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MIRAGE
protein C, inactivator of coagulation factors Va and VIIIa
Summary
- Gene Symbol
-
- PROC
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Calcium
- Cleavage on pair of basic residues
- Direct protein sequencing
- Disease variant
- Disulfide bond
- EGF-like domain
- Endoplasmic reticulum
- Gamma-carboxyglutamic acid
- Glycoprotein
- Golgi apparatus
- Hydroxylation
- Phosphoprotein
- Reference proteome
- Repeat
- Secreted
- Serine protease
- Signal
- Thrombophilia
- Zymogen
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of inflammatory response | ||
| negative regulation of coagulation | ||
| positive regulation of establishment of endothelial barrier |
GO Hierarchy
biological process
biological regulation [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular region | ||
| extracellular space | ||
| extracellular space | ||
| endoplasmic reticulum |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| serine-type endopeptidase activity | ||
| serine-type endopeptidase activity | ||
| serine-type endopeptidase activity | ||
| calcium ion binding | ||
| protein binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- serine protease
- Functional Category
-
- E: Amino acid transport and metabolism
- G: Carbohydrate transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
| Gene Ontology |
|---|
| hydrolase activity |
| proteolysis |
| serine-type endopeptidase activity |
| serine-type peptidase activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060903 | thrombosis | |
| DOID:0111902 | thrombophilia due to activated protein C resistance | |
| DOID:0111904 | autosomal recessive thrombophilia due to protein C deficiency | |
| DOID:0111909 | autosomal dominant thrombophilia due to protein C deficiency | |
| DOID:10591 | pre-eclampsia | |
| DOID:14115 | toxic shock syndrome | |
| DOID:2450 | central retinal vein occlusion | |
| DOID:2452 | thrombophilia | |
| DOID:2841 | asthma | |
| DOID:2988 | antiphospholipid syndrome |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 5624 | Xenbase:XB-GENE-973141 | ||
| 19123 | Xenbase:XB-GENE-973141 | MOUSE23485 | |
| 25268 | Xenbase:XB-GENE-973141 | RATNO13720 | |
| 281428 | BOVIN23858 | ||
| 393327 | DANRE28803 | ||
| 396954 | PIGXX08919 | ||
| 459593 | PANTR28606 | ||
| 476104 | CANLF06322 | ||
| 699077 | MACMU05799 | ||
| 100009223 | RABIT11583 |
