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G57321FI

Summary

GlyTouCan ID: G57321FI
IUPAC Condensed: GalNAc(a1-
Motifs: Tn antigen

3D Structures

GLYCAM: DGalpNAca1-OH

GlycoShape

G57321FI

Organisms

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Organisms	Evidence
Ovis aries (sheep)	GlyTouCan(glycome-db)
Cricetulus griseus (Chinese hamster)	GlyTouCan(glycome-db)
Mus musculus (house mouse)	GlyConnectStructure GlyTouCan(glycome-db) GlycoEpitope
Bos taurus (domestic cattle)	GlyTouCan(glycome-db)
Escherichia coli	GlyTouCan(bcsdb)

Taxonomic Hierarchy

root

cellular organisms [inference]

Bacteria (eubacteria) [inference]

Pseudomonadota [inference]

Gammaproteobacteria [inference]

Enterobacterales [inference]

Enterobacteriaceae [inference]

Escherichia [inference]

Escherichia coli

Pseudomonadales [inference]

Pseudomonadaceae [inference]

Pseudomonas [inference]

Pseudomonas aeruginosa group [inference]

Pseudomonas aeruginosa

Eukaryota (eucaryotes) [inference]

Opisthokonta [inference]

Metazoa (metazoans) [inference]

Eumetazoa [inference]

Bilateria [inference]

Deuterostomia [inference]

Chordata (chordates) [inference]

Craniata [inference]

Vertebrata (vertebrates) [inference]

Gnathostomata (jawed vertebrates) [inference]

Teleostomi [inference]

Euteleostomi (bony vertebrates) [inference]

Sarcopterygii [inference]

Dipnotetrapodomorpha [inference]

Tetrapoda (tetrapods) [inference]

Amniota (amniotes) [inference]

Mammalia (mammals) [inference]

Theria [inference]

Eutheria (placentals) [inference]

Boreoeutheria [inference]

Euarchontoglires [inference]

Glires (Rodents and rabbits) [inference]

Rodentia (rodent) [inference]

Myomorpha (mice and others) [inference]

Muroidea [inference]

Muridae [inference]

Murinae [inference]

Mus (mice) [inference]

Mus [inference]

Mus musculus (house mouse)

Rattus [inference]

Rattus norvegicus (Norway rat)

Cricetidae [inference]

Cricetinae (hamsters) [inference]

Cricetulus [inference]

Cricetulus griseus (Chinese hamster)

Lagomorpha [inference]

Leporidae (rabbits and hares) [inference]

Oryctolagus [inference]

Oryctolagus cuniculus (rabbit)

Primates [inference]

Haplorrhini [inference]

Simiiformes [inference]

Catarrhini [inference]

Hominoidea (apes) [inference]

Hominidae (great apes) [inference]

Homininae [inference]

Homo [inference]

Homo sapiens (human)

Cercopithecoidea [inference]

Cercopithecidae (Old World monkeys) [inference]

Cercopithecinae [inference]

Chlorocebus [inference]

Chlorocebus aethiops (grivet)

Macaca (macaques) [inference]

Macaca mulatta (Rhesus monkey)

Laurasiatheria [inference]

Artiodactyla (even-toed ungulates & whales) [inference]

Ruminantia [inference]

Pecora [inference]

Bovidae [inference]

Bovinae [inference]

Bos (cattle) [inference]

Bos taurus (domestic cattle)

Caprinae [inference]

Ovis [inference]

Ovis aries (sheep)

Protostomia [inference]

Ecdysozoa [inference]

Panarthropoda [inference]

Arthropoda (arthropods) [inference]

Mandibulata [inference]

Pancrustacea [inference]

Crustacea (crustaceans) [inference]

Multicrustacea [inference]

Malacostraca [inference]

Eumalacostraca [inference]

Peracarida [inference]

Isopoda (pill bugs, wood lice and sea slaters) [inference]

Oniscidea (pillbugs) [inference]

Crinocheta [inference]

Armadillidae [inference]

Armadillo

Hexapoda (hexapods) [inference]

Insecta (insects) [inference]

Dicondylia [inference]

Pterygota (winged insects) [inference]

Neoptera [inference]

Endopterygota [inference]

Diptera (flies) [inference]

Brachycera [inference]

Muscomorpha [inference]

Eremoneura [inference]

Cyclorrhapha [inference]

Schizophora [inference]

Acalyptratae [inference]

Ephydroidea [inference]

Drosophilidae (pomace flies) [inference]

Drosophilinae [inference]

Drosophilini [inference]

Drosophila (fruit flies) [inference]

Sophophora [inference]

melanogaster group [inference]

melanogaster subgroup [inference]

Drosophila melanogaster (fruit fly)

Calyptratae [inference]

Oestroidea [inference]

Calliphoridae (blowflies) [inference]

Chrysomyinae [inference]

Phormini [inference]

Protophormia [inference]

Protophormia terraenovae (northern blowfly)

Nematoda (roundworms) [inference]

Chromadorea [inference]

Rhabditida [inference]

Rhabditina [inference]

Rhabditomorpha [inference]

Strongyloidea (lungworms) [inference]

Heligmosomidae [inference]

Nippostrongylus [inference]

Nippostrongylus brasiliensis

Rhabditoidea [inference]

Rhabditidae [inference]

Peloderinae [inference]

Caenorhabditis [inference]

Caenorhabditis elegans

Spirurina [inference]

Ascaridomorpha [inference]

Ascaridoidea [inference]

Toxocaridae [inference]

Toxocara [inference]

Toxocara canis (dog roundworm)

Spiralia [inference]

Lophotrochozoa [inference]

Platyhelminthes (flatworms) [inference]

Cestoda (tapeworms) [inference]

Eucestoda [inference]

Cyclophyllidea [inference]

Taeniidae [inference]

Echinococcus [inference]

Echinococcus granulosus group [inference]

Echinococcus granulosus

Taenia [inference]

Taenia hydatigena

Mesocestoididae [inference]

Mesocestoides [inference]

Trematoda [inference]

Digenea (flukes) [inference]

Plagiorchiida [inference]

Echinostomata [inference]

Echinostomatoidea [inference]

Fasciolidae [inference]

Fasciola [inference]

Fasciola hepatica (liver fluke)

Fungi [inference]

Dikarya [inference]

Ascomycota (ascomycetes) [inference]

saccharomyceta [inference]

Saccharomycotina (true yeasts) [inference]

Saccharomycetes [inference]

Saccharomycetales [inference]

Saccharomycetaceae [inference]

Saccharomyces [inference]

Saccharomyces cerevisiae (brewer's yeast)

Viruses [inference]

Riboviria [inference]

Pararnavirae [inference]

Artverviricota [inference]

Revtraviricetes [inference]

Ortervirales [inference]

Retroviridae [inference]

Orthoretrovirinae [inference]

Lentivirus [inference]

Primate lentivirus group [inference]

unclassified Primate lentivirus group [inference]

Human immunodeficiency virus

Human immunodeficiency virus 1

Orthornavirae [inference]

Pisuviricota [inference]

Pisoniviricetes [inference]

Nidovirales [inference]

Cornidovirineae [inference]

Coronaviridae [inference]

Orthocoronavirinae [inference]

Betacoronavirus [inference]

Sarbecovirus [inference]

Severe acute respiratory syndrome-related coronavirus [inference]

Severe acute respiratory syndrome coronavirus 2

GlycoGene Database (GGDB)

Displaying **all 4** entries
Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
C1GALT1	(not applicable)	G57321FI	Ser/Thr	G00031MO	Ser/Thr	11677243
ST6GALNAC1	CMP-Neu5Ac	G57321FI	Ser/Thr	G36123IU	Ser/Thr	10536037
ST6GALNAC1	CMP-Neu5Ac	G57321FI	O-glycan Synthesis	G36123IU	O-glycan Synthesis
B3GNT6	UDP-GlcNAc	G57321FI	[alpha]-pNP	G00035MO	[alpha]-pNP	11821425

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Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
C1GALT1	(not applicable)	G57321FI	Ser/Thr	G00031MO	Ser/Thr	11677243
ST6GALNAC1	CMP-Neu5Ac	G57321FI	Ser/Thr	G36123IU	Ser/Thr	10536037
ST6GALNAC4	CMP-Neu5Ac	G57321FI	benzyl	G36123IU	benzyl	11062056
ST6GALNAC1	CMP-Neu5Ac	G57321FI	O-glycan Synthesis	G36123IU	O-glycan Synthesis
ST6GALNAC1	CMP-Neu5Ac	G57321FI	[Ala-Thr(*)-Ala]2-7	G36123IU	[Ala-Thr(*)-Ala]2-7	10536037

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Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Reference
ST6GALNAC3	CMP-Neu5Ac	G57321FI	Ser/Thr	10536037
ST6GAL2	CMP-Neu5Ac	G57321FI	para-nitrophenol	12603328
ST6GALNAC2	CMP-Neu5Ac	G57321FI	benzyl	10742600 11062056
ST6GALNAC1	CMP-Neu5Ac	G57321FI	[alpha]-Bz	10536037
ST6GALNAC2	CMP-Neu5Ac	G57321FI	Ser/Thr	10536037

KEGG BRITE Database

KEGG ID

G00023

Enzyme

Reactions

Displaying **all 4** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05908	2.4.1.122	G57321FI	G00031MO
R05910	2.4.1.102 2.4.1.148	G57321FI	G00041MO
R05911	2.4.3.3	G57321FI	G36123IU
R05909	2.4.1.147	G57321FI	G00035MO

Core Protein

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UniProt ID	Protein Name	Reference	Source
Q9Y624	Junctional adhesion molecule A	23584533 25813380	GlyGen
Q9Y625	Glypican-6	23584533	GlyGen
Q9Y653	Adhesion G-protein coupled receptor G1	23584533 25813380	GlyGen
Q9Y662	Heparan sulfate glucosamine 3-O-sulfotransferase 3B1	23584533	GlyGen
Q9Y6C2	EMILIN-1	23584533	GlyGen
Q9Y6I9	Testis-expressed protein 264	25813380	GlyGen
Q9Y6L7	Tolloid-like protein 2	23584533	GlyGen
Q9Y6M5	Proton-coupled zinc antiporter SLC30A1	23584533	GlyGen
Q9Y6N7	Roundabout homolog 1	23584533	GlyGen

GlycoEpitope

Epitope ID: EP0021

Pathway

Displaying entries **21 - 30** of 57 in total

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Pathway Name	Organism
E.coli O5ab	Escherichia coli
E.coli O5ac	Escherichia coli
E.coli O61	Escherichia coli
E.coli O65	Escherichia coli
E.coli O6H10K54	Escherichia coli
E.coli O6H16K15	Escherichia coli
E.coli O70	Escherichia coli
E.coli O71	Escherichia coli
E.coli O73ab	Escherichia coli
E.coli O86	Escherichia coli

Sequence Descriptors

GlycoCT

RES
1b:a-dgal-HEX-1:5
2s:n-acetyl
LIN
1:1d(2+1)2n

WURCS

WURCS=2.0/1,1,0/[a2112h-1a_1-5_2*NCC/3=O]/1/

Literature

Displaying entries **481 - 490** of **2052** in total

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PubMed ID	Title	First Author	Publication Date	Source
22549772	Glycosylation of α-dystroglycan: O-mannosylation influences the subsequent addition of GalNAc by UDP-GalNAc polypeptide N-acetylgalactosaminyltransferases	Tran DT	2012 Jun 15	PubChem
22595178	Investigation of the nucleotide triphosphate substrate specificity of Homo sapiens UDP-N-acetylgalactosamine pyrophosphorylase (AGX1)	Xue M	2012 Jun 15	PubChem
22678432	Determination of site-specific glycan heterogeneity on glycoproteins	Kolarich D	2012 Jun 07	GlyGen PubChem
22505337	Exposure to Host Ligands Correlates with Colocalization of Gal/GalNAc Lectin Subunits in Lipid Rafts and Phosphatidylinositol (4,5)-Bisphosphate Signaling in Entamoeba histolytica	Goldston AM	2012 Jun	PubChem
22387147	Raman microspectroscopy as a non-invasive tool to assess the vitrification-induced changes of ovine oocyte zona pellucida	Bogliolo L	2012 Jun	PubChem
22797904	Fluorescein-5-thiosemicarbazide as a probe for directly imaging of mucin-type O-linked glycoprotein within living cells	Zhang Y	2012 Jul 15	PubChem
22791304	Toward Stable Genetic Engineering of Human O-Glycosylation in Plants	Yang Z	2012 Jul 12	PubChem
22781125	O-Mannose and O–N-acetyl galactosamine glycosylation of mammalian α-dystroglycan is conserved in a region-specific manner	Gomez Toledo A	2012 Jul 09	PubChem
22762189	Purification and Characterization of a Novel Anti-Proliferative Lectin from Morus alba L. Leaves	Deepa M	2012 Jul 01	PubChem
22308371	The human circadian metabolome	Dallmann R	2012 Jan 31	PubChem

PubAnnotation

Displaying entries **1 - 5** of 9 in total

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Title	Authors	Source	Publication Date	PubMed ID
A newly generated functional antibody identifies Tn antigen as a novel determinant in the cancer cell-lymphatic endothelium interaction.	Danussi C Coslovi A Campa C Mucignat MT Spessotto P Uggeri F Paoletti S Colombatti A	Glycobiology	2009 Oct	19528665
Enzymatic large-scale synthesis of MUC6-Tn glycoconjugates for antitumor vaccination.	Freire T Lo-Man R Piller F Piller V Leclerc C Bay S	Glycobiology	2006 May	16449349
Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen.	Zhang Y Iwasaki H Wang H Kudo T Kalka TB Hennet T Kubota T Cheng L Inaba N Gotoh M Togayachi A Guo J Hisatomi H Nakajima K Nishihara S Nakamura M Marth JD Narimatsu H	J Biol Chem	2003 Jan 3	12407114
Purification, characterization, and cDNA cloning of alpha-N-acetylgalactosamine-specific lectin from starfish, Asterina pectinifera.	Kakiuchi M Okino N Sueyoshi N Ichinose S Omori A Kawabata S Yamaguchi K Ito M	Glycobiology	2002 Feb	11886841
Pursuit of optimal carbohydrate-based anticancer vaccines: preparation of a multiantigenic unimolecular glycopeptide containing the Tn, MBr1, and Lewis(y) antigens.	Allen JR Harris CR Danishefsky SJ	J Am Chem Soc	2001 Mar 7	11456809

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

KEGG BRITE Database

GlycoEpitope

Sequence Descriptors

International Collaboration

Acknowledgements