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decapping mRNA 1A

Summary

Gene Symbol

DCP1A

Aliases

HSA275986
SMAD4IP1
SMIF

Organism

Homo sapiens (human)

External Links

NCBI Gene

55802

HGNC

18714

KEGG Gene ID

[""]

PubChem

55802

Alliance of Genome Resources

HGNC:18714

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Hydrolase
Methylation
Nonsense-mediated mRNA decay
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NPI6	Smad4-interacting transcriptional co-activator Transcription factor SMIF

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	NAS
deadenylation-dependent decapping of nuclear-transcribed mRNA	NAS
deadenylation-dependent decapping of nuclear-transcribed mRNA	IBA
deadenylation-dependent decapping of nuclear-transcribed mRNA	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA methylguanosine-cap decapping

RNA decapping [inference]

mRNA methylguanosine-cap decapping

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA methylguanosine-cap decapping

RNA decapping [inference]

mRNA methylguanosine-cap decapping

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to cytoplasmic stress granule

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of biological quality [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
P-body	ISS
P-body	NAS
P-body	IBA
P-body	IEA
nucleus	EXP

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

P-body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

P-body

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

P-body

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
mRNA binding	IBA
protein binding	IPI
enzyme activator activity	IEA
kinesin binding	IEA
identical protein binding	IPI

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity

binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

mRNA binding

protein binding

cytoskeletal protein binding [inference]

kinesin binding

identical protein binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity

molecular function activator activity [inference]

enzyme activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

mRNA-decapping enzyme

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
deadenylation-dependent decapping of nuclear-transcribed mRNA
deadenylation-independent decapping of nuclear-transcribed mRNA

Displaying **all 3** entries
InterPro
PH-like domain superfamily
mRNA-decapping enzyme subunit 1
mRNA-decapping enzyme, C-terminal

Rhea

RHEA:67484

H₂O

H⁺ + N⁷-methyl-GDP

Enzyme

3.6.1.62

PMID

ChIP-Atlas

Target Genes: Predicted target genes bound by given transcription factors. Target Genes
Potential target genes for DCP1A
Distance from TSS: ± 10 kb

Displaying entries **1 - 10** of **260** in total

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Gene Symbol	Description	Cellline (score)
LPIN3	lipin 3	HeLa(183)
ATAD2	ATPase family AAA domain containing 2	HeLa(323) SH-EP(87)
EXT2	exostosin glycosyltransferase 2	SH-EP(165) SH-EP(96)
AGA	aspartylglucosaminidase	HeLa(266) SH-EP(159)
SPAG1	sperm associated antigen 1	HeLa(162)
GLA	galactosidase alpha	HeLa(173)
UGCG	UDP-glucose ceramide glucosyltransferase	HeLa(209) SH-EP(117)
MGAT2	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	HeLa(405)
ADPRS	ADP-ribosylserine hydrolase	HeLa(266) SH-EP(184)
ACP4	acid phosphatase 4	HeLa(213)

Colocalization: Predicted partner proteins colocalizing with given transcription factors. Colocalization
Colocalization analysis for DCP1A

Displaying **all 7** entries
Gene Symbol	Description	Cellline (score)
DCP1A	decapping mRNA 1A	HeLa(10) SH-EP(0) SH-EP(10)
HDAC9	histone deacetylase 9	SK-UT-1(0)
HDAC2	histone deacetylase 2	U-87_MG(0)
INSR	insulin receptor	SH-SY5Y(0)
SMCHD1	structural maintenance of chromosomes flexible hinge domain containing 1	SH-SY5Y(0) hTERT_RPE-1(0)
MORC2	MORC family CW-type zinc finger 2	HeLa(0)
HDAC4	histone deacetylase 4	SK-UT-1(0)

An integrative, comprehensive database to explore public Epigenetic dataset, including ChIP-Seq, DNase-Seq, ATAC-Seq, and Bisulfite-Seq data: ChIP-Atlas covers almost all public data archived in Sequence Read Archive of NCBI, EBI, and DDBJ with over 224,000 experiments.

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OrthoDB (Group)

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Acknowledgements