Purine salvage

Summary
Organism
Homo sapiens (human)
Reactome
R-HSA-74217
PubChem
R-HSA-74217
Description
  • Nucleosides and free bases generated by DNA and RNA breakdown are converted back to nucleotide monophosphates, allowing them to re-enter the pathway of purine biosynthesis and interconversion. Under normal conditions, DNA turnover is limited and deoxyribonucleotide salvage operates at a correspondingly low level (Watts 1974).
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Displaying all 6 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
P00813 Adenosine deaminase
  • ADA
  • ADA1
view
P07741 Adenine phosphoribosyltransferase
  • APRT
view
P27707 Deoxycytidine kinase
  • DCK
view
Q01433 AMP deaminase 2
  • AMPD2
view
Q16854 Deoxyguanosine kinase, mitochondrial
  • DGK
  • DGUOK
view
Q9P2T1 GMP reductase 2
  • GMPR2
view

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 6, 2026