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Formation of the non-canonical BAF (ncBAF) complex

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9933947

PubChem

R-HSA-9933947

Description

A non-canonical form of the BAF complex (ncBAF) was identified in mammalian cells by gradient sedimentation and by IP-mass spectrometry studies against SMARCA4 or BRD9 (Alpsoy and Dykhuizen, 2018; Gatchalian et al, 2018; Mashtalir et al, 2018; Mashtalir et al, 2020; Michel et al, 2018; reviewed in Innis and Cabot, 2020). Unlike cBAF and pBAF, ncBAF does not contain SMARCE1 or SMARCB1, nor does it contain ARID1A/ARID1B, ARID2 or any BAF45/DPF family member; ncBAF is characterized by inclusion of complex-specific subunits BIRCA or BICRAL (also known as GLTSCR1 and GLTSCR1L, respectively) and BRD9 (Alpsoy and Dykhuizen, 2018; Gatchalian et al, 2018; Mashtalir et al, 2018; Mashtalir et al, 2020; Michel et al, 2018). ncBAF localizes to CTCF binding sites and plays a role in prostate cancer, synovial sarcomas, some leukemias and and rhabdoid tumors (Michel et al, 2018; Alpsoy and Dykhuizen, 2018; Hohmann et al, 2015; reviewed in Innis and Cabot, 2020).

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SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 13 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O75177	Calcium-responsive transactivator	CREST KIAA0693 SS18L1	view
O96019	Actin-like protein 6A	ACTL6A BAF53 BAF53A INO80K	view
P51531	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2	BAF190B BRM SMARCA2 SNF2A SNF2L2	view
P51532	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4	BAF190A BRG1 SMARCA4 SNF2B SNF2L4	view
P60709	Actin, cytoplasmic 1	ACTB	view
Q15532	Protein SSXT	SS18 SSXT SYT	view
Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	BICRAL GLTSCR1L KIAA0240	view
Q8TAQ2	SWI/SNF complex subunit SMARCC2	BAF170 SMARCC2	view
Q92922	SWI/SNF complex subunit SMARCC1	BAF155 SMARCC1	view
Q92925	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2	BAF60B PRO2451 SMARCD2	view

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