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G00052MO

Summary

GlyTouCan ID: G00052MO
IUPAC Condensed: Fuc(a1-2)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-
Motifs: Blood group H (type 2) Leb Lewis b Ley
Subsumption Level: Fully-defined saccharide
Monoisotopic Mass: 675.26

External Links

GlyGen

G00052MO

ChEBI

59045

PubChem Compound

45266908

PubChem Substance

252284113

CarbBank

329 642 2537 2538 2539 3605 4591 7421 7648 7781 7847 10751 14878 15221 16398 20238 22552 22553 22554 22555 23607 25838 27637 28542 28578 28581 28594 29591 34222 34676 34848 34944 34976 34984 35241 35825 35841 36884 36921 36945 37036 37265 38055 41388 42058 42330 42425 42873 42934 43451 43710 44221 44361 44371 44543 45121 45320 45465 45861 45867 45900 45905 46554 46775 47008 47073 47183 47330 47457 48385 48510 48721 49120 49149 49439 50275 50533

3D Structures

GLYCAM: LFucpa1-2DGalpb1-4[LFucpa1-3]DGlcpNAcb1-OH

GlycoShape

G00052MO

Displaying 1 entry
Archetype	α	β
G04690JX	G82236PZ	G00052MO

Organisms

Displaying entries **1 - 5** of 15 in total

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Organisms	Evidence
Oryctolagus cuniculus (rabbit)	GlyTouCan(glycome-db)
Chlorocebus aethiops (grivet)	GlyTouCan(glycome-db)
Felis catus (domestic cat)	GlyTouCan(glycome-db)
Helicobacter pylori	GlyTouCan(bcsdb) GlyTouCan(glycome-db)
Mus musculus (house mouse)	GlyTouCan(glycome-db)

Taxonomic Hierarchy

root

Viruses [inference]

Riboviria [inference]

Pararnavirae [inference]

Artverviricota [inference]

Revtraviricetes [inference]

Ortervirales [inference]

Retroviridae [inference]

Orthoretrovirinae [inference]

Lentivirus [inference]

Primate lentivirus group [inference]

unclassified Primate lentivirus group [inference]

Human immunodeficiency virus

Human immunodeficiency virus 1

cellular organisms [inference]

Bacteria (eubacteria) [inference]

Campylobacterota [inference]

Epsilonproteobacteria [inference]

Campylobacterales [inference]

Helicobacteraceae [inference]

Helicobacter [inference]

Helicobacter pylori

Eukaryota (eucaryotes) [inference]

Opisthokonta [inference]

Metazoa (metazoans) [inference]

Eumetazoa [inference]

Bilateria [inference]

Deuterostomia [inference]

Chordata (chordates) [inference]

Craniata [inference]

Vertebrata (vertebrates) [inference]

Gnathostomata (jawed vertebrates) [inference]

Teleostomi [inference]

Euteleostomi (bony vertebrates) [inference]

Sarcopterygii [inference]

Dipnotetrapodomorpha [inference]

Tetrapoda (tetrapods) [inference]

Amniota (amniotes) [inference]

Mammalia (mammals) [inference]

Theria [inference]

Eutheria (placentals) [inference]

Boreoeutheria [inference]

Laurasiatheria [inference]

Carnivora (carnivores) [inference]

Feliformia [inference]

Felidae (cat family) [inference]

Felinae [inference]

Felis [inference]

Felis catus (domestic cat)

Caniformia [inference]

Canidae (dog, coyote, wolf, fox) [inference]

Canis [inference]

Canis lupus (gray wolf) [inference]

Canis lupus familiaris (dog)

Artiodactyla (even-toed ungulates & whales) [inference]

Ruminantia [inference]

Pecora [inference]

Bovidae [inference]

Bovinae [inference]

Bos (cattle) [inference]

Bos taurus (domestic cattle)

Suina [inference]

Suidae (pigs) [inference]

Sus [inference]

Sus scrofa (pig)

Euarchontoglires [inference]

Glires (Rodents and rabbits) [inference]

Lagomorpha [inference]

Leporidae (rabbits and hares) [inference]

Oryctolagus [inference]

Oryctolagus cuniculus (rabbit)

Rodentia (rodent) [inference]

Myomorpha (mice and others) [inference]

Muroidea [inference]

Cricetidae [inference]

Cricetinae (hamsters) [inference]

Mesocricetus [inference]

Mesocricetus auratus (golden hamster)

Muridae [inference]

Murinae [inference]

Rattus

Mus (mice) [inference]

Mus [inference]

Mus musculus (house mouse)

Primates [inference]

Haplorrhini [inference]

Simiiformes [inference]

Catarrhini [inference]

Hominoidea (apes) [inference]

Hominidae (great apes) [inference]

Homininae [inference]

Homo [inference]

Homo sapiens (human)

Cercopithecoidea [inference]

Cercopithecidae (Old World monkeys) [inference]

Cercopithecinae [inference]

Chlorocebus [inference]

Chlorocebus aethiops (grivet)

GlycoGene Database (GGDB)

Displaying **all 2** entries
Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
FUT5	GDP-Fuc	G61459JW	R	G00052MO	R	16484342
FUT3	GDP-Fuc	G61459JW	R	G00052MO	R	7721776

Displaying **all 5** entries
Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
FUT5	GDP-Fuc	G61459JW	R	G00052MO	R	16484342
FUT5	GDP-Fuc	G61459JW	(CH2)8COOCH3	G00052MO	(CH2)8COOCH3	9079712
FUT3	GDP-Fuc	G61459JW	R	G00052MO	R	7721776
FUT3	GDP-Fuc	G61459JW	(CH2)8COOCH3	G00052MO	(CH2)8COOCH3	9079712
FUT6	GDP-Fuc	G61459JW	(CH2)8COOCH3	G00052MO	(CH2)8COOCH3	9079712

GlycoEpitope

Epitope ID: EP0018

Sequence Descriptors

GlycoCT

RES
1b:b-dglc-HEX-1:5
2s:n-acetyl
3b:a-lgal-HEX-1:5|6:d
4b:b-dgal-HEX-1:5
5b:a-lgal-HEX-1:5|6:d
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:1o(4+1)4d
4:4o(2+1)5d

WURCS

WURCS=2.0/3,4,3/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5][a2112h-1b_1-5]/1-2-3-2/a3-b1_a4-c1_c2-d1

Literature

Displaying entries **171 - 180** of **410** in total

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PubMed ID	Title	First Author	Publication Date	Source
16484342	Glycosyltransferases involved in type 1 chain and Lewis antigen biosynthesis exhibit glycan and core chain specificity	Holgersson J	2006 Feb 16	PubChem
16477004	An enzymatic ruler modulates Lewis antigen glycosylation of Helicobacter pylori LPS during persistent infection	Nilsson C	2006 Feb 13	PubChem
16963623	Inhibition of Xenograft Tumor Growth and Down-Regulation of ErbB Receptors by an Antibody Directed against Lewis Y Antigen	Farhan H	2006 Dec	PubChem
16595507	Enhanced efficacy of 90Y-radiolabeled anti-Lewis Y humanized monoclonal antibody hu3S193 and paclitaxel combined-modality radioimmunotherapy in a breast cancer model	Kelly MP	2006 Apr	PubChem
16140965	Improved Effector Functions of a Therapeutic Monoclonal Lewis Y-Specific Antibody by Glycoform Engineering	Schuster M	2005 Sep 01	PubChem
16266323	Three‐dimensional structures of carbohydrate determinants of Lewis system antigens: Implications for effective antibody targeting of cancer	Yuriev E	2005 Oct 21	PubChem
16203806	Enhanced efficacy of radioimmunotherapy with 90Y-CHX-A''-DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478	Lee FT	2005 Oct 01	PubChem
16248790	Carbohydrate Mimotopes in the Rational Design of Cancer Vaccines	Pashov A	2005 Oct 01	PubChem
16234847	Characterization of murine monoclonal antibodies against Helicobacter pylori lipopolysaccharide specific for Lex and Ley blood group determinants	Altman E	2005 Oct	BCSDB GlyGen
16155001	DC-SIGN Mediates Binding of Dendritic Cells to Authentic Pseudo-LewisY Glycolipids of Schistosoma mansoni Cercariae, the First Parasite-specific Ligand of DC-SIGN	Meyer S	2005 Nov 11	PubChem

PubAnnotation

Displaying entries **1 - 5** of 10 in total

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Title	Authors	Source	Publication Date	PubMed ID
Development of potent monoclonal antibody auristatin conjugates for cancer therapy.	Doronina SO Toki BE Torgov MY Mendelsohn BA Cerveny CG Chace DF DeBlanc RL Gearing RP Bovee TD Siegall CB Francisco JA Wahl AF Meyer DL Senter PD	Nat Biotechnol	2003 Jul	12778055
The expression of free oligosaccharides in human seminal plasma.	Chalabi S Easton RL Patankar MS Lattanzio FA Morrison JC Panico M Morris HR Dell A Clark GF	J Biol Chem	2002 Sep 6	12063266
Phenotypic variation in molecular mimicry between Helicobacter pylori lipopolysaccharides and human gastric epithelial cell surface glycoforms. Acid-induced phase variation in Lewis(x) and Lewis(y) expression by H. Pylori lipopolysaccharides.	Moran AP Knirel YA Senchenkova SN Widmalm G Hynes SO Jansson PE	J Biol Chem	2002 Feb 22	11741906
Pursuit of optimal carbohydrate-based anticancer vaccines: preparation of a multiantigenic unimolecular glycopeptide containing the Tn, MBr1, and Lewis(y) antigens.	Allen JR Harris CR Danishefsky SJ	J Am Chem Soc	2001 Mar 7	11456809
The fucosylated histo-blood group antigens H type 2 (blood group O, CD173) and Lewis Y (CD174) are expressed on CD34+ hematopoietic progenitors but absent on mature lymphocytes.	Cao Y Merling A Karsten U Schwartz-Albiez R	Glycobiology	2001 Aug	11479278

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

GlycoEpitope

Sequence Descriptors

International Collaboration

Acknowledgements