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histone deacetylase 3
Summary
- Gene Symbol
-
- HDAC3
- Aliases
-
- HD3
- KDAC3
- RPD3
- RPD3-2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Biological rhythms
- Chromatin regulator
- Chromosome
- Cytoplasm
- Host-virus interaction
- Hydrolase
- Nucleus
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Repressor
- Transcription regulation
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| O15379 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of transcription by RNA polymerase II |
|
|
| negative regulation of transcription by RNA polymerase II |
|
|
| establishment of mitotic spindle orientation |
|
|
| in utero embryonic development |
|
|
| positive regulation of protein phosphorylation |
|
GO Hierarchy
- regulation of circadian rhythm
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of signaling [inference]
regulation of localization [inference]
regulation of protein localization [inference]
regulation of transport [inference]
regulation of cellular localization [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
negative regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
negative regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
negative regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of programmed cell death [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cellular localization [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| histone deacetylase complex |
|
|
| histone deacetylase complex |
|
|
| histone deacetylase complex |
|
|
| chromatin |
|
|
| nucleus |
|
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| transcription corepressor binding |
|
|
| DNA binding |
|
|
| chromatin binding |
|
|
| chromatin binding |
|
|
| transcription corepressor activity |
|
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Histone deacetylase
- Functional Category
-
- J: Translation, ribosomal structure and biogenesis
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| histone deacetylase activity |
| metal ion binding |
| InterPro |
|---|
| Histone deacetylase domain superfamily |
| Histone deacetylase domain |
| Histone deacetylase family |
| Histone deacetylase |
| Ureohydrolase domain superfamily |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:3908 | lung non-small cell carcinoma |
ChIP-Atlas
- Target Genes
-
Predicted target genes bound by given transcription factors. Target Genes
Potential target genes for HDAC3
Distance from TSS: ± 10 kb
| Gene Symbol | Description | Cellline (score) |
|---|---|---|
| beta 3-glucosyltransferase |
|
|
| N-acetylneuraminic acid phosphatase |
|
|
| ST3 beta-galactoside alpha-2,3-sialyltransferase 6 |
|
|
| beta-1,4-galactosyltransferase 3 |
|
|
| alpha-1,4-N-acetylglucosaminyltransferase |
|
|
| glycerophosphodiester phosphodiesterase domain containing 3 |
|
|
| heparan sulfate-glucosamine 3-sulfotransferase 3A1 |
|
|
| dCMP deaminase |
|
|
| GDP-D-glucose phosphorylase 1 |
|
|
| lysophospholipase 2 |
|
- Colocalization
-
Predicted partner proteins colocalizing with given transcription factors. Colocalization
Colocalization analysis for HDAC3
| Gene Symbol | Description | Cellline (score) |
|---|---|---|
| INO80 complex ATPase subunit |
|
|
| histone deacetylase 4 |
|
|
| methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 |
|
|
| histone deacetylase 3 |
|
|
| WRN helicase interacting protein 1 |
|
|
| histone deacetylase 2 |
|
|
| MORC family CW-type zinc finger 2 |
|
