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Spike glycoprotein

Summary

UniProt ID: P0DTC2
Gene Symbol: 2 S
Gene ID: 43740568
Organism: Severe acute respiratory syndrome coronavirus 2

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P0DTC2

PubChem

P0DTC2

The O-GlcNAc Database

P0DTC2

Re-Glyco

P0DTC2

Annotation

Keyword: 3D-structure Coiled coil Disulfide bond Fusion of virus membrane with host endosomal membrane Glycoprotein Host cell membrane Inhibition of host tetherin by virus Palmitate Reference proteome Signal Superantigen Transmembrane helix Viral attachment to host cell Viral envelope protein Virulence

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
virion attachment to host cell	IDA	PMID
virion attachment to host cell	IEA	GO_REF
fusion of virus membrane with host plasma membrane	IEA	GO_REF GO_REF
symbiont-mediated-mediated suppression of host tetherin activity	IEA	GO_REF
fusion of virus membrane with host endosome membrane	IEA	GO_REF GO_REF GO_REF

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

membrane fusion

fusion of virus membrane with host plasma membrane

viral process [inference]

membrane fusion involved in viral entry into host cell [inference]

biological process involved in interspecies interaction between organisms [inference]

modulation of process of another organism [inference]

symbiont-mediated perturbation of host process [inference]

symbiont-mediated perturbation of host defense response [inference]

symbiont-mediated-mediated suppression of host tetherin activity

symbiont-mediated perturbation of host immune response [inference]

symbiont-mediated perturbation of host innate immune response [inference]

symbiont-mediated suppression of host innate immune response

symbiont-mediated suppression of host immune response [inference]

symbiont-mediated suppression of host innate immune response

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

symbiont-mediated perturbation of host process [inference]

symbiont-mediated perturbation of host defense response [inference]

symbiont-mediated-mediated suppression of host tetherin activity

symbiont-mediated perturbation of host immune response [inference]

symbiont-mediated perturbation of host innate immune response [inference]

symbiont-mediated suppression of host innate immune response

symbiont-mediated suppression of host immune response [inference]

symbiont-mediated suppression of host innate immune response

adhesion of symbiont to host [inference]

adhesion of symbiont to host cell [inference]

virion attachment to host cell

receptor-mediated virion attachment to host cell

entry receptor-mediated virion attachment to host cell

symbiont entry into host [inference]

symbiont entry into host cell

endocytosis involved in viral entry into host cell

disruption of anatomical structure in another organism [inference]

symbiont-mediated disruption of host anatomical structure [inference]

symbiont-mediated disruption of host tissue

biological regulation [inference]

regulation of biological process [inference]

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of viral entry into host cell [inference]

positive regulation of viral entry into host cell

positive regulation by symbiont of entry into host [inference]

positive regulation of viral entry into host cell

positive regulation of biological process [inference]

positive regulation of viral process [inference]

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

positive regulation by symbiont of entry into host [inference]

positive regulation of viral entry into host cell

regulation of viral process [inference]

positive regulation of viral process [inference]

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

regulation of viral life cycle [inference]

regulation of viral entry into host cell [inference]

positive regulation of viral entry into host cell

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

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GO Term	Evidence Code	Reference
plasma membrane	TAS	Reactome Reactome Reactome Reactome Reactome
membrane	NAS	PMID
membrane	IDA	PMID
membrane	IEA	GO_REF GO_REF
viral envelope	NAS	PMID

GO Hierarchy

cellular component

virion component [inference]

viral membrane [inference]

viral envelope

virion membrane

cellular anatomical structure [inference]

membrane

plasma membrane

other organism part [inference]

host cellular component [inference]

host cell part [inference]

host cell membrane [inference]

host cell surface

host extracellular region

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
structural constituent of virion	IDA	PMID
identical protein binding	IPI	PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID
identical protein binding	IEA	GO_REF
host cell surface receptor binding	IDA	PMID PMID
host cell surface receptor binding	IEA	GO_REF

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of virion

binding [inference]

protein binding [inference]

identical protein binding

host cell surface binding [inference]

host cell surface receptor binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 56 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
17	N-linked (GlcNAc...) (complex) asparagine; by host	32366695 32518941 32979942 33077685 34004174 34782609	G04784US G20312EM G34852SB G46241DR G03596YS G86795LJ G24954UD G43638QT G22310AV G88374WZ G70375MX G80735OA G04672QB G61613II G02030ZB G12580WI G70087PV G95977AE G47737VJ G75983OB G69364JQ G89098OM G11911BT G20698EO G44211QA G72797UR G29651HS G70822IO G44953PJ G72667IM G16175ZV G80223IX G27126ED G08293MJ G24700EX G32340DX G84452RH G09528DL G10773YW G51640FO G56610MH G59540CB G82592ZH G85740DB G91636VS G19379ID G70418MS G62792OG G85228QD G44215PV G60923RB G06356OH G59626AS G14994KB G54600FO G80920RR G50757KG G55382TU G79568CQ G03382KH G68318VE G23863VK G83555HU G50073PQ G74430RZ G03574QJ G84820NF G27622TD G42575XX G62765YT G64527OM G11870QZ G72791KH G17735IE G74976AR G10256JP G88725PI G10486CT G50045TK G46687AB G59937CP G51287LK G61855PQ G28541PG G72735IY G15486FH G82119TF G92597CK G05724UK G31852PQ G33638WV G31936TA G49955PK G25987BV G49874UX G33609NS G39446WN G10339FR G29880MM G28997IA G39188ZX G41247ZX G64780OA G80966KZ G35029YA G23453IV G57776ZU G80475RE G94854LT G02815KT G06110VR G55220VL G73636FD G00406II G82364UA G11460AB G21726WW G64162JC G57317CE G60145BJ G66538GV G92050GC G20956ZV G74724QE G28681TP	UniProt GlyGen GlyConnect GlyConnect
61	N-linked (GlcNAc...) (hybrid) asparagine; by host	32155444 32363391 32366695 32518941 32979942 33064451 33077685 34004174 34782609	G83141DC G51572MS G99679NM G32926LW G03027LH G98596OT G73686WG G19517GM G11629QQ G85144OK G17650MH G54417MJ G03596YS G86795LJ G27947YN G36670VW G49739MP G05049IC G29501UT G63543FL G86752LQ G98611JV G95835XS G88374WZ G80735OA G40926MX G12580WI G37412TK G15038BD G06853GH G47737VJ G75983OB G00912UN G49906RN G78790NZ G69364JQ G33556XM G44211QA G29651HS G70822IO G44953PJ G88283PM G08293MJ G84452RH G43769HG G09528DL G56610MH G60033FS G85740DB G24835MQ G86182NS G09197ZW G46902YN G44215PV G60923RB G06356OH G59626AS G01650EU G23294PN G25079LO G70101JE G80920RR G55382TU G65184UU G79568CQ G03382KH G14463WK G68318VE G23863VK G83555HU G31916IQ G45504EY G03574QJ G84820NF G27622TD G37399XV G82463GQ G14260UH G83633GK G62765YT G64527OM G23432EQ G72790NZ G10256JP G88725PI G10486CT G23934NS G36191CD G50045TK G46687AB G59937CP G28541PG G72735IY G15486FH G82119TF G92597CK G72291OX G95865ZB G05724UK G14998VF G31852PQ G31936TA G49955PK G72787SB G81295CK G25987BV G49874UX G33609NS G39446WN G10339FR G29880MM G39188ZX G41247ZX G16407EV G35029YA G23453IV G57776ZU G80475RE G94854LT G02815KT G06110VR G00406II G82364UA G21726WW G57317CE G60145BJ G66538GV G92050GC G20956ZV G74724QE G14669DU G28681TP G31685JQ	UniProt GlyGen GlyConnect GlyConnect GlyConnect
63		33806155	G00031MO G29931IJ G57321FI	GlyGen GlyConnect GlyConnect
71		33806155	G00031MO G29931IJ G57321FI	GlyGen GlyConnect
73		33806155	G00031MO G29931IJ G57321FI	GlyGen GlyConnect
74	N-linked (GlcNAc...) (complex) asparagine; by host	32363391 32366695 32518941 32979942 33064451 33077685 34004174 34782609	G11115RO G66088HZ G50427EO G81128KB G32926LW G98596OT G19517GM G87015RU G11629QQ G85144OK G27947YN G36670VW G91473PK G24954UD G43638QT G86752LQ G98611JV G07799LX G51413EV G80735OA G22625SJ G69107AL G02030ZB G12580WI G37412TK G54612UD G47737VJ G75983OB G49906RN G78790NZ G69364JQ G89098OM G11911BT G20698EO G23505EP G99966GV G56284ZY G93526NJ G08110WX G33556XM G44211QA G72797UR G29651HS G70822IO G66760KM G83646BJ G44953PJ G51857BL G72667IM G25451PN G87051GH G08293MJ G84452RH G39619TI G43769HG G51640FO G56610MH G59540CB G82592ZH G85740DB G91636VS G19379ID G70418MS G24835MQ G62792OG G85228QD G44215PV G60923RB G06356OH G59626AS G14994KB G54600FO G01650EU G25079LO G48584BU G70101JE G80920RR G50757KG G55382TU G79568CQ G03382KH G68318VE G23863VK G83555HU G50073PQ G74430RZ G31916IQ G45504EY G14260UH G83633GK G62765YT G64527OM G72791KH G23432EQ G10256JP G86821NY G88725PI G10486CT G50045TK G46687AB G59937CP G51287LK G72735IY G55383ZG G72291OX G05724UK G31852PQ G33638WV G31936TA G49955PK G72787SB G81295CK G25987BV G49874UX G33609NS G10339FR G29880MM G39188ZX G16407EV G35029YA G23453IV G32995JP G80475RE G94854LT G02815KT G06110VR G00406II G82364UA G57317CE G60145BJ G92050GC G20956ZV G74724QE G14669DU G28681TP G31685JQ G63628AV	UniProt GlyGen GlyConnect GlyConnect GlyConnect
76		33806155	G00031MO G29931IJ G57321FI	GlyGen GlyConnect
94		33806155	G57321FI	GlyGen GlyConnect
95		33806155	G57321FI	GlyGen GlyConnect
114		33806155	G57321FI	GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 8** entries
Pathway Name	Organism
Attachment and Entry	Homo sapiens
Induction of Cell-Cell Fusion	Homo sapiens
Initial triggering of complement	Homo sapiens
Lectin pathway of complement activation	Homo sapiens
Maturation of spike protein	Homo sapiens
SARS-CoV-2 activates/modulates innate and adaptive immune responses	Homo sapiens
Translation of Structural Proteins	Homo sapiens
Virion Assembly and Release	Homo sapiens

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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International Collaboration

Acknowledgements