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CTNNB1 S37 mutants aren't phosphorylated

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-5358749

PubChem

R-HSA-5358749

Description

S37 mutations of beta-catenin interfere with GSK3 phosphorylation and stabilize the protein, resulting in enhanced WNT pathway signaling (Nhieu et al, 1999; Clements et al, 2002; reviewed in Polakis, 2000). S37 mutations have been identified in cancers of the brain, liver, ovary and large intestine, among others (reviewed in Polakis, 2000).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 5** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P25054	Adenomatous polyposis coli protein	APC DP2.5	view
P30153	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	PPP2R1A	view
P35222	Catenin beta-1	CTNNB CTNNB1 OK/SW-cl.35 PRO2286	view
P49841	Glycogen synthase kinase-3 beta	GSK3B	view
Q14738	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	PPP2R5D	view

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