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G46677TE

Summary

GlyTouCan ID: G46677TE
IUPAC Condensed: Neu5Ac(a2-3)[Neu5Ac(a2-3)Gal(b1-3)GalNAc(b1-4)]Gal(b1-4)Glc(b1-
Motifs: GD1a
Subsumption Level: Fully-defined saccharide
Monoisotopic Mass: 1289.44

External Links

GlyGen

G46677TE

ChEBI

59209

PubChem Compound

45266861

PubChem Substance

252282546

GlycoShape

Displaying 1 entry
Archetype	α	β
G21518JT	G01633SK	G46677TE

3D Structures

GlycoShape: G46677TE
GLYCAM: Neup5Aca2-3[Neup5Aca2-3DGalpb1-3DGalpNAcb1-4]DGalpb1-4DGlcpb1-OH

Organisms

Displaying entries **1 - 5** of 20 in total

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Organisms	Evidence
Oncorhynchus mykiss (rainbow trout)	GlyTouCan(glycome-db)
Meleagris gallopavo (turkey)	GlyTouCan(glycome-db)
Mus musculus (house mouse)	GlyTouCan(glycome-db)
Cricetulus griseus (Chinese hamster)	GlyTouCan(glycome-db)
Gallus gallus (chicken)	GlyTouCan(glycome-db)

Taxonomic Hierarchy

root

cellular organisms [inference]

Eukaryota (eucaryotes) [inference]

Opisthokonta [inference]

Metazoa (metazoans) [inference]

Eumetazoa [inference]

Bilateria [inference]

Deuterostomia [inference]

Chordata (chordates) [inference]

Craniata [inference]

Vertebrata (vertebrates) [inference]

Gnathostomata (jawed vertebrates) [inference]

Teleostomi [inference]

Euteleostomi (bony vertebrates) [inference]

Actinopterygii (ray-finned fishes) [inference]

Actinopteri [inference]

Neopterygii [inference]

Teleostei (teleost fishes) [inference]

Osteoglossocephalai [inference]

Clupeocephala [inference]

Euteleosteomorpha [inference]

Protacanthopterygii [inference]

Salmoniformes (salmons and trouts) [inference]

Salmonidae (salmonids) [inference]

Salmoninae (trouts, salmons & chars) [inference]

Oncorhynchus [inference]

Oncorhynchus mykiss (rainbow trout)

Neoteleostei [inference]

Eurypterygia [inference]

Ctenosquamata [inference]

Acanthomorphata [inference]

Euacanthomorphacea [inference]

Percomorphaceae [inference]

Carangaria [inference]

Pleuronectiformes (flatfishes) [inference]

Pleuronectoidei [inference]

Pleuronectidae (righteye flounders) [inference]

Parophrys [inference]

Parophrys vetulus (English sole)

Ovalentaria [inference]

Cichlomorphae [inference]

Cichliformes (cichlids and convict blennies) [inference]

Cichlidae (cichlids)

Otomorpha [inference]

Ostariophysi [inference]

Otophysi [inference]

Cypriniphysae [inference]

Cypriniformes (carps and others) [inference]

Cyprinoidei [inference]

Cyprinidae [inference]

Cyprininae [inference]

Carassius [inference]

Carassius auratus (goldfish)

Sarcopterygii [inference]

Dipnotetrapodomorpha [inference]

Tetrapoda (tetrapods) [inference]

Amniota (amniotes) [inference]

Sauropsida (sauropsids) [inference]

Sauria (diapsids) [inference]

Archelosauria [inference]

Archosauria [inference]

Dinosauria [inference]

Saurischia [inference]

Theropoda [inference]

Coelurosauria [inference]

Aves (birds) [inference]

Neognathae [inference]

Galloanserae [inference]

Galliformes (landfowls) [inference]

Phasianidae (turkeys) [inference]

Meleagridinae [inference]

Meleagris [inference]

Meleagris gallopavo (turkey)

Phasianinae [inference]

Gallus [inference]

Gallus gallus (chicken)

Mammalia (mammals) [inference]

Theria [inference]

Eutheria (placentals) [inference]

Boreoeutheria [inference]

Laurasiatheria [inference]

Artiodactyla (even-toed ungulates & whales) [inference]

Ruminantia [inference]

Pecora [inference]

Bovidae [inference]

Bovinae [inference]

Bos (cattle) [inference]

Bos taurus (domestic cattle)

Suina [inference]

Suidae (pigs) [inference]

Sus [inference]

Sus scrofa (pig)

Whippomorpha [inference]

Cetacea (whales) [inference]

Odontoceti (tooth whales) [inference]

Delphinidae (marine dolphins) [inference]

Tursiops [inference]

Tursiops truncatus (common bottlenose dolphin)

Carnivora (carnivores) [inference]

Feliformia [inference]

Felidae (cat family) [inference]

Felinae [inference]

Felis [inference]

Felis catus (domestic cat)

Eulipotyphla (hedgehogs, shrews, moles and others) [inference]

Soricidae (shrews)

Euarchontoglires [inference]

Glires (Rodents and rabbits) [inference]

Rodentia (rodent) [inference]

Myomorpha (mice and others) [inference]

Muroidea [inference]

Muridae [inference]

Murinae [inference]

Rattus

Mus (mice) [inference]

Mus [inference]

Mus musculus (house mouse)

Cricetidae [inference]

Cricetinae (hamsters)

Cricetulus [inference]

Cricetulus griseus (Chinese hamster)

Hystricomorpha (guinea pigs and others) [inference]

Chinchillidae (chinchillas)

Lagomorpha [inference]

Leporidae (rabbits and hares) [inference]

Oryctolagus [inference]

Oryctolagus cuniculus (rabbit)

Primates [inference]

Haplorrhini [inference]

Simiiformes [inference]

Catarrhini [inference]

Cercopithecoidea [inference]

Cercopithecidae (Old World monkeys) [inference]

Cercopithecinae [inference]

Papio (baboons) [inference]

Papio hamadryas (hamadryas baboon)

Hominoidea (apes) [inference]

Hominidae (great apes) [inference]

Homininae [inference]

Homo [inference]

Homo sapiens (human)

Discoba [inference]

Euglenozoa [inference]

Kinetoplastea (kinetoplasts) [inference]

Metakinetoplastina [inference]

Trypanosomatida [inference]

Trypanosomatidae [inference]

Leishmaniinae [inference]

Leishmania [inference]

Leishmania mexicana species complex [inference]

Leishmania amazonensis

GlycoGene Database (GGDB)

Displaying 1 entry
Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
ST8SIA5	CMP-Neu5Ac	G46677TE	Cer	G68110IF	Cer	8910600

Displaying entries **1 - 5** of 6 in total

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Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
ST8SIA5	CMP-Neu5Ac	G46677TE	Cer	G68110IF	Cer	8910600
ST8SIA5	CMP-Neu5Ac	G46677TE	Cer	G40183QN	Cer	9199191
ST8SIA6	CMP-Neu5Ac	G46677TE	Cer	G40183QN	Cer	11980897 16120058
ST3GAL2	CMP-Neu5Ac	G48558GR	Cer	G46677TE	Cer	8920913
ST3GAL1	CMP-Neu5Ac	G48558GR	ceramide	G46677TE	ceramide	8027041

Displaying entries **1 - 5** of 6 in total

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Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Reference
ST6GALNAC2	CMP-Neu5Ac	G46677TE	ceramide	11062056
ST6GALNAC4	CMP-Neu5Ac	G46677TE	ceramide	11062056
ST8SIA2	CMP-Neu5Ac	G46677TE	Cer	7782326
ST3GAL6	CMP-Neu5Ac	G46677TE	ceramide	10206952
ST8SIA3	CMP-Neu5Ac	G46677TE	Cer	7782326 8910600

KEGG BRITE Database

KEGG ID

G00111

Enzyme

References

Reactions

Displaying **all 3** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05943	2.4.99.-	G46677TE	G68110IF
R05942	2.4.3.2	G48558GR	G46677TE
R05945		G46677TE	G02149VR

GlycoEpitope

Epitope ID: EP0056
Epitope Name: GD1a

Sequence Descriptors

GlycoCT

RES
1b:b-dglc-HEX-1:5
2b:b-dgal-HEX-1:5
3b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
4s:n-acetyl
5b:b-dgal-HEX-1:5
6s:n-acetyl
7b:b-dgal-HEX-1:5
8b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
9s:n-acetyl
LIN
1:1o(4+1)2d
2:2o(3+2)3d
3:3d(5+1)4n
4:2o(4+1)5d
5:5d(2+1)6n
6:5o(3+1)7d
7:7o(3+2)8d
8:8d(5+1)9n

WURCS

WURCS=2.0/4,6,5/[a2122h-1b_1-5][a2112h-1b_1-5][Aad21122h-2a_2-6_5*NCC/3=O][a2112h-1b_1-5_2*NCC/3=O]/1-2-3-4-2-3/a4-b1_b3-c2_b4-d1_d3-e1_e3-f2

Literature

Displaying entries **31 - 40** of 45 in total

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PubMed ID	Title	First Author	Publication Date	Source
8866432	Post-infectious encephalitis with anti-galactocerebroside antibody subsequent to Mycoplasma pneumoniae infection	Nishimura M	1996 Sep 01	PubChem
8910600	Molecular cloning and expression of a fifth type of alpha2,8-sialyltransferase (ST8Sia V). Its substrate specificity is similar to that of SAT-V/III, which synthesize GD1c, GT1a, GQ1b and GT3	Kono M	1996 Nov 15	PubChem
8920913	Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II)	Kim YJ	1996 Nov 12	PubChem
8654583	Antigen binding of antiganglioside antibodies in vitro is strongly influenced by the ganglioside composition of the sample	Hildebrandt H	1996 Jun 10	GlyGen GlycoEpitope
8624728	Developmental changes of ganglioside expressions in postnatal rat cerebellar cortex	Kotani M	1995 Nov 27	GlyGen GlycoEpitope
7890749	Substrate specificity of beta 1,4-N-acetylgalactosaminyltransferase in vitro and in cDNA-transfected cells. GM2/GD2 synthase efficiently generates asialo-GM2 in certain cells	Yamashiro S	1995 Mar 17	PubChem
7782326	Molecular cloning of Sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase from mouse brain	Yoshida Y	1995 Jun 16	PubChem
7654064	Anti‐GM1 IgG antibodies and campylobacter bacteria in Guillain‐Barré syndrome: Evidence of molecular mimicry	Oomes PG	1995 Aug	PubChem
7654069	Acute axonal Guillain‐Barré syndrome with IgG antibodies against motor axons following parenteral gangliosides	Illa I	1995 Aug	PubChem
8027041	Differential expression of five sialyltransferase genes in human tissues.	Kitagawa H	1994 Jul 08	PubChem

PubAnnotation

Displaying entries **6 - 10** of 10 in total

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Title	Authors	Source	Publication Date	PubMed ID
Specific ganglioside changes in extraneural tissues of adult rats with hypothyroidism.	Saito M Sugiyama K	Biochim Biophys Acta	2000 Oct 18	11042389
Activation of human T lymphocytes by ganglioside-containing liposomes.	Yanagihara K Kato E Hitomi S Sunamoto J Wada H	Glycoconj J	1999 Jan	10580651
Gangliosides of Echinococcus multilocularis metacestodes.	Persat F Bouhours JF Petavy AF Mojon M	Biochim Biophys Acta	1994 Feb 22	8312377
Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ.	Merrill AH Jr van Echten G Wang E Sandhoff K	J Biol Chem	1993 Dec 25	8262970
Inhibitory effects of gangliosides on immune reactions of antibodies to neutral glycolipids in liposomes.	Shichijo S Alving CR	Biochim Biophys Acta	1986 Jun 13	3707956

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