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decapping mRNA 1A

Summary

Gene Symbol

DCP1A

Aliases

HSA275986
SMAD4IP1
SMIF

Organism

Homo sapiens (human)

External Links

NCBI Gene

55802

HGNC

18714

KEGG Gene ID

PubChem

55802

Alliance of Genome Resources

HGNC:18714

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Hydrolase
Methylation
Nonsense-mediated mRNA decay
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NPI6	Smad4-interacting transcriptional co-activator Transcription factor SMIF

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	NAS
deadenylation-dependent decapping of nuclear-transcribed mRNA	NAS
deadenylation-dependent decapping of nuclear-transcribed mRNA	IBA
deadenylation-dependent decapping of nuclear-transcribed mRNA	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA methylguanosine-cap decapping

RNA decapping [inference]

mRNA methylguanosine-cap decapping

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA methylguanosine-cap decapping

RNA decapping [inference]

mRNA methylguanosine-cap decapping

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to cytoplasmic stress granule

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of biological quality [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
P-body	ISS
P-body	NAS
P-body	IBA
P-body	IEA
nucleus	EXP

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

P-body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

P-body

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

P-body

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
mRNA binding	IBA
protein binding	IPI
enzyme activator activity	IEA
kinesin binding	IEA
identical protein binding	IPI

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity

binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

mRNA binding

protein binding

cytoskeletal protein binding [inference]

kinesin binding

identical protein binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity

molecular function activator activity [inference]

enzyme activator activity

Gene Ontology information from NCBI Gene and UniProt.

Rhea

RHEA:67484

H₂O

H⁺ + N⁷-methyl-GDP

Enzyme

3.6.1.62

PMID

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Mus musculus	75901	MGI:1923151

ChIP-Atlas

Target Genes: Predicted target genes bound by given transcription factors. Target Genes
Potential target genes for DCP1A
Distance from TSS: ± 10 kb

Displaying entries **221 - 230** of **260** in total

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Gene Symbol	Description	Cellline (score)
ABHD13	abhydrolase domain containing 13	SH-EP(119) SH-EP(81)
GAL3ST3	galactose-3-O-sulfotransferase 3	HeLa(221)
PIGK	phosphatidylinositol glycan anchor biosynthesis class K	HeLa(320) SH-EP(82)
ST6GALNAC3	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	HeLa(212)
LYPLA2	lysophospholipase 2	HeLa(157)
PDE3B	phosphodiesterase 3B	HeLa(121) SH-EP(67)
ACYP2	acylphosphatase 2	HeLa(239) SH-EP(113)
SLC35B4	solute carrier family 35 member B4	HeLa(146) SH-EP(72)
ENTPD7	ectonucleoside triphosphate diphosphohydrolase 7	HeLa(160)
FUT8	fucosyltransferase 8	HeLa(137) SH-EP(158)

Colocalization: Predicted partner proteins colocalizing with given transcription factors. Colocalization
Colocalization analysis for DCP1A

Displaying **all 7** entries
Gene Symbol	Description	Cellline (score)
DCP1A	decapping mRNA 1A	HeLa(10) SH-EP(0) SH-EP(10)
HDAC9	histone deacetylase 9	SK-UT-1(0)
HDAC2	histone deacetylase 2	U-87_MG(0)
INSR	insulin receptor	SH-SY5Y(0)
SMCHD1	structural maintenance of chromosomes flexible hinge domain containing 1	SH-SY5Y(0) hTERT_RPE-1(0)
MORC2	MORC family CW-type zinc finger 2	HeLa(0)
HDAC4	histone deacetylase 4	SK-UT-1(0)

An integrative, comprehensive database to explore public Epigenetic dataset, including ChIP-Seq, DNase-Seq, ATAC-Seq, and Bisulfite-Seq data: ChIP-Atlas covers almost all public data archived in Sequence Read Archive of NCBI, EBI, and DDBJ with over 224,000 experiments.

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