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methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1

Summary

Gene Symbol

MTHFD1

Organism

Homo sapiens (human)

External Links

NCBI Gene

4522

HGNC

7432

PubChem

4522

Alliance of Genome Resources

HGNC:7432

JoGo

MTHFD1

TogoVar

MTHFD1

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Cytoplasm
Direct protein sequencing
Disease variant
Hydrolase
Ligase
Multifunctional enzyme
NADP
One-carbon metabolism
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
F5H2F4
P11586	Epididymis secretory sperm binding protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
neutrophil homeostasis	IEA
neural tube closure	ISS
neural tube closure	IEA
purine nucleotide biosynthetic process	ISS
purine nucleotide biosynthetic process	IMP

GO Hierarchy

biological process

immune system process [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

cellular process [inference]

metabolic process [inference]

modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid-containing compound biosynthetic process [inference]

tetrahydrofolate biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

tetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate biosynthetic process

tetrahydrofolate interconversion

tetrahydrofolate biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

folic acid metabolic process

modified amino acid biosynthetic process [inference]

folic acid-containing compound biosynthetic process [inference]

tetrahydrofolate biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

sulfur compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

L-methionine biosynthetic process

L-methionine metabolic process

L-methionine biosynthetic process

homocysteine metabolic process [inference]

transsulfuration

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

L-methionine biosynthetic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organophosphate biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

L-methionine biosynthetic process

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

modified amino acid biosynthetic process [inference]

folic acid-containing compound biosynthetic process [inference]

tetrahydrofolate biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

pteridine-containing compound biosynthetic process [inference]

folic acid-containing compound biosynthetic process [inference]

tetrahydrofolate biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

L-methionine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

L-methionine biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

L-methionine biosynthetic process

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

L-methionine biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

organophosphate biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid-containing compound biosynthetic process [inference]

tetrahydrofolate biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

tetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate biosynthetic process

tetrahydrofolate interconversion

tetrahydrofolate biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

folic acid metabolic process

pteridine-containing compound biosynthetic process [inference]

folic acid-containing compound biosynthetic process [inference]

tetrahydrofolate biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

L-methionine biosynthetic process

proteinogenic amino acid metabolic process [inference]

L-methionine metabolic process

L-methionine biosynthetic process

transsulfuration

proteinogenic amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

L-methionine biosynthetic process

non-proteinogenic amino acid metabolic process [inference]

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid metabolic process [inference]

homocysteine metabolic process [inference]

transsulfuration

L-amino acid metabolic process [inference]

L-methionine metabolic process

L-methionine biosynthetic process

transsulfuration

L-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

L-methionine biosynthetic process

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

L-methionine biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

L-methionine biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

L-methionine biosynthetic process

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

L-methionine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

L-methionine biosynthetic process

L-methionine metabolic process

L-methionine biosynthetic process

homocysteine metabolic process [inference]

transsulfuration

dicarboxylic acid metabolic process [inference]

10-formyltetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

folic acid metabolic process

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

L-methionine biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

L-methionine biosynthetic process

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

L-methionine biosynthetic process

proteinogenic amino acid metabolic process [inference]

L-methionine metabolic process

L-methionine biosynthetic process

transsulfuration

proteinogenic amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

L-methionine biosynthetic process

non-proteinogenic amino acid metabolic process [inference]

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid metabolic process [inference]

homocysteine metabolic process [inference]

transsulfuration

L-amino acid metabolic process [inference]

L-methionine metabolic process

L-methionine biosynthetic process

transsulfuration

L-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

L-methionine biosynthetic process

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

L-methionine biosynthetic process

one-carbon metabolic process [inference]

tetrahydrofolate interconversion

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

L-methionine biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

L-methionine biosynthetic process

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

L-methionine biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

somite development

animal organ development [inference]

heart development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

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GO Term	Evidence Code	PMID
cytoplasm	IEA
mitochondrion	TAS
cytosol	TAS
cytosol	IDA
cytosol	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
catalytic activity	IEA
formate-tetrahydrofolate ligase activity	ISS
formate-tetrahydrofolate ligase activity	IDA
formate-tetrahydrofolate ligase activity	IMP
formate-tetrahydrofolate ligase activity	IEA

GO Hierarchy

molecular function

catalytic activity

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-NH group of donors [inference]

oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [inference]

methylenetetrahydrofolate dehydrogenase (NADP+) activity

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [inference]

cyclohydrolase activity [inference]

methenyltetrahydrofolate cyclohydrolase activity

ligase activity [inference]

ligase activity, forming carbon-nitrogen bonds [inference]

formate-tetrahydrofolate ligase activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

C-1-tetrahydrofolate synthase, cytoplasmic

Functional Category

E: Amino acid transport and metabolism
F: Nucleotide transport and metabolism
H: Coenzyme transport and metabolism

Displaying **all 6** entries
Gene Ontology
ATP binding
catalytic activity
formate-tetrahydrofolate ligase activity
methenyltetrahydrofolate cyclohydrolase activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
tetrahydrofolate interconversion

Displaying **all 8** entries
InterPro
Aminoacid dehydrogenase-like, N-terminal domain superfamily
Formate-tetrahydrofolate ligase, FTHFS, conserved site
Formate-tetrahydrofolate ligase, FTHFS
NAD(P)-binding domain superfamily
P-loop containing nucleoside triphosphate hydrolase
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
Tetrahydrofolate dehydrogenase/cyclohydrolase

Human Protein Atlas

ENSG00000100714

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0080016	spina bifida	Alliance of Genome Resources
DOID:0080074	neural tube defect	Alliance of Genome Resources
DOID:0080633	developmental cardiac valvular defect	Alliance of Genome Resources
DOID:14250	Down syndrome	Alliance of Genome Resources
DOID:6419	tetralogy of Fallot	Alliance of Genome Resources
DOID:674	cleft palate	Alliance of Genome Resources
DOID:7693	abdominal aortic aneurysm	Alliance of Genome Resources
DOID:9296	cleft lip	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000365	Hearing impairment
HP:0000964	Eczematoid dermatitis
HP:0001250	Seizure
HP:0001256	Intellectual disability, mild
HP:0001876	Pancytopenia
HP:0001888	Lymphopenia
HP:0001889	Megaloblastic anemia
HP:0001894	Thrombocytosis
HP:0001939	Abnormality of metabolism/homeostasis

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:601634	neural tube defects, folate-sensitive
OMIM:617780	combined immunodeficiency and megaloblastic anemia with or without hyperhomocysteinemia

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Neural tube defects, folate-sensitive

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

ChIP-Atlas

Target Genes: Predicted target genes bound by given transcription factors. Target Genes
Potential target genes for MTHFD1
Distance from TSS: ± 10 kb

Displaying 1 entry
Gene Symbol	Description	Cellline (score)
UGT1A4	UDP glucuronosyltransferase family 1 member A4	HAP1(215)

Colocalization: Predicted partner proteins colocalizing with given transcription factors. Colocalization
Colocalization analysis for MTHFD1

Displaying **all 7** entries
Gene Symbol	Description	Cellline (score)
INO80	INO80 complex ATPase subunit	CD4-Positive_T-Lymphocytes(0) SK-MEL-147(0)
HDAC2	histone deacetylase 2	CD4-Positive_T-Lymphocytes(0) Erythroid_progenitors(0) HL-60(0) K-562(0) Kasumi-1(0) MM.1S(0) Pre-B_cells(0)
HDAC4	histone deacetylase 4	MM.1S(0)
HDAC3	histone deacetylase 3	Acute_myeloid_leukemia(0) CD4-Positive_T-Lymphocytes(0) MM.1S(0)
MTHFD1	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	HAP1(10) HAP1(9)
WRNIP1	WRN helicase interacting protein 1	GM12878(0)
MORC2	MORC family CW-type zinc finger 2	K-562(0)

An integrative, comprehensive database to explore public Epigenetic dataset, including ChIP-Seq, DNase-Seq, ATAC-Seq, and Bisulfite-Seq data: ChIP-Atlas covers almost all public data archived in Sequence Read Archive of NCBI, EBI, and DDBJ with over 224,000 experiments.

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Summary

External Links

Annotation

OrthoDB (Group)

PubChem Disease

International Collaboration

Acknowledgements