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MIRAGE
G00059MO

Summary
GlyTouCan ID
G00059MO
IUPAC Condensed
Gal(a1-4)Gal(b1-4)Glc(b1-
Motifs
Gb3 Pk antigen globotriaosylceramide
Subsumption Level
Fully-defined saccharide
Monoisotopic Mass
504.17
GlyGen
ChEBI
PubChem Compound
PubChem Substance
3D Structures
GlycoNAVI
G00059MO
GLYCAM
DGalpa1-4DGalpb1-4DGlcpb1-OH
GlycoShape
G00059MO
Displaying 1 entry
Archetype α β
G67710XV
G79094AA
G00059MO
Organisms
Displaying entries 6 - 10 of 16 in total
Organisms Evidence
Rattus
Haemophilus influenzae
Homo sapiens (human)
Canis lupus familiaris (dog)
Leishmania amazonensis
Taxonomic Hierarchy
GlycoGene Database (GGDB)
Displaying 1 entry
Gene Symbol Donor Acceptor Reducing terminal(Acceptor) Product Reducing terminal(Product) Reference
A4GALT UDP-Gal
G84224TW
Cer
G00059MO
Cer
Displaying all 2 entries
Gene Symbol Donor Acceptor Reducing terminal(Acceptor) Product Reducing terminal(Product) Reference
A4GALT UDP-Gal
G84224TW
Cer
G00059MO
Cer
B3GALNT1 UDP-GalNAc
G00059MO
Cer
G00061MO
Cer
Displaying all 5 entries
Gene Symbol Donor Acceptor Reducing terminal(Acceptor) Reference
B3GALT4 UDP-Gal
G00059MO
Cer
B4GALT3 UDP-Gal
G00059MO
Cer
B3GALT1 UDP-Gal
G00059MO
Cer
B3GALT2 UDP-Gal
G00059MO
Cer
B3GALNT2 UDP-GalNAc
G00059MO
Cer
KEGG BRITE Database
KEGG ID
Enzyme
References
Reactions
Displaying all 4 entries
KEGG Reaction Enzyme Acceptor Product
R05962
R05961
R05963
R05960
GlycoEpitope
Epitope ID
EP0071
Sequence Descriptors
GlycoCT
RES
1b:b-dglc-HEX-1:5
2b:b-dgal-HEX-1:5
3b:a-dgal-HEX-1:5
LIN
1:1o(4+1)2d
2:2o(4+1)3d
WURCS
WURCS=2.0/3,3,2/[a2122h-1b_1-5][a2112h-1b_1-5][a2112h-1a_1-5]/1-2-3/a4-b1_b4-c1
Literature
Displaying entries 21 - 30 of 61 in total
PubMed ID Title First Author Publication Date Source
23722161 Target-selective photo-degradation of verotoxin-1 and reduction of its cytotoxicity to Vero cells using porphyrin–globotriose hybrids Okochi A 2013 Jul 11
  • PubChem
22372889 Synthesis and Assessment of Globotriose–Chitosan Conjugate, a Novel Inhibitor of Shiga Toxins Produced by Escherichia coli Li X 2012 Mar 08
  • PubChem
22083453 MRP1 Expressed on Burkitt’s Lymphoma Cells was Depleted by Catfish Egg Lectin Through Gb3-Glycosphingolipid and Enhanced Cytotoxic Effect of Drugs Fujii Y 2011 Nov 12
  • PubChem
19674101 A novel, promoter-based, target-specific assay identifies 2-deoxy-D-glucose as an inhibitor of globotriaosylceramide biosynthesis Okuda T 2009 Aug 27
  • GlyGen
  • GlycoEpitope
19524596 Structure of Rhamnose-binding Lectin CSL3: Unique Pseudo-tetrameric Architecture of a Pattern Recognition Protein Shirai T 2009 Aug 14
  • PubChem
18398881 Globotriose‐Functionalized Gold Nanoparticles as Multivalent Probes for Shiga‐like Toxin Chien YY 2008 Apr 28
  • PubChem
17106997 Globotriose- and Oligo(ethylene glycol)-Terminated Self-Assembled Monolayers: Surface Forces, Wetting, and Surfactant Adsorption Blomberg E 2006 Oct 25
  • PubChem
16495579 Structural Analysis of the Interaction between Shiga Toxin B Subunits and Linear Polymers Bearing Clustered Globotriose Residues Watanabe M 2006 Mar
  • PubChem
16903672 Carbosilane Dendrimers Bearing Globotriaoses: Construction of a Series of Carbosilane Dendrimers Bearing Globotriaoses Matsuoka K 2006 Jun 28
  • PubChem
16903671 Carbosilane Dendrimers Bearing Globotriaoses: Syntheses of Globotrioasyl Derivative and Introduction into Carbosilane Dendrimers Matsuoka K 2006 Jun 28
  • PubChem
PubAnnotation
Displaying entries 1 - 5 of 7 in total
Title Authors Source Publication Date PubMed ID
Single-mutations at the galactose-binding site of enzymes GalK, GalU, and LgtC enable the efficient synthesis of UDP-6-azido-6-deoxy-d-galactose and azido-functionalized Gb3 analogs.
  • Ortiz-Soto ME
  • Baier M
  • Brenner D
  • Timm M
  • Seibel J
 Glycobiology 2023 Oct 6 37283491
Glucosylceramide synthase inhibitors differentially affect expression of glycosphingolipids.
  • Alam S
  • Fedier A
  • Kohler RS
  • Jacob F
 Glycobiology 2015 Apr 25715344
Multiplex tandem mass spectrometry analysis of novel plasma lyso-Gb₃-related analogues in Fabry disease.
  • Boutin M
  • Auray-Blais C
 Anal Chem 2014 Apr 1 24634980
Cholesterol masks membrane glycosphingolipid tumor-associated antigens to reduce their immunodetection in human cancer biopsies.
  • Novak A
  • Binnington B
  • Ngan B
  • Chadwick K
  • Fleshner N
  • Lingwood CA
 Glycobiology 2013 Nov 23906628
Ceramide glycosylation by glucosylceramide synthase selectively maintains the properties of breast cancer stem cells.
  • Gupta V
  • Bhinge KN
  • Hosain SB
  • Xiong K
  • Gu X
  • Shi R
  • Ho MY
  • Khoo KH
  • Li SC
  • Li YT
  • Ambudkar SV
  • Jazwinski SM
  • Liu YY
 J Biol Chem 2012 Oct 26 22936806
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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