maintenance of the spindle poles (Gaglio, et al., 1995; Gaglio, et al., 1996; Merdes et al, 1996). The mitotic activation of NuMA involves Ran-GTP-dependent dissociation from importin (Nachury et al, 2001, Wiese et al, 2001). NuMA is transported to the mitotic poles where it forms an insoluble crescent around centrosomes tethering microtubules into the bipolar configuration of the mitotic apparatus (Merdes et al., 2000; Kisurina-Evgenieva et al, 2004). Although NuMA is not a bona fide constituent of the mitotic centrosome but rather a protein associated with microtubules at the spindle pole, specific splice variants of NuMA have been identified that associate with the centrosome during interphase (Tang et al, 1994).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A6NNZ2	Tubulin beta 8B	TUBB8B	view
O43303	Centriolar coiled-coil protein of 110 kDa	CCP110 CEP110 CP110 KIAA0419	view
O94927	HAUS augmin-like complex subunit 5	HAUS5 KIAA0841	view
O94986	Centrosomal protein of 152 kDa	CEP152 KIAA0912	view
O95613	Pericentrin	KIAA0402 PCNT PCNT2	view
O95684	Centrosomal protein 43	CEP43 FGFR1OP FOP	view
P04350	Tubulin beta-4A chain	TUBB4 TUBB4A TUBB5	view
P07437	Tubulin beta chain	OK/SW-cl.56 TUBB TUBB5	view
P07900	Heat shock protein HSP 90-alpha	HSP90A HSP90AA1 HSPC1 HSPCA	view
P30153	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	PPP2R1A	view

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