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Formation of the embryonic stem cell BAF (esBAF) complex

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9933946

PubChem

R-HSA-9933946

Description

A distinct BAF complex has been identified in mouse and human embryonic stem cells (esBAF) (Ho, Jothi et al, 2009, Ho, Ronan et al, 2009; Zhang et al, 2014; reviewed in Kadoch and Crabtree, 2015; Cenik and Shilatifard, 2021; Innis and Cabot, 2020). esBAF is characterized by the presence of SMARCA4/BRG1 to the exclusion of SMARCA2/BRM and SMARCD1/BAF60A. Where mouse esBAF uses only SMARCC1 (BAF155), human esBAF appears to contain both SMARCC1 (BAF155) and SMARCC2 (BAF170) (Ho, Ronan et al, 2009; Ho, Jothi et al, 2009; Zhang et al, 2014; Wade et al, 2015). esBAF also contains subunits BCL11A/B (Kadoch et al, 2013; reviewed in Kadoch and Crabtree, 2015; Innis and Cabot, 2020; Cenik and Shilatifard, 2021).
esBAF colocalizes with each of the pluripotency factors, and overexpression of esBAF subunits induces pluripotency in fibroblasts (Ho, Ronan et al, 2009; Ho et al, 2011).
As the assembly of human esBAF has not been examined in detail, this pathway is based on the modular assembly of cBAF, pBAF and ncBAF (Mashtalir et al, 2018; Mashtalir et al, 2020).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 14 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O14497	AT-rich interactive domain-containing protein 1A	ARID1A BAF250 BAF250A C1orf4 OSA1 SMARCF1	view
O96019	Actin-like protein 6A	ACTL6A BAF53 BAF53A INO80K	view
P51532	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4	BAF190A BRG1 SMARCA4 SNF2B SNF2L4	view
P60709	Actin, cytoplasmic 1	ACTB	view
Q12824	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1	BAF47 INI1 SMARCB1 SNF5L1	view
Q15532	Protein SSXT	SS18 SSXT SYT	view
Q8TAQ2	SWI/SNF complex subunit SMARCC2	BAF170 SMARCC2	view
Q92922	SWI/SNF complex subunit SMARCC1	BAF155 SMARCC1	view
Q92925	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2	BAF60B PRO2451 SMARCD2	view
Q969G3	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1	BAF57 SMARCE1	view

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