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MIRAGE
glucosaminyl (N-acetyl) transferase 3, mucin type

Summary
Gene Symbol
  • GCNT3
Aliases
  • C2/4GnT
  • C2GnT-M
  • C2GnT2
Organism
Homo sapiens (human)
NCBI Gene
9245
GGDB ID
HGNC
4205
mRNA
map
  • 15q21.3
Protein
OMIM
KEGG Gene ID
hsa:9245
PubChem
9245
Alliance of Genome Resources
Annotation
Keyword
  • Disulfide bond
  • Glycoprotein
  • Glycosyltransferase
  • Golgi apparatus
  • Proteomics identification
  • Reference proteome
  • Signal-anchor
  • Transmembrane helix
Proteins
Displaying 1 entry
UniProt Protein Name
O95395
  • C2GnT-mucin type
  • Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 6 in total
GO Term Evidence Code PMID
carbohydrate metabolic process
protein O-linked glycosylation
O-glycan processing
tissue morphogenesis
intestinal absorption
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
beta-1,3-galactosyl-o-glycosyl-glycoprotein beta-1,6-n-acetylglucosaminyltransferase
Functional Category
  • M: Cell wall/membrane/envelope biogenesis
  • O: Posttranslational modification, protein turnover, chaperones
  • T: Signal transduction mechanisms
Displaying 1 entry
Gene Ontology
transferase activity
Human Protein Atlas
ENSG00000140297

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas
GlycoGene Database (GGDB)
GGDB ID
gg108
Gene Symbol
  • GCNT3
Reactions
Displaying all 3 entries
Donor Acceptor Reducing terminal(Acceptor) Product Reducing terminal(Product) Reference
UDP-GlcNAc
G00035MO
Ser/Thr
G00037MO
Ser/Thr
UDP-GlcNAc
G00031MO
Ser/Thr
G00033MO
Ser/Thr
UDP-GlcNAc
G29487JS
Ser/Thr
G08872UM
Ser/Thr
Displaying entries 6 - 9 of 9 in total
Donor Acceptor Reducing terminal(Acceptor) Product Reducing terminal(Product) Reference
UDP-GlcNAc
G00035MO
[alpha]-1-p-nitrophenyl
G00037MO
[alpha]-1-p-nitrophenyl
UDP-GlcNAc
G00031MO
[alpha]-pNP
G00033MO
[alpha]-pNP
UDP-GlcNAc
G00031MO
Ser/Thr
G00033MO
Ser/Thr
UDP-GlcNAc
G29487JS
Ser/Thr
G08872UM
Ser/Thr
Displaying all 4 entries
Donor Acceptor Reducing terminal(Acceptor) Reference
UDP-GlcNAc
G57321FI
UDP-GlcNAc
G33476GF
methyl
UDP-GlcNAc
G58896AZ
Cer
UDP-GlcNAc
G57321FI
[alpha]-1-p-nitrophenyl
Orthologous Gene
Displaying all 2 entries
Species Protein mRNA
Mus musculus NP_082363 NM_028087
Rattus norvegicus NP_775434 NM_173312
KEGG BRITE Database
Orthology
K09662
Name
N-acetylglucosaminyltransferase 3, mucin type [EC:2.4.1.-]
References
Reactions
Displaying all 2 entries
KEGG Reaction Enzyme Acceptor Product
R05915
R05912
Rhea

RHEA:17413

a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + UDP-N-acetyl-α-D-glucosamine
an N-acetyl-β-D-glucosaminyl-(1→6)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + H+ + UDP
Enzyme
PMID

RHEA:56212

UDP-N-acetyl-α-D-glucosamine
H+ + UDP
Enzyme
PMID

RHEA:54820

a β-D-Gal-(1→4)-β-D-GlcNAc-(1→3)-β-D-Gal-(1→4)-β-D-GlcNAc derivative + UDP-N-acetyl-α-D-glucosamine
a β-D-Gal-(1→4)-β-D-GlcNAc-(1→3)-[β-D-GlcNAc-(1→6)]-β-D-Gal-(1→4)-N-acetyl-β-D-glucosaminyl derivative + H+ + UDP
Enzyme
PMID

RHEA:56192

UDP-N-acetyl-α-D-glucosamine
H+ + UDP
Enzyme
PMID

RHEA:56216

UDP-N-acetyl-α-D-glucosamine
H+ + UDP
Enzyme
PMID

RHEA:56188

UDP-N-acetyl-α-D-glucosamine
H+ + UDP
Enzyme
PMID
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP006286
Gene Name
glucosaminyl (N-acetyl) transferase 3, mucin type
Ortholog
Displaying entries 81 - 90 of 113 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
108229946 KRYMA03252
108229947 KRYMA03253
108712473 Xenbase:XB-GENE-990817
108712954 Xenbase:XB-GENE-5887146
109079111 CYPCA143353
109085803 CYPCA139772
109202906 ORENI69683
109202907 ORENI69682
111228715 SERDU10552
111718498 SARHA15620
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025