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MORC family CW-type zinc finger 2

Summary

Gene Symbol

MORC2

Aliases

AC004542.C22.1
KIAA0852
ZCW3

Organism

Homo sapiens (human)

External Links

NCBI Gene

22880

HGNC

23573

KEGG Gene ID

[""]

PubChem

22880

Alliance of Genome Resources

HGNC:23573

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Charcot-Marie-Tooth disease
Chromosome
Coiled coil
Cytoplasm
Disease variant
Dwarfism
Fatty acid metabolism
Hydrolase
Intellectual disability
Isopeptide bond
Magnesium
Neurodegeneration
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Ubl conjugation
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y6X9	MORC family CW-type zinc finger protein 2 Zinc finger CW-type coiled-coil domain protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
chromatin remodeling	IDA
fatty acid metabolic process
cellular response to DNA damage stimulus	IDA
DNA damage response	IDA
constitutive heterochromatin formation	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

fatty acid metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization [inference]

chromatin remodeling

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation

transposable element silencing by heterochromatin formation

heterochromatin organization [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation

transposable element silencing by heterochromatin formation

cellular component assembly [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation

transposable element silencing by heterochromatin formation

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

transposable element silencing [inference]

transposable element silencing by heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation

transposable element silencing by heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

transposable element silencing [inference]

transposable element silencing by heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation

transposable element silencing by heterochromatin formation

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

transposable element silencing [inference]

transposable element silencing by heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation

transposable element silencing by heterochromatin formation

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

transposable element silencing [inference]

transposable element silencing by heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation

transposable element silencing by heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation

transposable element silencing by heterochromatin formation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

transposable element silencing [inference]

transposable element silencing by heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation

transposable element silencing by heterochromatin formation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

transposable element silencing [inference]

transposable element silencing by heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation

transposable element silencing by heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

transposable element silencing [inference]

transposable element silencing by heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation

transposable element silencing by heterochromatin formation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

transposable element silencing [inference]

transposable element silencing by heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation

transposable element silencing by heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation

transposable element silencing by heterochromatin formation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

transposable element silencing [inference]

transposable element silencing by heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation

transposable element silencing by heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

transposable element silencing [inference]

transposable element silencing by heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation

transposable element silencing by heterochromatin formation

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

transposable element silencing [inference]

transposable element silencing by heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation

transposable element silencing by heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

transposable element silencing [inference]

transposable element silencing by heterochromatin formation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation

transposable element silencing by heterochromatin formation

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
heterochromatin	IDA
nucleus	EXP
nucleus	IDA
nucleus	IBA
nucleus	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

chromatin [inference]

heterochromatin

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

chromosome

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GO Term	Evidence Code	PMID
magnesium ion binding	IDA
chromatin binding	IDA
protein binding	IPI
ATP binding	IDA
zinc ion binding	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

ATP-dependent chromatin remodeler activity

binding [inference]

chromatin binding

protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

transition metal ion binding [inference]

zinc ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

ATP-dependent activity [inference]

ATP-dependent activity, acting on DNA [inference]

ATP-dependent chromatin remodeler activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

morc family cw-type zinc finger

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
zinc ion binding

Displaying **all 3** entries
InterPro
Histidine kinase/HSP90-like ATPase superfamily
MICRORCHIDIA ATPase family
Morc, S5 domain 2-like

Human Protein Atlas

ENSG00000133422

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110181	Charcot-Marie-Tooth disease axonal type 2Z	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000020	Urinary incontinence
HP:0000252	Microcephaly
HP:0000365	Hearing impairment
HP:0000467	Neck muscle weakness
HP:0000518	Cataract
HP:0000580	Pigmentary retinopathy
HP:0000750	Delayed speech and language development
HP:0001047	Atopic dermatitis
HP:0001171	Split hand

Displaying **all 3** entries
Disease ID	Disease Name
OMIM:616688	Charcot-Marie-Tooth disease axonal type 2Z
OMIM:619090	developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy
ORPHA:466768	Charcot-Marie-Tooth disease axonal type 2Z

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

ChIP-Atlas

Target Genes: Predicted target genes bound by given transcription factors. Target Genes
Potential target genes for MORC2
Distance from TSS: ± 10 kb

Displaying entries **1 - 10** of 46 in total

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Gene Symbol	Description	Cellline (score)
MBD4	methyl-CpG binding domain 4, DNA glycosylase	HeLa(564) HeLa(644) HeLa(647) HeLa(681)
B3GALNT1	beta-1,3-N-acetylgalactosaminyltransferase 1 (Globoside blood group)	Embryonic_Stem_Cells(187)
ABHD13	abhydrolase domain containing 13	Embryonic_Stem_Cells(115)
NGLY1	N-glycanase 1	K-562(128) K-562(199)
ALG8	ALG8 alpha-1,3-glucosyltransferase	Embryonic_Stem_Cells(100) K-562(113) K-562(177)
MTMR7	myotubularin related protein 7	Embryonic_Stem_Cells(120)
PLOD1	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	HeLa(369) HeLa(416) HeLa(430) HeLa(459)
COLGALT1	collagen beta(1-O)galactosyltransferase 1	HeLa(186)
DCP1A	decapping mRNA 1A	HeLa(97)
SLC35A3	solute carrier family 35 member A3	HeLa(74)

Colocalization: Predicted partner proteins colocalizing with given transcription factors. Colocalization
Colocalization analysis for MORC2

Displaying **all 9** entries
Gene Symbol	Description	Cellline (score)
DCP1A	decapping mRNA 1A	HeLa(0)
MORC2	MORC family CW-type zinc finger 2	Embryonic_Stem_Cells(10) Embryonic_Stem_Cells(9) HeLa(10) HeLa(9) K-562(0) K-562(10) K-562(4)
HDAC4	histone deacetylase 4	MM.1S(0) SK-UT-1(0)
HDAC9	histone deacetylase 9	SK-UT-1(0)
WRNIP1	WRN helicase interacting protein 1	GM12878(0)
INO80	INO80 complex ATPase subunit	CD4-Positive_T-Lymphocytes(0) SK-MEL-147(0)
HDAC2	histone deacetylase 2	CD4-Positive_T-Lymphocytes(0) Embryonic_Stem_Cells(0) Erythroid_progenitors(0) HL-60(0) K-562(0) Kasumi-1(0) MM.1S(0) Pre-B_cells(0) hESC_H1(0) iPS_cells(0) iPS_derived_cardiac_cells(0)
MTHFD1	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	HAP1(0)
HDAC3	histone deacetylase 3	Acute_myeloid_leukemia(0) CD4-Positive_T-Lymphocytes(0) MM.1S(0)

An integrative, comprehensive database to explore public Epigenetic dataset, including ChIP-Seq, DNase-Seq, ATAC-Seq, and Bisulfite-Seq data: ChIP-Atlas covers almost all public data archived in Sequence Read Archive of NCBI, EBI, and DDBJ with over 224,000 experiments.

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External Links

Annotation

OrthoDB (Group)

PubChem Disease

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Acknowledgements