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GlyTouCan
Glycan Structure Repository
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Glycomics MS Repository for glycan annotations from GlycoWorkbench
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Repository for lectin-assisted multimodality data
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G57321FI
Summary
- GlyTouCan ID
-
G57321FI
- IUPAC Condensed
- GalNAc(a1-
- Motifs
- Tn antigen
Organisms
| Organisms | Evidence |
|---|---|
| Ovis aries (sheep) | |
| Cricetulus griseus (Chinese hamster) | |
| Mus musculus (house mouse) | |
| Bos taurus (domestic cattle) | |
| Escherichia coli |
Taxonomic Hierarchy
root
cellular organisms [inference]
Eukaryota (eucaryotes) [inference]
Opisthokonta [inference]
Metazoa (metazoans) [inference]
GlycoGene Database (GGDB)
| Gene Symbol | Donor | Acceptor | Reducing terminal(Acceptor) | Product | Reducing terminal(Product) | Reference |
|---|---|---|---|---|---|---|
| C1GALT1 | (not applicable) |
G57321FI
|
Ser/Thr |
G00031MO
|
Ser/Thr | |
| ST6GALNAC1 | CMP-Neu5Ac |
G57321FI
|
Ser/Thr |
G36123IU
|
Ser/Thr | |
| ST6GALNAC1 | CMP-Neu5Ac |
G57321FI
|
O-glycan Synthesis |
G36123IU
|
O-glycan Synthesis | |
| B3GNT6 | UDP-GlcNAc |
G57321FI
|
[alpha]-pNP |
G00035MO
|
[alpha]-pNP |
| Gene Symbol | Donor | Acceptor | Reducing terminal(Acceptor) | Product | Reducing terminal(Product) | Reference |
|---|---|---|---|---|---|---|
| C1GALT1 | (not applicable) |
G57321FI
|
Ser/Thr |
G00031MO
|
Ser/Thr | |
| ST6GALNAC1 | CMP-Neu5Ac |
G57321FI
|
Ser/Thr |
G36123IU
|
Ser/Thr | |
| ST6GALNAC4 | CMP-Neu5Ac |
G57321FI
|
benzyl |
G36123IU
|
benzyl | |
| ST6GALNAC1 | CMP-Neu5Ac |
G57321FI
|
O-glycan Synthesis |
G36123IU
|
O-glycan Synthesis | |
| ST6GALNAC1 | CMP-Neu5Ac |
G57321FI
|
[Ala-Thr(*)-Ala]2-7 |
G36123IU
|
[Ala-Thr(*)-Ala]2-7 |
| Gene Symbol | Donor | Acceptor | Reducing terminal(Acceptor) | Reference |
|---|---|---|---|---|
| ST6GALNAC3 | CMP-Neu5Ac |
G57321FI
|
Ser/Thr | |
| ST6GAL2 | CMP-Neu5Ac |
G57321FI
|
para-nitrophenol | |
| ST6GALNAC2 | CMP-Neu5Ac |
G57321FI
|
benzyl | |
| ST6GALNAC1 | CMP-Neu5Ac |
G57321FI
|
[alpha]-Bz | |
| ST6GALNAC2 | CMP-Neu5Ac |
G57321FI
|
Ser/Thr |
KEGG BRITE Database
G00041MO
Core Protein
| UniProt ID | Protein Name | Reference | Source |
|---|---|---|---|
| Q9UKP4 | A disintegrin and metalloproteinase with thrombospondin motifs 7 | ||
| Q9UKU9 | Angiopoietin-related protein 2 | ||
| Q9ULB5 | Cadherin-7 | ||
| Q9ULC8 | Palmitoyltransferase ZDHHC8 | ||
| Q9ULF5 | Zinc transporter ZIP10 | ||
| Q9ULI3 | Protein HEG homolog 1 | ||
| Q9UMD9 | Collagen alpha-1(XVII) chain | ||
| Q9UMX5 | Neudesin | ||
| Q9UNA0 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | ||
| Q9UNE0 | Tumor necrosis factor receptor superfamily member EDAR |
GlycoEpitope
- Epitope ID
- EP0021
Pathway
| Pathway Name | Organism |
|---|---|
| E.coli O101 | Escherichia coli |
| E.coli O103 | Escherichia coli |
| E.coli O107 | Escherichia coli |
| E.coli O112ab | Escherichia coli |
| E.coli O112ac | Escherichia coli |
| E.coli O116 | Escherichia coli |
| E.coli O117 | Escherichia coli |
| E.coli O125ab | Escherichia coli |
| E.coli O127 | Escherichia coli |
| E.coli O128ab-H27 | Escherichia coli |
Sequence Descriptors
- GlycoCT
-
RES 1b:a-dgal-HEX-1:5 2s:n-acetyl LIN 1:1d(2+1)2n
- WURCS
- WURCS=2.0/1,1,0/[a2112h-1a_1-5_2*NCC/3=O]/1/
Literature
| PubMed ID | Title | First Author | Publication Date | Source |
|---|---|---|---|---|
| 34413198 | Minimal Physiologically Based Pharmacokinetic-Pharmacodynamic (mPBPK-PD) Model of N-Acetylgalactosamine–Conjugated Small Interfering RNA Disposition and Gene Silencing in Preclinical Species and Humans | Ayyar VS | 2021 Nov |
|
| 34474100 | GalNAc-siRNA conjugates: Prospective tools on the frontier of anti-viral therapeutics | Thangamani L | 2021 Nov |
|
| 34059811 | The current landscape of nucleic acid therapeutics | Kulkarni JA | 2021 May 31 |
|
| 34050373 | Severe homocysteinemia in two givosiran-treated porphyria patients: is free heme deficiency the culprit? | Petrides PE | 2021 May 29 |
|
| 33949602 | The effect of deoxyfluorination and O-acylation on the cytotoxicity of N-acetyl-<scp>d</scp>-gluco- and <scp>d</scp>-galactosamine hemiacetals | Hamala V | 2021 May 26 |
|
| 33950677 | Syntheses of Morpholine-Based Nucleotide Analogs for Hepatic siRNA Targeting and Stabilization | Hofmeister A | 2021 May 05 |
|
| 33942901 | SLN124, a GalNac‐siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron‐overload in a mouse model of β‐thalassaemia | Vadolas J | 2021 May 04 |
|
| 33861472 | Dysregulation of homocysteine homeostasis in acute intermittent porphyria patients receiving heme arginate or givosiran | To-Figueras J | 2021 May 04 |
|
| 33792132 | Sustained and targeted delivery of siRNA/DP7‐C nanoparticles from injectable thermosensitive hydrogel for hepatocellular carcinoma therapy | Zhao B | 2021 May 02 |
|
| 33806155 | Site-Specific O-Glycosylation Analysis of SARS-CoV-2 Spike Protein Produced in Insect and Human Cells | Bagdonaite I | 2021 Mar 25 |
|
PubAnnotation
| Title | Authors | Source | Publication Date | PubMed ID |
|---|---|---|---|---|
| Immunological response from an entirely carbohydrate antigen: design of synthetic vaccines based on Tn-PS A1 conjugates. |
|
J Am Chem Soc | 2009 Jul 22 | 19552408 |
| Two different glycosyltransferase defects that result in GalNAc alpha-O-peptide (Tn) expression. |
|
Glycobiology | 1994 Jun | 7949653 |
| Localization of O-glycan initiation, sphingomyelin synthesis, and glucosylceramide synthesis in Vero cells with respect to the endoplasmic reticulum-Golgi intermediate compartment. |
|
J Biol Chem | 1994 Feb 11 | 8307959 |
| Carbohydrate receptor-mediated gene transfer to human T leukaemic cells. |
|
Glycobiology | 1994 Aug | 7827404 |
