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SHC-mediated cascade:FGFR4

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-5654719

PubChem

R-HSA-5654719

Description

The exact role of SHC1 in FGFR signaling remains unclear. Numerous studies have shown that the p46 and p52 isoforms of SHC1 are phosphorylated in response to FGF stimulation, but direct interaction with the receptor has not been demonstrated. Co-precipitation of p46 and p52 with the FGFR2 IIIc receptor has been reported, but this interaction is thought to be indirect, possibly mediated by SRC. Consistent with this, co-precipitation of SHC1 and FGFR1 IIIc is seen in mammalian cells expressing v-SRC. The p66 isoform of SHC1 has also been co-precipitated with FGFR3, but this occurs independently of receptor stimulation, and the p66 isoform not been shown to undergo FGF-dependent phosphorylation. SHC1 has been shown to associate with GRB2 and SOS1 in response to FGF stimulation, suggesting that the recruitment of SHC1 may contribute to activation of the MAPK cascade downstream of FGFR.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 10** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O43320	Fibroblast growth factor 16	FGF16	view
O76093	Fibroblast growth factor 18	FGF18 UNQ420/PRO856	view
P01111	GTPase NRas	HRAS1 NRAS	view
P01112	GTPase HRas	HRAS HRAS1	view
P10767	Fibroblast growth factor 6	FGF6 HST2 HSTF2	view
P22455	Fibroblast growth factor receptor 4	FGFR4 JTK2 TKF	view
P31371	Fibroblast growth factor 9	FGF9	view
Q07889	Son of sevenless homolog 1	SOS1	view
Q86Z14	Beta-klotho	KLB	view
Q9GZV9	Fibroblast growth factor 23	FGF23 HYPF UNQ3027/PRO9828	view

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