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Formation of the polybromo-BAF (pBAF) complex

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9933939

PubChem

R-HSA-9933939

Description

Mammalian pBAF (polybromo-associated BAF) complex is paralogous to the RSC (remodel the structure of chromatin) complex of S. cerevisiae (Xue et al, 2000; reviewed in Mittal and Roberts, 2020; Cenik and Shilatifard, 2021; Wang and Tang, 2023). Mammalian pBAF shares many of the same core subunits as cBAF, but is distinguished by the presence of ARID2 in place of ARID1A or B (Wang, Cote et al, 1996; Wang, Xue et al, 1996; Xue et al, 2000; Lemon et al, 2001; Yan et al, 2005; Mashtalir et al, 2018; Mashtalir et al, 2020; de Castro 2017; Wang et al, 2022; Yuan et al, 2022; Feoktistov et al, 2023). pBAF also contains unique subunits PHF10, BRD7 and PBRM (Kaeser et al, 2008; Mashtalir et al, 2018; Mashtalir et al, 2020; Wang et al, 2022; Yuan et al, 2022; reviewed in Mittal and Roberts, 2020; Cenik and Shilatifard, 2021; Innis and Cabot, 2020).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 14 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O96019	Actin-like protein 6A	ACTL6A BAF53 BAF53A INO80K	view
P51531	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2	BAF190B BRM SMARCA2 SNF2A SNF2L2	view
P51532	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4	BAF190A BRG1 SMARCA4 SNF2B SNF2L4	view
P60709	Actin, cytoplasmic 1	ACTB	view
Q12824	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1	BAF47 INI1 SMARCB1 SNF5L1	view
Q68CP9	AT-rich interactive domain-containing protein 2	ARID2 BAF200 KIAA1557	view
Q86U86	Protein polybromo-1	BAF180 PB1 PBRM1	view
Q8TAQ2	SWI/SNF complex subunit SMARCC2	BAF170 SMARCC2	view
Q92922	SWI/SNF complex subunit SMARCC1	BAF155 SMARCC1	view
Q92925	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2	BAF60B PRO2451 SMARCD2	view

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