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Immunoglobulin heavy constant epsilon

Summary

UniProt ID: P01854
Gene Symbol: IGHE
Gene ID
Organism: Homo sapiens (human)

External Links

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P01854

PubChem

P01854

Re-Glyco

P01854

Annotation

Keyword: 3D-structure Alternative splicing Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Immunoglobulin Immunoglobulin domain Inflammatory response Proteomics identification Reference proteome Repeat Secreted Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	Reference
antibody-dependent cellular cytotoxicity	IDA	PMID
adaptive immune response	NAS	PMID
B cell antigen processing and presentation	IDA	PMID
inflammatory response
immune response	NAS	PMID

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

leukocyte mediated cytotoxicity [inference]

antibody-dependent cellular cytotoxicity

myeloid leukocyte mediated immunity [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

lymphocyte mediated immunity [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

type I hypersensitivity

complement activation [inference]

complement activation, classical pathway

leukocyte degranulation [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

complement activation [inference]

complement activation, classical pathway

immune response

adaptive immune response

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

type I hypersensitivity

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus [inference]

hypersensitivity [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

type I hypersensitivity

humoral immune response [inference]

complement activation [inference]

complement activation, classical pathway

antimicrobial humoral response [inference]

antibacterial humoral response

type 2 immune response

antigen processing and presentation [inference]

B cell antigen processing and presentation

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation

lymphocyte activation [inference]

B cell activation

B cell proliferation

lymphocyte proliferation [inference]

B cell proliferation

immunological memory process [inference]

adaptive immune memory response

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation

lymphocyte activation [inference]

B cell activation

B cell proliferation

lymphocyte proliferation [inference]

B cell proliferation

cell killing [inference]

leukocyte mediated cytotoxicity [inference]

antibody-dependent cellular cytotoxicity

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

cell population proliferation [inference]

leukocyte proliferation [inference]

mononuclear cell proliferation [inference]

lymphocyte proliferation [inference]

B cell proliferation

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

Fc receptor-mediated immune complex endocytosis

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

mononuclear cell differentiation

macrophage differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation

lymphocyte activation [inference]

B cell activation

B cell proliferation

lymphocyte proliferation [inference]

B cell proliferation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

mononuclear cell differentiation

macrophage differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus [inference]

hypersensitivity [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

type I hypersensitivity

acute inflammatory response [inference]

acute inflammatory response to antigenic stimulus [inference]

hypersensitivity [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

type I hypersensitivity

defense response to bacterium [inference]

antibacterial humoral response

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

immune response

adaptive immune response

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

type I hypersensitivity

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus [inference]

hypersensitivity [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

type I hypersensitivity

humoral immune response [inference]

complement activation [inference]

complement activation, classical pathway

antimicrobial humoral response [inference]

antibacterial humoral response

type 2 immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

Fc receptor-mediated immune complex endocytosis

secretion [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

Fc receptor-mediated immune complex endocytosis

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

establishment of localization in cell [inference]

leukocyte degranulation [inference]

establishment of organelle localization [inference]

mast cell degranulation

organelle localization [inference]

establishment of organelle localization [inference]

mast cell degranulation

vacuolar localization [inference]

lysosome localization [inference]

mast cell degranulation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

complement activation [inference]

complement activation, classical pathway

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

complement activation [inference]

complement activation, classical pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

complement activation [inference]

complement activation, classical pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

complement activation [inference]

complement activation, classical pathway

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

complement activation [inference]

complement activation, classical pathway

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

complement activation [inference]

complement activation, classical pathway

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
extracellular region	EXP	PMID
extracellular region	TAS	Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome
extracellular region	IDA	PMID PMID PMID
extracellular region	IEA	GO_REF GO_REF
obsolete extracellular space

GO Hierarchy

cellular component

protein-containing complex [inference]

immunoglobulin complex [inference]

B cell receptor complex [inference]

IgE B cell receptor complex

immunoglobulin complex, circulating

IgE immunoglobulin complex

IgE B cell receptor complex

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

B cell receptor complex [inference]

IgE B cell receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

B cell receptor complex [inference]

IgE B cell receptor complex

extracellular protein-containing complex [inference]

immunoglobulin complex, circulating

cellular anatomical structure [inference]

extracellular region

membrane [inference]

plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	Reference
antigen binding	NAS	PMID
antigen binding	IBA	GO_REF
immunoglobulin receptor binding	IDA	PMID PMID
immunoglobulin receptor binding	IBA	GO_REF
immunoglobulin receptor binding	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

antigen binding

protein binding [inference]

signaling receptor binding [inference]

immunoglobulin receptor binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

ASTQSPSVFPLTRCCKNIPSNATSVTLGCLATGYFPEPVMVTWDTGSLNGTTMTLPATTLTLSGHYATISLLTVSGAWAKQMFTCRVAHTPSSTDWVDNKTFSVCSRDFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGYTPGTINITWLEDGQVMDVDLSTASTTQEGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCADSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPGLAGGSAQSQRAPDRVLCHSGQQQGLPRAAGGSVPHPRCHCGAGRADWPGPPELDVCVEEAEGEAPWTWTGLCIFAALFLLSVSYSAAITLLMVQRFLSATRQGRPQTSLDYTNVLQPHA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 8** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
21	N-linked (GlcNAc...) asparagine	24308486 25824821	G64394MX G57888GL G97268YK G34617SM G68209WQ G11629QQ G79939YZ G31596VW G65219TP G91473PK G25379SA G27102CT G90093AU G24954UD G32246SI G81263BG G08146BT G22310AV G70375MX G02030ZB G05850WN G89098OM G65186XA G72797UR G45495MK G84452RH G61627IG G91636VS G43157UW G79568CQ G03382KH G23863VK G57818FI G10256JP G92129PT G46687AB	UniProt GlyGen GlyConnect
49	N-linked (GlcNAc...) asparagine	24308486 25824821	G67506FN G64394MX G83295QG G97268YK G34617SM G68209WQ G11629QQ G79939YZ G45883VE G65219TP G91473PK G25379SA G27102CT G90093AU G32246SI G81263BG G08146BT G22310AV G70375MX G02030ZB G05850WN G65186XA G72797UR G45495MK G84452RH G61627IG G91636VS G43157UW G79568CQ G23863VK G57818FI G22140GZ G50045TK	UniProt GlyGen GlyConnect
99	N-linked (GlcNAc...) asparagine	24308486 25824821 26687240 8645991	G39595FH G64394MX G83295QG G34617SM G68209WQ G11629QQ G79939YZ G45883VE G65219TP G91473PK G27102CT G90093AU G32246SI G81263BG G08146BT G22310AV G02030ZB G05850WN G65186XA G72797UR G45495MK G84452RH G61627IG G91636VS G43157UW G79568CQ G03382KH G23863VK G57818FI G22140GZ G50045TK	UniProt GlyGen GlyConnect
146	N-linked (GlcNAc...) asparagine	24308486 25824821	G64394MX G97268YK G34617SM G68209WQ G11629QQ G79939YZ G45883VE G31596VW G65219TP G91473PK G25379SA G27102CT G90093AU G32246SI G81263BG G08146BT G22310AV G70375MX G02030ZB G05850WN G89098OM G45495MK G84452RH G61627IG G91636VS G43157UW G79568CQ G03382KH G23863VK G57818FI G22140GZ G50045TK	UniProt GlyGen GlyConnect
252	N-linked (GlcNAc...) asparagine	24308486 25824821 26687240	G11629QQ G79939YZ G65219TP G91473PK G32246SI G81263BG G08146BT G22310AV G02030ZB G05850WN G72667IM G45495MK G84452RH G82592ZH G61627IG G91636VS G70418MS G50757KG G43157UW G79568CQ G03382KH G23863VK G57818FI G10256JP G92129PT G46687AB	UniProt GlyGen GlyConnect
264	N-linked (GlcNAc...) asparagine	25824821 26687240	G84452RH G10773YW G61627IG G91636VS G34730YF G03382KH G23863VK G57818FI G10256JP G92129PT G46687AB G82119TF G06110VR G55220VL	UniProt GlyGen GlyConnect
275	N-linked (GlcNAc...) asparagine	10917520 23090970 24308486 25824821 26687240 29671580	G39617JJ G70101JE G64527OM G66676MI G98940JV G05724UK G48626HI G82020ZR G33609NS G89319AW G26624YG G39188ZX G02815KT G06110VR G54059XR G55220VL G02402FF G66538GV G14669DU G22768VO G03717EM G63628AV	UniProt GlyGen GlyConnect
unknown		15557177 24698316 4361830 4361831	G66088HZ G11629QQ G52527GH G14127XU G65219TP G91473PK G81263BG G26403SG G50779LX G08146BT G22310AV G56749GV G59536GA G02030ZB G42358LZ G48414YA G66760KM G67942CH G72667IM G11041DA G12708JQ G30460NZ G53752TA G81413UE G84452RH G20425TQ G29857RC G79809MM G25520XG G61627IG G91636VS G24835MQ G04909DG G06356OH G70101JE G43157UW G79568CQ G03382KH G71013KY G85767HW G23863VK G57818FI G78059CC G64527OM G66676MI G11535IB G23432EQ G10256JP G30159WR G22140GZ G36191CD G50045TK G27919IH G46687AB G58667NI G61937QU G82119TF G82942ZJ G05724UK G82020ZR G10219AA G31936TA G59471TH G75798PH G81295CK G49874UX G56903ZB G80858MF G33609NS G12398HZ G29880MM G68698AP G10471FG G17433EW G39188ZX G80966KZ G23453IV G27993JQ G03127AL G94854LT G06110VR G55220VL G60145BJ G95368PR G47909JD G66538GV	GlyGen GlyConnect GlyConnect GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
FCERI mediated Ca+2 mobilization	Homo sapiens
FCERI mediated MAPK activation	Homo sapiens
FCERI mediated NF-kB activation	Homo sapiens
Fc epsilon receptor (FCERI) signaling	Homo sapiens
Interleukin-4 and Interleukin-13 signaling	Homo sapiens
Role of LAT2/NTAL/LAB on calcium mobilization	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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International Collaboration

Acknowledgements