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SARS-CoV-2 targets host intracellular signalling and regulatory pathways

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9755779

PubChem

R-HSA-9755779

Description

Severe acute respiratory syndrome coronavirus type 2 (SARS‑CoV‑2) encodes several proteins that modulate host intracellular signaling and regulatory pathways. Among them are membrane M, nucleocapsid N and 3a proteins that directly bind to host targets associated with SARS‑CoV‑2 infection and cytokine production. This Reactome module describes several such binding events and their consequences. First, SARS‑CoV‑2 M binds to 3‑phosphoinositide‑dependent protein kinase 1 (PDPK1) to inhibit PKB/Akt activation (Ren Y et al. 2021). Second, SARS‑CoV‑1 N binds to the host 14-3-3 protein, which regulates nucleocytoplasmic shuttling and other functions of N (Tugaeva KV et al. 2021). Third, binding of viral 3a to the regulator and scaffolding protein caveolin‑1 (CAV1) may regulate virus uptake as well as the trafficking of viral structural proteins (inferred from the orthologous protein in SARS-CoV-1).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 11 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O15530	3-phosphoinositide-dependent protein kinase 1	PDK1 PDPK1	view
P0DTC3	ORF3a protein	3a	view
P0DTC5	Membrane protein	M	view
P27348	14-3-3 protein theta	YWHAQ	view
P31749	RAC-alpha serine/threonine-protein kinase	AKT1 PKB RAC	view
P31751	RAC-beta serine/threonine-protein kinase	AKT2	view
P31947	14-3-3 protein sigma	HME1 SFN	view
P61981	14-3-3 protein gamma	YWHAG	view
P62258	14-3-3 protein epsilon	YWHAE	view
P63104	14-3-3 protein zeta/delta	YWHAZ	view

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