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beta galactoside alpha 2,6 sialyltransferase 1

Summary

Gene Symbol

St6gal1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20440

KEGG Gene ID

mmu:20440

PubChem

20440

Alliance of Genome Resources

MGI:108470

Annotation

Keyword

Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Phosphoprotein
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8BM62	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1 ST6Gal I Sialyltransferase 1
Q64685	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1 ST6Gal I Sialyltransferase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
N-acetylneuraminate metabolic process	ISS
N-acetylneuraminate metabolic process	ISO
N-acetylneuraminate metabolic process	IEA
protein N-linked glycosylation	ISS
protein N-linked glycosylation	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

protein modification process [inference]

protein sialylation

macromolecule modification [inference]

protein modification process [inference]

protein sialylation

sialylation

protein sialylation

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

protein modification process [inference]

protein sialylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

N-acetylneuraminate metabolic process

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis

regulation of chemotaxis [inference]

negative regulation of chemotaxis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis

regulation of chemotaxis [inference]

negative regulation of chemotaxis

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

regulation of substrate adhesion-dependent cell spreading

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

positive regulation of mononuclear cell proliferation

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of myeloid cell apoptotic process [inference]

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of macrophage apoptotic process

regulation of macrophage apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of macrophage apoptotic process

regulation of leukocyte apoptotic process [inference]

negative regulation of leukocyte apoptotic process [inference]

negative regulation of macrophage apoptotic process

regulation of macrophage apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of macrophage apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of macrophage apoptotic process

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
Golgi trans cisterna	ISO
Golgi membrane	ISS
Golgi membrane	ISO
Golgi membrane	IEA
extracellular region	ISS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

organelle membrane [inference]

Golgi cisterna membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi cisterna [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
beta-galactoside alpha-2,6-sialyltransferase activity	ISS
beta-galactoside alpha-2,6-sialyltransferase activity	ISO
beta-galactoside alpha-2,6-sialyltransferase activity	IDA
beta-galactoside alpha-2,6-sialyltransferase activity	IMP
beta-galactoside alpha-2,6-sialyltransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

sialyltransferase activity

beta-galactoside alpha-2,6-sialyltransferase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00778

Name

beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1) [EC:2.4.3.1]

References

2408023

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05990	2.4.3.1	G78059CC	G56749GV

Rhea

RHEA:52104

a β-D-galactoside + CMP-N-acetyl-β-neuraminate

an N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl derivative + H⁺ + CMP

Enzyme

2.4.3.1

PMID

RHEA:11836

N-acetyl-β-lactosamine + CMP-N-acetyl-β-neuraminate

H⁺ + N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosamine + CMP

Enzyme

2.4.3.1

PMID

RHEA:21552

a β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Cer(d18:1(4E)) + CMP-N-acetyl-β-neuraminate

H⁺ + N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide + CMP

Enzyme

2.4.3.1

PMID

2460092

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	25197	RGD:3676
Drosophila melanogaster	37950	FB:FBgn0035050
Homo sapiens	6480	HGNC:10860
Danio rerio	445376	ZFIN:ZDB-GENE-060322-3
Xenopus tropicalis	100491268	Xenbase:XB-GENE-983202