G00033MO

Summary
GlyTouCan ID
G00033MO
IUPAC Condensed
Gal(b1-3)[GlcNAc(b1-6)]GalNAc(a1-
Motifs
O-Glycan core 2
Subsumption Level
Fully-defined saccharide
Monoisotopic Mass
586.22
GlyConnect structure
GlyGen
ChEBI
PubChem Compound
PubChem Substance
3D Structures
GlycoShape
G00033MO
Displaying 1 entry
Archetype α β
G00034MO
G00033MO
G24720OO
Organisms
Taxonomic Hierarchy
GlycoGene Database (GGDB)
Displaying all 4 entries
Gene Symbol Donor Acceptor Reducing terminal(Acceptor) Product Reducing terminal(Product) Reference
B3GALNT2 UDP-GalNAc
G00033MO
Ser/Thr
G01707KB
Ser/Thr
GCNT1 UDP-GlcNAc
G00031MO
Ser/Thr (core 2)
G00033MO
Ser/Thr (core 2)
GCNT4 UDP-GlcNAc
G00031MO
Ser/Thr
G00033MO
Ser/Thr
GCNT3 UDP-GlcNAc
G00031MO
Ser/Thr
G00033MO
Ser/Thr
Displaying entries 1 - 5 of 22 in total
Gene Symbol Donor Acceptor Reducing terminal(Acceptor) Product Reducing terminal(Product) Reference
ST3GAL1 CMP-Neu5Ac
G00033MO
O-glycan Synthesis
G85608AG
O-glycan Synthesis
FUT2 GDP-Fuc
G00033MO
O-glycan Synthesis
G32426JY
O-glycan Synthesis
B4GALT4 UDP-Gal
G00033MO
pNP
G64973KT
pNP
B4GALT1 UDP-Gal
G00033MO
O-glycan Synthesis
G64973KT
O-glycan Synthesis
B4GALNT4 UDP-GalNAc
G00033MO
[alpha]-pNP
G52144RR
[alpha]-pNP
Displaying all 4 entries
Gene Symbol Donor Acceptor Reducing terminal(Acceptor) Reference
GAL3ST3 PAPS
G00033MO
octyl
B3GNT8 UDP-GlcNAc
G00033MO
core 2-pNp
B3GNT6 UDP-GlcNAc
G00033MO
[alpha]-pNP(core 2)
B3GNT7 UDP-GlcNAc
G00033MO
core 2-pNp
KEGG BRITE Database
Sequence Descriptors
GlycoCT
RES
1b:a-dgal-HEX-1:5
2s:n-acetyl
3b:b-dgal-HEX-1:5
4b:b-dglc-HEX-1:5
5s:n-acetyl
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:1o(6+1)4d
4:4d(2+1)5n
WURCS
WURCS=2.0/3,3,2/[a2112h-1a_1-5_2*NCC/3=O][a2112h-1b_1-5][a2122h-1b_1-5_2*NCC/3=O]/1-2-3/a3-b1_a6-c1
Literature
Displaying entries 21 - 30 of 42 in total
PubMed ID Title First Author Publication Date Source
10753916 Control of O-glycan branch formation. Molecular cloning and characterization of a novel thymus-associated core 2 beta1, 6-n-acetylglucosaminyltransferase Schwientek T 2000 Apr 14
  • PubChem
9915862 Molecular cloning and expression of a novel beta-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches Yeh JC 1999 Jan 29
  • PubChem
9988682 Control of O-glycan branch formation. Molecular cloning of human cDNA encoding a novel beta1,6-N-acetylglucosaminyltransferase forming core 2 and core 4 Schwientek T 1999 Feb 19
  • PubChem
10430883 Expression cloning of a human alpha1, 4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1-->4Galbeta-->R, a glycan specifically expressed in the gastric gland mucous cell-type mucin Nakayama J 1999 Aug 03
  • PubChem
9530955 Purification and characterization of the MUC1 mucin-type glycoprotein, epitectin, from human urine: structures of the major oligosaccharide alditols Bhavanandan VP 1998 Jan
  • GlyGen
  • PubChem
9857011 Synthesis of poly-N-acetyllactosamine in core 2 branched O-glycans. The requirement of novel beta-1,4-galactosyltransferase IV and beta-1,3-n-acetylglucosaminyltransferase Ujita M 1998 Dec 25
  • PubChem
1329093 Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen. Bierhuizen MF 1992 Oct 01
  • PubChem
1627559 The broad diversity of neutral and sialylated oligosaccharides derived from human salivary mucins Klein A 1992 Jul 7
  • GlyGen
1488058 Quantitation and structures of oligosaccharide chains in human trachea mucin glycoproteins Sangadala S 1992 Dec 02
  • GlyGen
3345749 Primary structure of neutral oligosaccharides derived from respiratory-mucus glycoproteins of a patient suffering from bronchiectasis, determined by combination of 500-MHz 1H-NMR spectroscopy and quantitative sugar analysis. 1. Structure of 16 oligosaccharides having the Gal beta(1----3)GalNAc-ol core (type 1) or the Gal beta(1----3)[GlcNAc beta(1----6)]GalNac-ol core (type 2) Klein A 1988 Feb 1
  • GlyGen
PubAnnotation
Displaying entries 1 - 5 of 10 in total
Title Authors Source Publication Date PubMed ID
In-Depth Profiling of O-Glycan Isomers in Human Cells Using C18 Nanoliquid Chromatography-Mass Spectrometry and Glycogenomics.
  • de Haan N
  • Narimatsu Y
  • Koed Møller Aasted M
  • Larsen ISB
  • Marinova IN
  • Dabelsteen S
  • Vakhrushev SY
  • Wandall HH
Anal Chem 2022 Mar 15 35245040
Sulfation of O-glycans on Mucin-type Proteins From Serous Ovarian Epithelial Tumors.
  • Thomsson KA
  • Vitiazeva V
  • Mateoiu C
  • Jin C
  • Liu J
  • Holgersson J
  • Weijdegård B
  • Sundfeldt K
  • Karlsson NG
Mol Cell Proteomics 2021 34555499
Deciphering Isomers with a Multiple Reaction Monitoring Method for the Complete Detectable O-Glycan Repertoire of the Candidate Therapeutic, Lubricin.
  • Flowers SA
  • Lane CS
  • Karlsson NG
Anal Chem 2019 Aug 6 31246420
The O-glycomap of lubricin, a novel mucin responsible for joint lubrication, identified by site-specific glycopeptide analysis.
  • Ali L
  • Flowers SA
  • Jin C
  • Bennet EP
  • Ekwall AK
  • Karlsson NG
Mol Cell Proteomics 2014 Dec 25187573
Almost all human gastric mucin O-glycans harbor blood group A, B or H antigens and are potential binding sites for Helicobacter pylori.
  • Rossez Y
  • Maes E
  • Lefebvre Darroman T
  • Gosset P
  • Ecobichon C
  • Joncquel Chevalier Curt M
  • Boneca IG
  • Michalski JC
  • Robbe-Masselot C
Glycobiology 2012 Sep 22522599

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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