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PRC2 methylates histones and DNA

Summary

Organism

Mus musculus (house mouse)

Reactome

R-MMU-212300

PubChem

R-MMU-212300

Description

This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 15 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P10853	Histone H2B type 1-F/J/L	H2b-f H2b-j H2b-l H2b-n H2bc7; H2bc11; H2bc13; H2bc15 Hist1h2bf Hist1h2bj Hist1h2bl Hist1h2bn	view
P13864	DNA (cytosine-5)-methyltransferase 1	Dnmt Dnmt1 Met1 Uim	view
P62806	Histone H4	H4-12 H4-53 H4c1; H4c2; H4c3; H4c4; H4c6; H4c8; H4c9; H4c11; H4c12; Hist1h4m; H4c14; H4c16 H4f16 Hist1h4a Hist1h4b Hist1h4c Hist1h4d Hist1h4f Hist1h4h Hist1h4i Hist1h4j Hist1h4k Hist2h4 Hist2h4a Hist4h4	view
Q60972	Histone-binding protein RBBP4	Rbap48 Rbbp4	view
Q60973	Histone-binding protein RBBP7	Rbap46 Rbbp7	view
Q61188	Histone-lysine N-methyltransferase EZH2	Enx1h Ezh2	view
Q64475	Histone H2B type 1-B	H2bc3 Hist1h2bb	view
Q64478	Histone H2B type 1-H	H2bc9 Hist1h2bh	view
Q64524	Histone H2B type 2-E	H2bc21 Hist2h2be	view
Q64525	Histone H2B type 2-B	H2bc18 Hist2h2bb	view

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