GlyCosmos Portal

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Organisms	Evidence
Ovis aries (sheep)	GlyTouCan(glycome-db)
Cricetulus griseus (Chinese hamster)	GlyTouCan(glycome-db)
Mus musculus (house mouse)	GlyConnectStructure GlyTouCan(glycome-db) GlycoEpitope
Bos taurus (domestic cattle)	GlyTouCan(glycome-db)
Escherichia coli	GlyTouCan(bcsdb)

Taxonomic Hierarchy

root

cellular organisms [inference]

Bacteria (eubacteria) [inference]

Pseudomonadota [inference]

Gammaproteobacteria [inference]

Enterobacterales [inference]

Enterobacteriaceae [inference]

Escherichia [inference]

Escherichia coli

Pseudomonadales [inference]

Pseudomonadaceae [inference]

Pseudomonas [inference]

Pseudomonas aeruginosa group [inference]

Pseudomonas aeruginosa

Eukaryota (eucaryotes) [inference]

Opisthokonta [inference]

Metazoa (metazoans) [inference]

Eumetazoa [inference]

Bilateria [inference]

Deuterostomia [inference]

Chordata (chordates) [inference]

Craniata [inference]

Vertebrata (vertebrates) [inference]

Gnathostomata (jawed vertebrates) [inference]

Teleostomi [inference]

Euteleostomi (bony vertebrates) [inference]

Sarcopterygii [inference]

Dipnotetrapodomorpha [inference]

Tetrapoda (tetrapods) [inference]

Amniota (amniotes) [inference]

Mammalia (mammals) [inference]

Theria [inference]

Eutheria (placentals) [inference]

Boreoeutheria [inference]

Euarchontoglires [inference]

Glires (Rodents and rabbits) [inference]

Rodentia (rodent) [inference]

Myomorpha (mice and others) [inference]

Muroidea [inference]

Muridae [inference]

Murinae [inference]

Mus (mice) [inference]

Mus [inference]

Mus musculus (house mouse)

Rattus [inference]

Rattus norvegicus (Norway rat)

Cricetidae [inference]

Cricetinae (hamsters) [inference]

Cricetulus [inference]

Cricetulus griseus (Chinese hamster)

Lagomorpha [inference]

Leporidae (rabbits and hares) [inference]

Oryctolagus [inference]

Oryctolagus cuniculus (rabbit)

Primates [inference]

Haplorrhini [inference]

Simiiformes [inference]

Catarrhini [inference]

Hominoidea (apes) [inference]

Hominidae (great apes) [inference]

Homininae [inference]

Homo [inference]

Homo sapiens (human)

Cercopithecoidea [inference]

Cercopithecidae (Old World monkeys) [inference]

Cercopithecinae [inference]

Chlorocebus [inference]

Chlorocebus aethiops (grivet)

Macaca (macaques) [inference]

Macaca mulatta (Rhesus monkey)

Laurasiatheria [inference]

Artiodactyla (even-toed ungulates & whales) [inference]

Ruminantia [inference]

Pecora [inference]

Bovidae [inference]

Bovinae [inference]

Bos (cattle) [inference]

Bos taurus (domestic cattle)

Caprinae [inference]

Ovis [inference]

Ovis aries (sheep)

Protostomia [inference]

Ecdysozoa [inference]

Panarthropoda [inference]

Arthropoda (arthropods) [inference]

Mandibulata [inference]

Pancrustacea [inference]

Crustacea (crustaceans) [inference]

Multicrustacea [inference]

Malacostraca [inference]

Eumalacostraca [inference]

Peracarida [inference]

Isopoda (pill bugs, wood lice and sea slaters) [inference]

Oniscidea (pillbugs) [inference]

Crinocheta [inference]

Armadillidae [inference]

Armadillo

Hexapoda (hexapods) [inference]

Insecta (insects) [inference]

Dicondylia [inference]

Pterygota (winged insects) [inference]

Neoptera [inference]

Endopterygota [inference]

Diptera (flies) [inference]

Brachycera [inference]

Muscomorpha [inference]

Eremoneura [inference]

Cyclorrhapha [inference]

Schizophora [inference]

Acalyptratae [inference]

Ephydroidea [inference]

Drosophilidae (pomace flies) [inference]

Drosophilinae [inference]

Drosophilini [inference]

Drosophila (fruit flies) [inference]

Sophophora [inference]

melanogaster group [inference]

melanogaster subgroup [inference]

Drosophila melanogaster (fruit fly)

Calyptratae [inference]

Oestroidea [inference]

Calliphoridae (blowflies) [inference]

Chrysomyinae [inference]

Phormini [inference]

Protophormia [inference]

Protophormia terraenovae (northern blowfly)

Nematoda (roundworms) [inference]

Chromadorea [inference]

Rhabditida [inference]

Rhabditina [inference]

Rhabditomorpha [inference]

Strongyloidea (lungworms) [inference]

Heligmosomidae [inference]

Nippostrongylus [inference]

Nippostrongylus brasiliensis

Rhabditoidea [inference]

Rhabditidae [inference]

Peloderinae [inference]

Caenorhabditis [inference]

Caenorhabditis elegans

Spirurina [inference]

Ascaridomorpha [inference]

Ascaridoidea [inference]

Toxocaridae [inference]

Toxocara [inference]

Toxocara canis (dog roundworm)

Spiralia [inference]

Lophotrochozoa [inference]

Platyhelminthes (flatworms) [inference]

Cestoda (tapeworms) [inference]

Eucestoda [inference]

Cyclophyllidea [inference]

Taeniidae [inference]

Echinococcus [inference]

Echinococcus granulosus group [inference]

Echinococcus granulosus

Taenia [inference]

Taenia hydatigena

Mesocestoididae [inference]

Mesocestoides [inference]

Trematoda [inference]

Digenea (flukes) [inference]

Plagiorchiida [inference]

Echinostomata [inference]

Echinostomatoidea [inference]

Fasciolidae [inference]

Fasciola [inference]

Fasciola hepatica (liver fluke)

Fungi [inference]

Dikarya [inference]

Ascomycota (ascomycetes) [inference]

saccharomyceta [inference]

Saccharomycotina (true yeasts) [inference]

Saccharomycetes [inference]

Saccharomycetales [inference]

Saccharomycetaceae [inference]

Saccharomyces [inference]

Saccharomyces cerevisiae (brewer's yeast)

Viruses [inference]

Riboviria [inference]

Pararnavirae [inference]

Artverviricota [inference]

Revtraviricetes [inference]

Ortervirales [inference]

Retroviridae [inference]

Orthoretrovirinae [inference]

Lentivirus [inference]

Primate lentivirus group [inference]

unclassified Primate lentivirus group [inference]

Human immunodeficiency virus

Human immunodeficiency virus 1

Orthornavirae [inference]

Pisuviricota [inference]

Pisoniviricetes [inference]

Nidovirales [inference]

Cornidovirineae [inference]

Coronaviridae [inference]

Orthocoronavirinae [inference]

Betacoronavirus [inference]

Sarbecovirus [inference]

Severe acute respiratory syndrome-related coronavirus [inference]

Severe acute respiratory syndrome coronavirus 2

GlycoGene Database (GGDB)

Displaying **all 4** entries
Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
C1GALT1	(not applicable)	G57321FI	Ser/Thr	G00031MO	Ser/Thr	11677243
ST6GALNAC1	CMP-Neu5Ac	G57321FI	Ser/Thr	G36123IU	Ser/Thr	10536037
ST6GALNAC1	CMP-Neu5Ac	G57321FI	O-glycan Synthesis	G36123IU	O-glycan Synthesis
B3GNT6	UDP-GlcNAc	G57321FI	[alpha]-pNP	G00035MO	[alpha]-pNP	11821425

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Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
C1GALT1	UDP-Gal	G57321FI	PSGL-1(EYEYLDYDFLPETEPPEM)	G00031MO	PSGL-1(EYEYLDYDFLPETEPPEM)	11677243
C1GALT1	UDP-Gal	G57321FI	O-glycan Synthesis	G00031MO	O-glycan Synthesis
B3GNT6	UDP-GlcNAc	G57321FI	O-glycan Synthesis	G00035MO	O-glycan Synthesis
B3GNT6	UDP-GlcNAc	G57321FI	[alpha]-pNP	G00035MO	[alpha]-pNP	11821425

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Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Reference
ST6GALNAC3	CMP-Neu5Ac	G57321FI	Ser/Thr	10536037
ST6GAL2	CMP-Neu5Ac	G57321FI	para-nitrophenol	12603328
ST6GALNAC2	CMP-Neu5Ac	G57321FI	benzyl	10742600 11062056
ST6GALNAC1	CMP-Neu5Ac	G57321FI	[alpha]-Bz	10536037
ST6GALNAC2	CMP-Neu5Ac	G57321FI	Ser/Thr	10536037

KEGG BRITE Database

KEGG ID

G00023

Enzyme

Reactions

Displaying **all 4** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05909	2.4.1.147	G57321FI	G00035MO
R05908	2.4.1.122	G57321FI	G00031MO
R05911	2.4.3.3	G57321FI	G36123IU
R05910	2.4.1.102 2.4.1.148	G57321FI	G00041MO

Core Protein

Displaying entries **1 - 10** of **819** in total

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UniProt ID	Protein Name	Reference	Source
A1A5C7	Solute carrier family 22 member 23	23584533	GlyGen
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	23584533	GlyGen
A6NH11	Glycolipid transfer protein domain-containing protein 2	23584533	GlyGen
A6NLU5	V-set and transmembrane domain-containing protein 2B	23584533	GlyGen
C9J069	Apical junction component 1 homolog	23584533 25813380	GlyGen
C9JH25	Proline-rich transmembrane protein 4	23584533	GlyGen
D9N008	Epiglycanin	1125949 115878	GlyConnect
O00151	PDZ and LIM domain protein 1	23584533	GlyGen
O00220	Tumor necrosis factor receptor superfamily member 10A	23584533 25813380	GlyGen
O00238	Bone morphogenetic protein receptor type-1B	23584533	GlyGen

GlycoEpitope

Epitope ID: EP0021

Pathway

Displaying entries **41 - 50** of 57 in total

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Pathway Name	Organism
Ficolins bind to repetitive carbohydrate structures on the target cell surface	Sus scrofa
Initial triggering of complement	Mus musculus
Initial triggering of complement	Gallus gallus
Initial triggering of complement	Xenopus tropicalis
Initial triggering of complement	Sus scrofa
Initial triggering of complement	Bos taurus
Initial triggering of complement	Canis familiaris
Initial triggering of complement	Rattus norvegicus
Initial triggering of complement	Homo sapiens
Lectin pathway of complement activation	Bos taurus

Sequence Descriptors

GlycoCT

RES
1b:a-dgal-HEX-1:5
2s:n-acetyl
LIN
1:1d(2+1)2n

WURCS

WURCS=2.0/1,1,0/[a2112h-1a_1-5_2*NCC/3=O]/1/

Literature

Displaying entries **51 - 60** of **2052** in total

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PubMed ID	Title	First Author	Publication Date	Source
37302553	O-GalNAc glycosylation determines intracellular trafficking of APP and Aβ production	Tachida Y	2023 Jul	PubChem
36760736	Design and synthesis of atorvastatin derivatives with enhanced water solubility, hepatoselectivity and stability	Maklakova SY	2023 Jan 25	PubChem
36636995	Multivalent Lactobionic Acid and N‐Acetylgalactosamine‐Conjugated Peptide Nucleic Acids for Efficient In Vivo Targeting of Hepatocytes	Kumar V	2023 Jan 20	PubChem
36677618	Expression and Characterisation of the First Snail-Derived UDP-Gal: Glycoprotein-N-acetylgalactosamine β-1,3-Galactosyltransferase (T-Synthase) from Biomphalaria glabrata	Zemkollari M	2023 Jan 05	PubChem
36757090	Metabolically Stable Anomeric Linkages Containing GalNAc–siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways	Kandasamy P	2023 Feb 09	PubChem
37975191	Gold nanoparticles decorated with monosaccharides and sulfated ligands as potential modulators of the lysosomal enzyme N-acetylgalactosamine-6-sulfatase (GALNS)	Buco F	2023 Dec 06	PubChem
37855126	Targeting Angiotensinogen With N -Acetylgalactosamine–Conjugated Small Interfering RNA to Reduce Blood Pressure	Ye D	2023 Dec	PubChem
37638886	Shorter Is Better: The α-(<scp>l</scp>)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs	Matsuda S	2023 Aug 28	PubChem
37616327	Molecular characterisation of Entamoeba histolytica UDP-glucose 4-epimerase, an enzyme able to provide building blocks for cyst wall formation	Nagode A	2023 Aug 24	PubChem
37003290	Fitusiran in haemophilia: a breakthrough drug with many unknowns	Peyvandi F	2023 Apr 29	PubChem

PubAnnotation

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Title	Authors	Source	Publication Date	PubMed ID
The Quest for Anticancer Vaccines: Deciphering the Fine-Epitope Specificity of Cancer-Related Monoclonal Antibodies by Combining Microarray Screening and Saturation Transfer Difference NMR.	Coelho H Matsushita T Artigas G Hinou H Cañada FJ Lo-Man R Leclerc C Cabrita EJ Jiménez-Barbero J Nishimura S Garcia-Martín F Marcelo F	J Am Chem Soc	2015 Oct 7	26366611
Single molecule study of heterotypic interactions between mucins possessing the Tn cancer antigen.	Haugstad KE Stokke BT Brewer CF Gerken TA Sletmoen M	Glycobiology	2015 May	25527429
Loss of Core 1-derived O-Glycans Decreases Breast Cancer Development in Mice.	Song K Herzog BH Fu J Sheng M Bergstrom K McDaniel JM Kondo Y McGee S Cai X Li P Chen H Xia L	J Biol Chem	2015 Aug 14	26124270
Identification of distinct glycoforms of IgA1 in plasma from patients with immunoglobulin A (IgA) nephropathy and healthy individuals.	Lehoux S Mi R Aryal RP Wang Y Schjoldager KT Clausen H van Die I Han Y Chapman AB Cummings RD Ju T	Mol Cell Proteomics	2014 Nov	25071157
Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL).	van Vliet SJ Vuist IM Lenos K Tefsen B Kalay H García-Vallejo JJ van Kooyk Y	J Biol Chem	2013 Sep 20	23918927

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

KEGG BRITE Database

GlycoEpitope

Sequence Descriptors

International Collaboration

Acknowledgements