pulmonary fibrosis

Summary
Synonym
  • Fibrosis of lung
Definition
An interstitial lung disease that is characterized by destruction, scarring, and thickening of the interstitial lung tissues and progressive pulmonary function loss in a restrictive pattern, has_symptom progressive shortness of breath, fatigue, and chronic cough, possibly has_material_basis_in exposure to certain chemicals, autoimmune conditions, and radiation. It can be caused by inhaling hazardous chemicals, certain diseases, medication and genetics or unknown causes.
Super Class
interstitial lung disease
Disease Ontology
DOID:3770
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 11 - 15 of 15 in total
Gene ID Gene Symbol Description Source
7035 TFPI tissue factor pathway inhibitor
7040 TGFB1 transforming growth factor beta 1
7124 TNF tumor necrosis factor
8546 AP3B1 adaptor related protein complex 3 subunit beta 1
653509 SFTPA1 surfactant protein A1
Displaying all 5 entries
Gene ID Gene Symbol Description Source
24179 Agt angiotensinogen
24310 Ace angiotensin I converting enzyme
24617 Serpine1 serpin family E member 1
59086 Tgfb1 transforming growth factor, beta 1
83619 Nfe2l2 NFE2 like bZIP transcription factor 2

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 6, 2026