GlyCosmos Portal

Annotation

Keyword

Blood group antigen
Glycoprotein
Glycosyltransferase
Golgi apparatus
Lipid metabolism
Plastid
Proteomics identification
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P19526	Alpha(1,2)FT 1 Blood group H alpha 2-fucosyltransferase Fucosyltransferase 1 GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1 Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1 Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1
Q6IZA2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 32 in total

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GO Term	Evidence Code	PMID
regulation of endothelial cell proliferation
positive regulation of cell-matrix adhesion	IMP
carbohydrate metabolic process	TAS
carbohydrate metabolic process	IEA
lipid metabolic process

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

endoplasmic reticulum unfolded protein response

metabolic process [inference]

catabolic process [inference]

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

L-fucose catabolic process

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

L-fucose catabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via fucose

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

carbohydrate derivative biosynthetic process

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via fucose

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via fucose

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via fucose

primary metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process [inference]

L-fucose metabolic process [inference]

L-fucose catabolic process

hexose catabolic process [inference]

L-fucose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

L-fucose catabolic process

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

L-fucose catabolic process

lipid metabolic process

sphingolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via fucose

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process [inference]

L-fucose metabolic process [inference]

L-fucose catabolic process

hexose catabolic process [inference]

L-fucose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

L-fucose catabolic process

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

L-fucose catabolic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via fucose

carbohydrate derivative biosynthetic process

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via fucose

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

endothelial cell apoptotic process

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to xenobiotic stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to lipoprotein particle stimulus [inference]

cellular response to low-density lipoprotein particle stimulus

developmental process [inference]

anatomical structure development [inference]

olfactory bulb development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

response to peptide hormone [inference]

response to glucagon [inference]

cellular response to glucagon stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

response to methionine

response to xenobiotic stimulus [inference]

cellular response to xenobiotic stimulus

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

response to peptide hormone [inference]

response to glucagon [inference]

cellular response to glucagon stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to xenobiotic stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

response to nitrogen compound [inference]

response to peptide hormone [inference]

response to glucagon [inference]

cellular response to glucagon stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

response to methionine

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose [inference]

cellular response to glucose stimulus

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

response to peptide hormone [inference]

response to glucagon [inference]

cellular response to glucagon stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

response to methionine

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to xenobiotic stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to glucagon stimulus

cellular response to lipoprotein particle stimulus [inference]

cellular response to low-density lipoprotein particle stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion

positive regulation of endothelial cell-matrix adhesion

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

endoplasmic reticulum unfolded protein response

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of lipid catabolic process [inference]

regulation of triglyceride catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of lipid catabolic process [inference]

regulation of triglyceride catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of cell adhesion

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion [inference]

positive regulation of cell-matrix adhesion

positive regulation of endothelial cell-matrix adhesion

regulation of endothelial cell-matrix adhesion [inference]

positive regulation of endothelial cell-matrix adhesion

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion

positive regulation of endothelial cell-matrix adhesion

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion

positive regulation of endothelial cell-matrix adhesion

regulation of cell population proliferation [inference]

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

regulation of endothelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion

positive regulation of endothelial cell-matrix adhesion

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
obsolete extracellular space
Golgi apparatus	TAS
Golgi apparatus	IBA
Golgi apparatus	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

Golgi cisterna membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
galactoside 2-alpha-L-fucosyltransferase activity	TAS
galactoside 2-alpha-L-fucosyltransferase activity	IBA
galactoside 2-alpha-L-fucosyltransferase activity	IEA
fucosyltransferase activity	TAS
fucosyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

fucosyltransferase activity

alpha-(1,2)-fucosyltransferase activity

galactoside 2-alpha-L-fucosyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg001

Gene Symbol

FUT1

Reactions

Displaying **all 3** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
GDP-Fuc	G00055MO	Free	G61459JW	Free	2118655
GDP-Fuc	G11042HO	R	G57920AK	R	10814703
GDP-Fuc	G00056MO	Free	G40696TO	Free	2118655

Displaying **all 4** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
GDP-Fuc	G00055MO	Free	G61459JW	Free	2118655
GDP-Fuc	G11042HO	R	G57920AK	R	10814703
GDP-Fuc	G00056MO	Free	G40696TO	Free	2118655
GDP-Fuc	G17173XA	O-glycan Synthesis	G45304XA	O-glycan Synthesis

Orthologous Gene

Displaying **all 3** entries
Species	Protein	mRNA
Caenorhabditis elegans	NP_492814	NM_060413
Mus musculus	NP_032077	NM_008051
Rattus norvegicus	NP_112515	NM_031236

KEGG BRITE Database

Orthology

K00718

Name

galactoside 2-L-fucosyltransferase 1/2 [EC:2.4.1.69]

References

Reactions

Displaying entries **1 - 10** of 12 in total

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KEGG Reaction	Enzyme	Acceptor	Product
R06090	2.4.1.69	G28261RX	G87164WU
R06170	2.4.1.69	G56390QA	G63238VS
R06024	2.4.1.69	G58896AZ	G13636IT
R06035	2.4.1.69	G84034JH	G66427ZQ
R06085	2.4.1.69	G98726UE	G98900YM
R06089	2.4.1.69	G98726UE	G28261RX
R05968	2.4.1.69	G99053DY	G98465JN
R06041	2.4.1.69	G33816GC	G59724US
R06031	2.4.1.69	G64885AH	G58990QD
R06156	2.4.1.69	G00049MO	G00050MO

Rhea

RHEA:32175

a β-D-Gal-(1→3)-β-D-GlcNAc-(1→3)-β-D-Gal-(1→4)-β-D-Glc-(1↔1ʼ)-Cer(d18:1(4E)) + GDP-β-L-fucose

H⁺ + α-L-fucosyl-(1→2)- β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1ʼ)-N-acylsphing-4-enine + GDP

Enzyme

2.4.1.69

PMID

RHEA:50668

a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + GDP-β-L-fucose

an α-L-Fuc-(1→2)-β-D-Gal-(1→4)-β-D-GlcNAc derivative + H⁺ + GDP

Enzyme

2.4.1.344

PMID

RHEA:50664

a β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl derivative + GDP-β-L-fucose

an α-L-Fuc-(1→2)-β-D-Gal-(1→3)-β-D-GlcNAc derivative + H⁺ + GDP

Enzyme

2.4.1.69

PMID

Disease

PubChem Disease

MedGen Diseases

Bombay phenotype

OMIM Phenotypes

BOMBAY PHENOTYPE

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002339
Gene Name: fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	14343	MGI:109375
Rattus norvegicus	81919	RGD:2638
Xenopus laevis	398668	Xenbase:XB-GENE-986120
Xenopus laevis	108696766	Xenbase:XB-GENE-17335422
Xenopus tropicalis	447958	Xenbase:XB-GENE-986117

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements