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glucosaminyl (N-acetyl) transferase 4

Summary

Gene Symbol

GCNT4

Aliases

C2GNT3
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4
core 2 beta-1,6-N-acetylglucosaminyltransferase 3

Organism

Homo sapiens (human)

External Links

NCBI Gene

51301

GGDB ID

gg110

HGNC

17973

mRNA

NM_016591

map

5q12

Protein

NP_057675

OMIM

616782

KEGG Gene ID

hsa:51301

PubChem

51301

Alliance of Genome Resources

HGNC:17973

JoGo

GCNT4

TogoVar

GCNT4

Annotation

Keyword

Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Proteomics identification
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9P109	Core 2-branching enzyme 3 Core2-GlcNAc-transferase 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
neutrophil homeostasis
inter-male aggressive behavior
carbohydrate metabolic process	TAS
protein O-linked glycosylation	TAS
protein O-linked glycosylation via N-acetyl-galactosamine	TAS

GO Hierarchy

biological process

immune system process [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

cellular process [inference]

metabolic process [inference]

modified amino acid metabolic process [inference]

thyroid hormone metabolic process

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via N-acetyl-galactosamine

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via N-acetyl-galactosamine

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process

hormone metabolic process [inference]

thyroid hormone metabolic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via N-acetyl-galactosamine

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via N-acetyl-galactosamine

primary metabolic process [inference]

carbohydrate metabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via N-acetyl-galactosamine

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via N-acetyl-galactosamine

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation

protein O-linked glycosylation via N-acetyl-galactosamine

multicellular organismal process [inference]

behavior [inference]

aggressive behavior [inference]

inter-male aggressive behavior

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

kidney morphogenesis

tissue morphogenesis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

thyroid hormone metabolic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
Golgi membrane	TAS
Golgi membrane	IEA
Golgi apparatus	IDA
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity	TAS
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity	IEA
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity	TAS
UDP-glycosyltransferase activity	IEA
acetylglucosaminyltransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

UDP-glycosyltransferase activity

acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

beta-1 3-galactosyl-O-glycosyl-glycoprotein beta-1 6-N-acetylglucosaminyltransferase

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
acetylglucosaminyltransferase activity
transferase activity

Displaying 1 entry
InterPro
Glycosyl transferase, family 14

Human Protein Atlas

ENSG00000176928

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg110

Gene Symbol

GCNT4

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G00031MO	Ser/Thr	G00033MO	Ser/Thr	10753916

Displaying **all 5** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G00031MO	[alpha]-1-benzyl	G00033MO	[alpha]-1-benzyl	10753916
UDP-GlcNAc	G00031MO	[alpha]	G00033MO	[alpha]	10753916
UDP-GlcNAc	G00031MO	[alpha]-1-p-nitrophenyl	G00033MO	[alpha]-1-p-nitrophenyl	10753916
UDP-GlcNAc	G00031MO	[alpha]-1-methylumbelliferyl	G00033MO	[alpha]-1-methylumbelliferyl	10753916
UDP-GlcNAc	G00031MO	Ser/Thr	G00033MO	Ser/Thr	10753916

Displaying entries **1 - 5** of 6 in total

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Donor	Acceptor	Reducing terminal(Acceptor)	Reference
UDP-GlcNAc	G57321FI	[alpha]-1-p-nitrophenyl	10753916
UDP-GlcNAc	G00035MO	[alpha]-1-p-nitrophenyl	10753916
UDP-GlcNAc	G00049MO	Cer	10753916
UDP-GlcNAc	G33476GF	[beta]-1-methyl	10753916
UDP-GlcNAc	G57321FI		10753916

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Mus musculus	XP_138797	XM_138797
Rattus norvegicus	XP_226703	XM_226703

KEGG BRITE Database

Orthology

K09663

Name

beta-1,6-N-acetylglucosaminyltransferase 4 [EC:2.4.1.-]

References

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05912	2.4.1.102	G00031MO	G00033MO

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	218476	MGI:2684919
Caenorhabditis elegans	173114	WB:WBGene00001640
Caenorhabditis elegans	173109	WB:WBGene00001641
Danio rerio	324510	ZFIN:ZDB-GENE-030131-3231
Xenopus tropicalis	100492495	Xenbase:XB-GENE-1011770

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements