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insulin receptor

Summary

Gene Symbol

INSR

Aliases

CD220

Organism

Homo sapiens (human)

External Links

NCBI Gene

3643

HGNC

6091

PubChem

3643

Alliance of Genome Resources

HGNC:6091

JoGo

INSR

TogoVar

INSR

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Carbohydrate metabolism
Cell membrane
Cleavage on pair of basic residues
Diabetes mellitus
Direct protein sequencing
Disease variant
Disulfide bond
Endosome
Glycoprotein
Isopeptide bond
Lysosome
Phosphoprotein
Proteomics identification
Receptor
Reference proteome
Repeat
S-nitrosylation
Signal
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P06213

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 67 in total

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GO Term	Evidence Code	PMID
positive regulation of receptor internalization	IDA
heart morphogenesis	IMP
regulation of glycogen biosynthetic process	IEA
regulation of DNA-templated transcription	IMP
regulation of transcription, DNA-templated	IMP

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway

insulin receptor signaling pathway

G protein-coupled receptor signaling pathway

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

protein autophosphorylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

receptor internalization

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection organization [inference]

dendritic spine organization [inference]

dendritic spine maintenance

neuron projection maintenance

cellular component maintenance [inference]

dendritic spine maintenance

postsynapse organization [inference]

dendritic spine organization [inference]

dendritic spine maintenance

reproductive process [inference]

developmental process involved in reproduction [inference]

sex determination [inference]

male sex determination

reproductive structure development [inference]

gonad development [inference]

male gonad development

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

nervous system process [inference]

cognition [inference]

learning or memory [inference]

behavior [inference]

learning or memory [inference]

amyloid-beta clearance

developmental process [inference]

developmental process involved in reproduction [inference]

sex determination [inference]

male sex determination

reproductive structure development [inference]

gonad development [inference]

male gonad development

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

heart morphogenesis

anatomical structure development [inference]

tissue development [inference]

epidermis development

animal organ development

gonad development [inference]

male gonad development

gland development [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

system development

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

symbiont entry into host [inference]

symbiont entry into host cell

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to growth factor [inference]

cellular response to growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to growth factor stimulus

response to chemical [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to nitrogen compound [inference]

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to oxygen-containing compound [inference]

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

vascular transport [inference]

transport across blood-brain barrier

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

receptor internalization

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

receptor internalization

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

regulation of D-glucose import across plasma membrane [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

positive regulation of receptor internalization

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

regulation of growth [inference]

positive regulation of growth [inference]

positive regulation of developmental growth

regulation of developmental growth [inference]

positive regulation of developmental growth

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of growth [inference]

positive regulation of developmental growth

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitric oxide biosynthetic process

positive regulation of catabolic process [inference]

positive regulation of nucleotide catabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of nucleotide metabolic process [inference]

positive regulation of nucleotide catabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of purine nucleotide metabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of ATP metabolic process [inference]

positive regulation of glycolytic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of glycolytic process

positive regulation of respiratory burst

positive regulation of small molecule metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of nucleotide metabolic process [inference]

positive regulation of nucleotide catabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of purine nucleotide metabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of ATP metabolic process [inference]

positive regulation of glycolytic process

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of cell cycle [inference]

positive regulation of meiotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of mitotic nuclear division

positive regulation of cellular component organization

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division

positive regulation of protein-containing complex disassembly

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

positive regulation of developmental process [inference]

positive regulation of developmental growth

positive regulation of reproductive process [inference]

positive regulation of meiotic cell cycle

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of developmental process [inference]

regulation of developmental growth [inference]

positive regulation of developmental growth

positive regulation of developmental process [inference]

positive regulation of developmental growth

regulation of gonad development [inference]

regulation of female gonad development

regulation of multicellular organismal development [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway

insulin receptor signaling pathway

G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitric oxide biosynthetic process

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of polysaccharide biosynthetic process [inference]

regulation of glucan biosynthetic process [inference]

regulation of glycogen biosynthetic process

positive regulation of glycogen biosynthetic process

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of carbohydrate biosynthetic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of glucan biosynthetic process [inference]

regulation of glycogen biosynthetic process

positive regulation of glycogen biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitric oxide biosynthetic process

positive regulation of catabolic process [inference]

positive regulation of nucleotide catabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of nucleotide metabolic process [inference]

positive regulation of nucleotide catabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of purine nucleotide metabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of ATP metabolic process [inference]

positive regulation of glycolytic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of glycolytic process

positive regulation of respiratory burst

positive regulation of small molecule metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of nucleotide metabolic process [inference]

positive regulation of nucleotide catabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of purine nucleotide metabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of ATP metabolic process [inference]

positive regulation of glycolytic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of nucleotide catabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

regulation of nucleotide catabolic process [inference]

positive regulation of nucleotide catabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process [inference]

positive regulation of glycolytic process

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

regulation of carbohydrate catabolic process [inference]

regulation of glycolytic process [inference]

positive regulation of glycolytic process

regulation of generation of precursor metabolites and energy [inference]

regulation of glycolytic process [inference]

positive regulation of glycolytic process

regulation of glycogen metabolic process [inference]

regulation of glycogen biosynthetic process

positive regulation of glycogen biosynthetic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen biosynthetic process

regulation of phosphorus metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide catabolic process [inference]

positive regulation of nucleotide catabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process [inference]

positive regulation of glycolytic process

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of nucleotide metabolic process [inference]

positive regulation of nucleotide catabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of purine nucleotide metabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of ATP metabolic process [inference]

positive regulation of glycolytic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process [inference]

positive regulation of glycolytic process

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of purine nucleotide metabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of ATP metabolic process [inference]

positive regulation of glycolytic process

regulation of ATP metabolic process [inference]

regulation of glycolytic process [inference]

positive regulation of glycolytic process

positive regulation of ATP metabolic process [inference]

positive regulation of glycolytic process

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of nucleotide metabolic process [inference]

positive regulation of nucleotide catabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of purine nucleotide metabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of ATP metabolic process [inference]

positive regulation of glycolytic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of polysaccharide biosynthetic process [inference]

regulation of glucan biosynthetic process [inference]

regulation of glycogen biosynthetic process

positive regulation of glycogen biosynthetic process

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen biosynthetic process

regulation of polysaccharide metabolic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of glucan biosynthetic process [inference]

regulation of glycogen biosynthetic process

positive regulation of glycogen biosynthetic process

regulation of glycogen metabolic process [inference]

regulation of glycogen biosynthetic process

positive regulation of glycogen biosynthetic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen biosynthetic process

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of respiratory burst [inference]

positive regulation of respiratory burst

regulation of small molecule metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide catabolic process [inference]

positive regulation of nucleotide catabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process [inference]

positive regulation of glycolytic process

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of nucleotide metabolic process [inference]

positive regulation of nucleotide catabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of purine nucleotide metabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of ATP metabolic process [inference]

positive regulation of glycolytic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process [inference]

positive regulation of glycolytic process

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of purine nucleotide metabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of ATP metabolic process [inference]

positive regulation of glycolytic process

regulation of ATP metabolic process [inference]

regulation of glycolytic process [inference]

positive regulation of glycolytic process

positive regulation of ATP metabolic process [inference]

positive regulation of glycolytic process

regulation of glucose metabolic process

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of nucleotide metabolic process [inference]

positive regulation of nucleotide catabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of purine nucleotide metabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of ATP metabolic process [inference]

positive regulation of glycolytic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen biosynthetic process

regulation of polysaccharide metabolic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of glucan biosynthetic process [inference]

regulation of glycogen biosynthetic process

positive regulation of glycogen biosynthetic process

regulation of glycogen metabolic process [inference]

regulation of glycogen biosynthetic process

positive regulation of glycogen biosynthetic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen biosynthetic process

regulation of carbohydrate biosynthetic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of glucan biosynthetic process [inference]

regulation of glycogen biosynthetic process

positive regulation of glycogen biosynthetic process

regulation of carbohydrate catabolic process [inference]

regulation of glycolytic process [inference]

positive regulation of glycolytic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of glycolytic process

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide catabolic process [inference]

positive regulation of nucleotide catabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process [inference]

positive regulation of glycolytic process

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of nucleotide metabolic process [inference]

positive regulation of nucleotide catabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of purine nucleotide metabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of ATP metabolic process [inference]

positive regulation of glycolytic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process [inference]

positive regulation of glycolytic process

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of purine nucleotide metabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of ATP metabolic process [inference]

positive regulation of glycolytic process

regulation of ATP metabolic process [inference]

regulation of glycolytic process [inference]

positive regulation of glycolytic process

positive regulation of ATP metabolic process [inference]

positive regulation of glycolytic process

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of nitric oxide metabolic process [inference]

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of transmembrane transport [inference]

regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

regulation of D-glucose import across plasma membrane [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitric oxide biosynthetic process

positive regulation of catabolic process [inference]

positive regulation of nucleotide catabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of nucleotide metabolic process [inference]

positive regulation of nucleotide catabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of purine nucleotide metabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of ATP metabolic process [inference]

positive regulation of glycolytic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of glycolytic process

positive regulation of respiratory burst

positive regulation of small molecule metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen biosynthetic process

positive regulation of nucleotide metabolic process [inference]

positive regulation of nucleotide catabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of purine nucleotide metabolic process [inference]

positive regulation of purine nucleotide catabolic process [inference]

positive regulation of glycolytic process

positive regulation of ATP metabolic process [inference]

positive regulation of glycolytic process

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of cell cycle [inference]

positive regulation of meiotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of mitotic nuclear division

positive regulation of cellular component organization

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division

positive regulation of protein-containing complex disassembly

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

positive regulation of receptor internalization

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division

regulation of nuclear division [inference]

regulation of mitotic nuclear division [inference]

positive regulation of mitotic nuclear division

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division

regulation of protein-containing complex disassembly [inference]

positive regulation of protein-containing complex disassembly

positive regulation of cellular component organization

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division

positive regulation of protein-containing complex disassembly

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic nuclear division [inference]

positive regulation of mitotic nuclear division

regulation of cell cycle process [inference]

regulation of mitotic nuclear division [inference]

positive regulation of mitotic nuclear division

positive regulation of cell cycle process [inference]

positive regulation of mitotic nuclear division

positive regulation of cell cycle [inference]

positive regulation of meiotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of mitotic nuclear division

regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

positive regulation of receptor internalization

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of multicellular organismal process

regulation of multicellular organismal development [inference]

regulation of reproductive process [inference]

regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle

regulation of gonad development [inference]

regulation of female gonad development

positive regulation of reproductive process [inference]

positive regulation of meiotic cell cycle

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GO Term	Evidence Code	PMID
nuclear envelope	IDA
lysosome	ISS
lysosome	IEA
late endosome	ISS
late endosome	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

plasma membrane signaling receptor complex [inference]

insulin receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

insulin receptor complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

protein kinase complex [inference]

insulin receptor complex

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

dendrite membrane

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

leading edge membrane [inference]

neuron projection membrane [inference]

dendrite membrane

organelle envelope [inference]

nuclear envelope

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

nuclear lumen

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

cell body

neuronal cell body

cell body membrane [inference]

neuronal cell body membrane

side of membrane [inference]

external side of plasma membrane

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GO Term	Evidence Code	PMID
amyloid-beta binding	IPI
protein kinase activity	IEA
protein tyrosine kinase activity	EXP
protein tyrosine kinase activity	IDA
protein tyrosine kinase activity	IMP

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

insulin receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

insulin receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

insulin receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

insulin receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

insulin receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

insulin receptor activity

structural molecule activity

binding [inference]

protein binding

signaling receptor binding [inference]

insulin-like growth factor receptor binding

growth factor binding [inference]

insulin-like growth factor binding [inference]

protein domain specific binding

PTB domain binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

peptide binding [inference]

amyloid-beta binding

hormone binding [inference]

peptide hormone binding [inference]

insulin binding

protein-containing complex binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

GTP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

cargo receptor activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

insulin receptor activity

protein-hormone receptor activity [inference]

insulin receptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity

kinase regulator activity [inference]

kinase activator activity [inference]

protein kinase activator activity

protein kinase regulator activity [inference]

protein kinase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

insulin receptor a

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

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Gene Ontology
ATP binding
insulin receptor activity
insulin receptor substrate binding
kinase activity
nucleotide binding
phosphorylation
positive regulation of MAPK cascade
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
transferase activity
transmembrane receptor protein tyrosine kinase activity

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InterPro
Fibronectin type III superfamily
Fibronectin type III
Furin-like cysteine-rich domain
Furin-like repeat
Growth factor receptor cysteine-rich domain superfamily
Immunoglobulin-like fold
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Receptor L-domain superfamily

Rhea

RHEA:10596

ATP

H⁺ + ADP

Enzyme

PMID

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0050470	Donohue syndrome	Alliance of Genome Resources
DOID:0070220	familial hyperinsulinemic hypoglycemia 5	Alliance of Genome Resources
DOID:11714	gestational diabetes	Alliance of Genome Resources
DOID:2526	prostate adenocarcinoma	Alliance of Genome Resources
DOID:3594	choriocarcinoma	Alliance of Genome Resources
DOID:9351	diabetes mellitus	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000040	Long penis
HP:0000065	Labial hypertrophy
HP:0000105	Enlarged kidney
HP:0000121	Nephrocalcinosis
HP:0000138	Ovarian cyst
HP:0000154	Wide mouth
HP:0000158	Macroglossia
HP:0000164	Abnormality of the dentition

Displaying **all 7** entries
Disease ID	Disease Name
OMIM:262190	Rabson-Mendenhall syndrome
ORPHA:263458	hyperinsulinism due to INSR deficiency
ORPHA:769	Rabson-Mendenhall syndrome
OMIM:609968	hyperinsulinism due to INSR deficiency
ORPHA:508	Donohue syndrome
ORPHA:2297	insulin-resistance syndrome type A
OMIM:246200	Donohue syndrome

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

ChIP-Atlas

Target Genes: Predicted target genes bound by given transcription factors. Target Genes
Potential target genes for INSR
Distance from TSS: ± 10 kb

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Gene Symbol	Description	Cellline (score)
OPA1	OPA1 mitochondrial dynamin like GTPase	SH-SY5Y(140)
RAC3	Rac family small GTPase 3	Hep_G2(121)
PMM2	phosphomannomutase 2	Hep_G2(157) Hep_G2(74)
RAB1A	RAB1A, member RAS oncogene family	Hep_G2(131) Hep_G2(203) Hep_G2(239) Hep_G2(285) SH-SY5Y(130)
FASN	fatty acid synthase	Hep_G2(120)
KHK	ketohexokinase	Hep_G2(217) Hep_G2(331) Hep_G2(341) Hep_G2(434) SH-SY5Y(219)
DNM1L	dynamin 1 like	Hep_G2(110) Hep_G2(169) Hep_G2(211) Hep_G2(89) SH-SY5Y(102)
SMUG1	single-strand-selective monofunctional uracil-DNA glycosylase 1	Hep_G2(172) Hep_G2(195) Hep_G2(91) SH-SY5Y(143)
EIF5B	eukaryotic translation initiation factor 5B	Hep_G2(123) Hep_G2(141) Hep_G2(198) Hep_G2(314)
CHPF2	chondroitin polymerizing factor 2	Hep_G2(105) Hep_G2(201) Hep_G2(225) Hep_G2(240) SH-SY5Y(336)

Colocalization: Predicted partner proteins colocalizing with given transcription factors. Colocalization
Colocalization analysis for INSR

Displaying **all 6** entries
Gene Symbol	Description	Cellline (score)
DCP1A	decapping mRNA 1A	SH-EP(0)
SMCHD1	structural maintenance of chromosomes flexible hinge domain containing 1	SH-SY5Y(0) SH-SY5Y(4) SH-SY5Y(9) hTERT_RPE-1(0)
INO80	INO80 complex ATPase subunit	Hep_G2(0) HuH-7(0)
MBD4	methyl-CpG binding domain 4, DNA glycosylase	Hep_G2(0)
HDAC2	histone deacetylase 2	Hep_G2(0) U-87_MG(0)
INSR	insulin receptor	Hep_G2(10) Hep_G2(9) SH-SY5Y(10) SH-SY5Y(9)

An integrative, comprehensive database to explore public Epigenetic dataset, including ChIP-Seq, DNase-Seq, ATAC-Seq, and Bisulfite-Seq data: ChIP-Atlas covers almost all public data archived in Sequence Read Archive of NCBI, EBI, and DDBJ with over 224,000 experiments.

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

PubChem Disease

International Collaboration

Acknowledgements