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Galactose-binding lectin

Summary

Lectin Name Aliases

PNA
Peanut Agglutinin

Monosaccharide Specificities

Organism

Arachis hypogaea (peanut)

External Links

UniProt

P02872

LfDB

LfDB0172

UniLectin

P02872

CarboGrove

Annotation

Keyword

3D-structure
Calcium
Direct protein sequencing
Lectin
Manganese
Metal-binding
Signal

Gene Ontology (GO)

Displaying **all 2** entries
GO Term
carbohydrate binding
metal ion binding

Annotation information from UniProt.

Reference

Displaying entries **11 - 18** of 18 in total

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PubMed ID	Title	First Author
15210702	Peanut agglutinin high phenotype of activated CD8+ T cells results from de novo synthesis of CD45 glycans.	Amado M
15282210	Sialyltransferase mRNA abundances in B cells are strictly controlled, correlated with cognate lectin binding, and differentially responsive to immune signaling in vitro.	Marino JH
15814822	Mammalian-like nonsialyl complex-type N-glycosylation of equine gonadotropins in Mimic insect cells.	Legardinier S
15872151	Photoswitchable cluster glycosides as tools to probe carbohydrate-protein interactions: synthesis and lectin-binding studies of azobenzene containing multivalent sugar ligands.	Srinivas O
16571666	Peanut lectin stimulates proliferation of colon cancer cells by interaction with glycosylated CD44v6 isoforms and consequential activation of c-Met and MAPK: functional implications for disease-associated glycosylation changes.	Singh R
19073881	Systematic determination of the peptide acceptor preferences for the human UDP-Gal:glycoprotein-alpha-GalNAc beta 3 galactosyltransferase (T-synthase).	Perrine C
23275522	Cyclooxygenase-2 enzyme induces the expression of the α-2,3-sialyltransferase-3 (ST3Gal-I) in breast cancer.	Sproviero D
28973355	Lectin-binding characterizes the healthy human skeletal muscle glycophenotype and identifies disease-specific changes in dystrophic muscle.	McMorran BJ

Lectin Frontier DataBase (LfDB)

GlyTouCan: G75829VK
V-V₀: 64.26

GlyTouCan: G01434UY
V-V₀: 32.18

GlyTouCan: G57641IF
V-V₀: 22.93

LfDB provides quantitative interaction data in terms of the affinity constants (K_a) of a series of lectins toward a panel of pyridylaminated (PA) glycans obtained by an automated frontal affinity chromatography with fluorescence detection (FAC-FD) system. Since the data are accurate and reliable, providing the absolute values of sugar-protein interactions, LfDB would be a valuable resource in the studies of glycan-related biology.

The MCAW profile of the top three glycans above, which resulted from FAC analysis.

UniLectin

UniProt
P02872

CarboGrove

Lectin Name: Peanut Agglutinin
Common Name: PNA

Automated Analysis report (Top 10 high affinity glycans)

Array Source

CFG

Protein Source

Vector

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G71451AZ	1043.68	32.23
G64973KT	804.53	33.5
G74709RD	779.95	44.2
G01534TU	648.03	78.7
G00033MO	628.23	81.69
G21856LC	607.88	19.54
G11423ZI	572.88	19.25
G97494HI	563.98	15.01
G00031MO	421.29	18.42
G19687OL	301.97	19.71

GlyTouCan ID	Binding Intensity	Stdev
G97494HI	10867.13	694.93
G21856LC	8535.43	442.72
G64973KT	8473.06	505.37
G71451AZ	7792.53	494.86
G74709RD	6440.67	309.63
G11423ZI	6002.3	331.15
G00031MO	5691.41	278.56
G01534TU	5669.56	2759.03
G00033MO	5664.41	1267.94
G99053DY	4686.24	298.05

GlyTouCan ID	Binding Intensity	Stdev
G71451AZ	35803.25	1907.15
G21856LC	33399.38	1008.52
G97494HI	32474.43	2683.64
G11423ZI	32028.29	3019.25
G64973KT	30265.98	2347.61
G74709RD	29982.53	2376.46
G01534TU	29219.99	1123.89
G00033MO	29108.47	705.4
G09938IH	24475.02	1017.61
G48558GR	24013.39	1671.24

GlyTouCan ID	Binding Intensity	Stdev
G57604VY	45125.63	691.98
G80313NY	43864.44	1665
G05562YT	41274.81	7321.76
G14014EQ	39300.58	4888.35
G71451AZ	39258.94	1224.01
G99053DY	39167.24	16643.58
G95492XR	38405	2634.05
G64973KT	38105.82	1330.16
G00033MO	37644.74	654.37
G24142JB	36974.32	3261.8

CarboGrove View

Array Source

Microbial

Protein Source

Vector

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G27786ED	42428.5	5377.55
G84224TW	38970	709.94
G00031MO	35123.5	2088.09
G84224TW	34860	4007.88
G26425MP	33905.5	4683.17
G99053DY	31630	1243.09
G08772KU	23323.5	738.93
G26425MP	20941	2112.83
G34827IO	18326.5	242.54
G00049MO	12257.5	1610.08

GlyTouCan ID	Binding Intensity	Stdev
G27786ED	42428.5	5377.55
G84224TW	38970	709.94
G00031MO	35123.5	2088.09
G84224TW	34860	4007.88
G26425MP	33905.5	4683.17
G99053DY	31630	1243.09
G08772KU	23323.5	738.93
G26425MP	20941	2112.83
G34827IO	18326.5	242.54
G00049MO	12257.5	1610.08

CarboGrove View

Array Source

NCFG

Protein Source

Vector

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G71451AZ	14132	735
G97494HI	13647	2178
G74709RD	12881	1479
G00031MO	11330	667
G00033MO	11270	547
G64973KT	8218	395
G21856LC	6914	569
G00033MO	6503	1096
G01534TU	5546	827
G14014EQ	5337	597

GlyTouCan ID	Binding Intensity	Stdev
G71451AZ	33660	2599
G00033MO	31311	3023
G14014EQ	31191	985
G64973KT	30511	1231
G00031MO	30327	1584
G74709RD	29675	1802
G64050LH	29108	2961
G99053DY	28864	1310
G11457RF	27896	1059
G01534TU	27894	3510

CarboGrove View

Array Source

NGGM

Protein Source

Vector

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G41473XU	12286	0
G86522OD	1313	0
G44909WI	525	0
G01685IB	470	0
G95782RB	364	0
G88876JQ	149	0
G60956VN	135	0
G78509IY	94	0
G98602UY	53	0
G70851FQ	49	0

CarboGrove View

Array Source

NGGM-TM

Protein Source

Vector

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G41473XU	64968.5	250.88
G01685IB	784.5	186.13
G95782RB	373.5	117.38
G45827GY	301.75	100.03
G86522OD	56.25	25.14
G44909WI	32.25	13.52
G55205ZV	11.75	8.73
G88876JQ	11.75	5.5
G48061MK	11.5	4.93
G33888AF	10	6.48

CarboGrove View

Array Source

ZBiotech

Protein Source

Vector

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G41473XU	65505	0
G19298OA	65504.66	0
G46613JI	39682.83	0
G00031MO	24688.5	0
G00033MO	15382.83	0
G97612UN	10183.33	0
G74621DY	463.83	0
G74353FF	140	0
G00068MO	63.66	0
G47548GA	56	0

CarboGrove View

Array Source

ZBiotech

Protein Source

Vector

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G46613JI	20437.25	845.35
G74621DY	1103	342.24
G45827GY	530	68.59
G22490RY	452	101.82
G78436BB	430	26.87
G41078PD	389	41.72
G49725SZ	302.5	164.76
G19298OA	195.25	61.16
G65718MY	146.5	4.95
G04616ST	69	18.38

CarboGrove View

CarboGrove is populated with the results from 35 types of glycan arrays, 13 glycan families, 5 experimental methods, and 19 laboratories or companies by processing and interpreting data from various types of glycan arrays.