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Vitronectin

Summary

GlyCosmos Lectin

GL_002853

Lectin Name Aliases

S-protein
Serum-spreading factor
V75
VN

Organism

Homo sapiens (human)

External Links

UniProt: P04004

Annotation

Keyword: 3D-structure Cell adhesion Direct protein sequencing Disulfide bond Glycoprotein Heparin-binding Phosphoprotein Proteomics identification Reference proteome Repeat Secreted Signal Sulfation

Gene Ontology (GO)

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	Reference
immune response	TAS	PMID
immune response	IEA	GO_REF
cell adhesion	TAS	PMID
cell-matrix adhesion	IDA	PMID PMID
cell-matrix adhesion	IGI	PMID

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

cell adhesion

cell-substrate adhesion [inference]

cell-matrix adhesion

smooth muscle cell-matrix adhesion

cell adhesion mediated by integrin

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

oligodendrocyte differentiation

endodermal cell differentiation

cell motility [inference]

cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein polymerization

extracellular structure organization [inference]

extracellular matrix organization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein polymerization

external encapsulating structure organization [inference]

extracellular matrix organization

developmental process [inference]

anatomical structure development [inference]

regeneration [inference]

animal organ regeneration [inference]

liver regeneration

animal organ development [inference]

animal organ regeneration [inference]

liver regeneration

gland development [inference]

liver development [inference]

liver regeneration

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

oligodendrocyte differentiation

endodermal cell differentiation

response to stimulus [inference]

immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

regulation of vascular endothelial growth factor receptor signaling pathway [inference]

positive regulation of vascular endothelial growth factor receptor signaling pathway

regulation of vascular endothelial growth factor signaling pathway [inference]

positive regulation of vascular endothelial growth factor signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of response to external stimulus [inference]

negative regulation of fibrinolysis

positive regulation of response to wounding [inference]

positive regulation of wound healing

positive regulation of blood coagulation [inference]

negative regulation of fibrinolysis

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation [inference]

negative regulation of fibrinolysis

positive regulation of hemostasis [inference]

positive regulation of blood coagulation [inference]

negative regulation of fibrinolysis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation

negative regulation of fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

regulation of vascular endothelial growth factor receptor signaling pathway [inference]

positive regulation of vascular endothelial growth factor receptor signaling pathway

regulation of vascular endothelial growth factor signaling pathway [inference]

positive regulation of vascular endothelial growth factor signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation [inference]

negative regulation of fibrinolysis

negative regulation of blood coagulation

regulation of fibrinolysis [inference]

negative regulation of fibrinolysis

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

positive regulation of response to external stimulus [inference]

negative regulation of fibrinolysis

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of response to external stimulus [inference]

negative regulation of fibrinolysis

positive regulation of response to wounding [inference]

positive regulation of wound healing

positive regulation of blood coagulation [inference]

negative regulation of fibrinolysis

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation [inference]

negative regulation of fibrinolysis

negative regulation of blood coagulation

regulation of fibrinolysis [inference]

negative regulation of fibrinolysis

negative regulation of wound healing [inference]

negative regulation of blood coagulation

positive regulation of wound healing

positive regulation of blood coagulation [inference]

negative regulation of fibrinolysis

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

positive regulation of response to wounding [inference]

positive regulation of wound healing

positive regulation of blood coagulation [inference]

negative regulation of fibrinolysis

regulation of cellular response to growth factor stimulus [inference]

regulation of vascular endothelial growth factor receptor signaling pathway [inference]

positive regulation of vascular endothelial growth factor receptor signaling pathway

regulation of cellular response to vascular endothelial growth factor stimulus [inference]

regulation of vascular endothelial growth factor signaling pathway [inference]

positive regulation of vascular endothelial growth factor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

regulation of vascular endothelial growth factor receptor signaling pathway [inference]

positive regulation of vascular endothelial growth factor receptor signaling pathway

regulation of vascular endothelial growth factor signaling pathway [inference]

positive regulation of vascular endothelial growth factor signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

regulation of cell adhesion

regulation of cell-substrate adhesion [inference]

positive regulation of cell-substrate adhesion

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation [inference]

negative regulation of fibrinolysis

negative regulation of blood coagulation

regulation of fibrinolysis [inference]

negative regulation of fibrinolysis

negative regulation of coagulation [inference]

negative regulation of blood coagulation

positive regulation of coagulation [inference]

positive regulation of blood coagulation [inference]

negative regulation of fibrinolysis

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation [inference]

negative regulation of fibrinolysis

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation [inference]

negative regulation of fibrinolysis

negative regulation of blood coagulation

regulation of fibrinolysis [inference]

negative regulation of fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation

positive regulation of hemostasis [inference]

positive regulation of blood coagulation [inference]

negative regulation of fibrinolysis

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation [inference]

negative regulation of fibrinolysis

negative regulation of blood coagulation

regulation of fibrinolysis [inference]

negative regulation of fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation

positive regulation of hemostasis [inference]

positive regulation of blood coagulation [inference]

negative regulation of fibrinolysis

Displaying entries **6 - 10** of 23 in total

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GO Term	Evidence Code	Reference
basement membrane	IEA	GO_REF
obsolete extracellular space
endoplasmic reticulum	IDA	GO_REF
Golgi lumen	IEA	GO_REF
symbiont-containing vacuole	EXP	PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

protein complex involved in cell adhesion [inference]

protein complex involved in cell-matrix adhesion

membrane protein complex [inference]

plasma membrane protein complex [inference]

alphav-beta3 integrin-vitronectin complex

peptidase inhibitor complex

cellular anatomical structure [inference]

external encapsulating structure [inference]

extracellular matrix

basement membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen [inference]

rough endoplasmic reticulum lumen

Golgi lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

blood microparticle

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
scavenger receptor activity	IEA	GO_REF
integrin binding	IDA	PMID
integrin binding	IBA	GO_REF
integrin binding	IPI	PMID
extracellular matrix structural constituent	RCA	PMID PMID PMID PMID PMID

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

identical protein binding

cell adhesion molecule binding [inference]

integrin binding

carbohydrate binding [inference]

polysaccharide binding

protein-containing complex binding [inference]

extracellular matrix binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

cargo receptor activity [inference]

scavenger receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Pathway

Displaying **all 7** entries
Pathway Name	Organism
Dengue virus activates/modulates innate and adaptive immune responses	Homo sapiens
Developmental Lineage of Pancreatic Ductal Cells	Homo sapiens
ECM proteoglycans	Homo sapiens
Integrin cell surface interactions	Homo sapiens
Molecules associated with elastic fibres	Homo sapiens
Regulation of Complement cascade	Homo sapiens
Syndecan interactions	Homo sapiens