G57321FI
| Organisms | Evidence | 
|---|---|
| Ovis aries (sheep) | |
| Cricetulus griseus (Chinese hamster) | |
| Mus musculus (house mouse) | |
| Bos taurus (domestic cattle) | |
| Escherichia coli | 
| Gene Symbol | Donor | Acceptor | Reducing terminal(Acceptor) | Product | Reducing terminal(Product) | Reference | 
|---|---|---|---|---|---|---|
| C1GALT1 | (not applicable) | 
                          
                             | 
                    Ser/Thr | 
                          
                             | 
                    Ser/Thr | |
| ST6GALNAC1 | CMP-Neu5Ac | 
                          
                             | 
                    Ser/Thr | 
                          
                             | 
                    Ser/Thr | |
| ST6GALNAC1 | CMP-Neu5Ac | 
                          
                             | 
                    O-glycan Synthesis | 
                          
                             | 
                    O-glycan Synthesis | |
| B3GNT6 | UDP-GlcNAc | 
                          
                             | 
                    [alpha]-pNP | 
                          
                             | 
                    [alpha]-pNP | 
| Gene Symbol | Donor | Acceptor | Reducing terminal(Acceptor) | Product | Reducing terminal(Product) | Reference | 
|---|---|---|---|---|---|---|
| C1GALT1 | (not applicable) | 
                          
                             | 
                    Ser/Thr | 
                          
                             | 
                    Ser/Thr | |
| ST6GALNAC1 | CMP-Neu5Ac | 
                          
                             | 
                    Ser/Thr | 
                          
                             | 
                    Ser/Thr | |
| ST6GALNAC4 | CMP-Neu5Ac | 
                          
                             | 
                    benzyl | 
                          
                             | 
                    benzyl | |
| ST6GALNAC1 | CMP-Neu5Ac | 
                          
                             | 
                    O-glycan Synthesis | 
                          
                             | 
                    O-glycan Synthesis | |
| ST6GALNAC1 | CMP-Neu5Ac | 
                          
                             | 
                    [Ala-Thr(*)-Ala]2-7 | 
                          
                             | 
                    [Ala-Thr(*)-Ala]2-7 | 
| Gene Symbol | Donor | Acceptor | Reducing terminal(Acceptor) | Reference | 
|---|---|---|---|---|
| ST6GALNAC3 | CMP-Neu5Ac | 
                          
                             | 
                    Ser/Thr | |
| ST6GAL2 | CMP-Neu5Ac | 
                          
                             | 
                    para-nitrophenol | |
| ST6GALNAC2 | CMP-Neu5Ac | 
                          
                             | 
                    benzyl | |
| ST6GALNAC1 | CMP-Neu5Ac | 
                          
                             | 
                    [alpha]-Bz | |
| ST6GALNAC2 | CMP-Neu5Ac | 
                          
                             | 
                    Ser/Thr | 
| UniProt ID | Protein Name | Reference | Source | 
|---|---|---|---|
| Q9Y624 | Junctional adhesion molecule A | ||
| Q9Y625 | Glypican-6 | ||
| Q9Y653 | Adhesion G-protein coupled receptor G1 | ||
| Q9Y662 | Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 | ||
| Q9Y6C2 | EMILIN-1 | ||
| Q9Y6I9 | Testis-expressed protein 264 | ||
| Q9Y6L7 | Tolloid-like protein 2 | ||
| Q9Y6M5 | Proton-coupled zinc antiporter SLC30A1 | ||
| Q9Y6N7 | Roundabout homolog 1 | 
| Pathway Name | Organism | 
|---|---|
| Lectin pathway of complement activation | Bos taurus | 
| Lectin pathway of complement activation | Rattus norvegicus | 
| Lectin pathway of complement activation | Mus musculus | 
| Lectin pathway of complement activation | Homo sapiens | 
| Lectin pathway of complement activation | Xenopus tropicalis | 
| Lectin pathway of complement activation | Gallus gallus | 
| Lectin pathway of complement activation | Canis familiaris | 
RES 1b:a-dgal-HEX-1:5 2s:n-acetyl LIN 1:1d(2+1)2n
| PubMed ID | Title | First Author | Publication Date | Source | 
|---|---|---|---|---|
| 38348876 | A combinatorial approach for achieving CNS-selective RNAi | Ferguson CM | 2024 Feb 13 | 
                  
  | 
          
| 38227794 | Safety and Tolerability of GalNAc3-Conjugated Antisense Drugs Compared to the Same-Sequence 2′-O-Methoxyethyl-Modified Antisense Drugs: Results from an Integrated Assessment of Phase 1 Clinical Trial Data | Baker BF | 2024 Feb 01 | 
                  
  | 
          
| 39177802 | Givosiran for the Treatment of Pediatric Acute Intermittent Porphyria | Bujold KE | 2024 Aug 22 | 
                  
  | 
          
| 39126245 | O-GlcNAcylation determines the function of the key O-GalNAc glycosyltransferase C1GalT1 in bladder cancer | Jiang Y | 2024 Aug 01 | 
                  
  | 
          
| 38667801 | Chemical Synthesis of Fucosylated Chondroitin Sulfate Tetrasaccharide with Fucosyl Branch at the 6-OH of GalNAc Residue | Lv C | 2024 Apr 19 | 
                  
  | 
          
| 38479165 | Research progress on asialoglycoprotein receptor-targeted radiotracers designed for hepatic nuclear medicine imaging | Hua Y | 2024 Apr 05 | 
                  
  | 
          
| 38570436 | Cross-Reactive Polyclonal Antibodies Raised Against GalNAc-Conjugated siRNA Recognize Mostly the GalNAc Moiety | Ballman KK | 2024 Apr 03 | 
                  
  | 
          
| 38708485 | Recovery of chronic motor neuropathy due to acute intermittent porphyria after givosiran treatment in a young boy: a case report | Mazzoli M | 2024 Apr | 
                  
  | 
          
| 38401583 | Deficiency of polypeptide N-acetylgalactosamine transferase 9 contributes to a risk for Parkinson's disease via mitochondrial dysfunctions | Peng Y | 2024 Apr | 
                  
  | 
          
| 38995536 | Integrating HexNAcQuest with Glycoproteomics Data Analysis Software to Distinguish HexNAc Isomers on Peptides | Hou C | 2024 | 
                  
  | 
          
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Supported by JST NBDC Grant Number JPMJND2204
Partly supported by NIH Common Fund Grant #1U01GM125267-01
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Last updated: August 4, 2025