GlyCosmos Portal

Homo sapiens (human)

Summary

Taxonomy ID: 9606
PubChem Taxonomy: 9606

Genes (10109) Glycans (5831) Glycoproteins (15834) Lectins (297) Pathways (2074)

Displaying entries **76 - 100** of **2074** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol
VEGFR2 mediated vascular permeability	3-phosphoinositide-dependent protein kinase 1 Acyl-coenzyme A thioesterase THEM4 Cadherin-5 Calmodulin-1 Catenin alpha-1 Catenin beta-1 Catenin delta-1 Caveolin-1 Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 Heat shock protein HSP 90-alpha Junction plakoglobin Membrane protein Nitric oxide synthase 3 Nucleoprotein Proline-rich protein 5 Proto-oncogene vav RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Rapamycin-insensitive companion of mTOR Ras-related C3 botulinum toxin substrate 1 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 3 Serine/threonine-protein kinase mTOR Target of rapamycin complex 2 subunit MAPKAP1 Target of rapamycin complex subunit LST8 Tribbles homolog 3	O15530 O60716 O75914 P07900 P0DP23 P0DTC5 P0DTC9 P14923 P15498 P29474 P31749 P31751 P33151 P35221 P35222 P42345 P52735 P63000 P85299 Q03135 Q13153 Q13177 Q5T1C6 Q6R327 Q96RU7 Q9BPZ7 Q9BVC4 Q9UKW4 Q9Y243	AKT1 AKT2 AKT3 C20orf97 CALM CALM1 CAM CAM1 CAV CAV1 CDH5 CTMP CTNNA1 CTNNB CTNNB1 CTNND1 CTNNG DP3 FRAP FRAP1 FRAP2 GBL HSP90A HSP90AA1 HSPC1 HSPCA JUP KIAA0384 KIAA1999 LST8 M MAPKAP1 MIP1 MLST8 MTOR N NIPK NOS3 OPHN3 PAK1 PAK2 PAK3 PDK1 PDPK1 PKB PKBG PROTOR1 PRR5 RAC RAC1 RAFT1 RAPT1 RICTOR SIN1 SKIP3 TC25 THEM4 TRB3 TRIB3 VAV VAV1 VAV2 VAV3
RUNX2 regulates genes involved in cell migration	Collagenase 3 Core-binding factor subunit beta Integrin alpha-5 Integrin beta-like protein 1 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase	O95965 P08648 P31749 P31751 P45452 Q13951 Q9Y243	AKT1 AKT2 AKT3 CBFB FNRA ITGA5 ITGBL1 MMP13 OSCP PKB PKBG RAC TIED
LXRs regulate gene expression linked to triglyceride lipolysis in adipose	Oxysterols receptor LXR-alpha Oxysterols receptor LXR-beta Perilipin-1 Retinoic acid receptor RXR-alpha Retinoic acid receptor RXR-beta	O60240 P19793 P28702 P55055 Q13133	LXRA LXRB NER NR1H2 NR1H3 NR2B1 NR2B2 PERI PLIN PLIN1 RXRA RXRB UNR
ATF4 activates genes in response to endoplasmic reticulum stress	Asparagine synthetase [glutamine-hydrolyzing] C-C motif chemokine 2 CCAAT/enhancer-binding protein beta CCAAT/enhancer-binding protein gamma Cyclic AMP-dependent transcription factor ATF-3 Cyclic AMP-dependent transcription factor ATF-4 Cyclic AMP-dependent transcription factor ATF-6 alpha DNA damage-inducible transcript 3 protein Exosome complex component CSL4 Exosome complex component MTR3 Exosome complex component RRP40 Exosome complex component RRP41 Exosome complex component RRP42 Exosome complex component RRP43 Exosome complex component RRP45 Exosome complex component RRP46 Exosome complex component RRP4 Exosome complex exonuclease RRP44 Far upstream element-binding protein 2 Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein Insulin-like growth factor-binding protein 1 Interleukin-8 Nuclear transcription factor Y subunit alpha Nuclear transcription factor Y subunit beta Nuclear transcription factor Y subunit gamma Poly(A)-specific ribonuclease PARN m7GpppN-mRNA hydrolase	O95453 P08243 P08833 P10145 P13500 P17676 P18847 P18848 P18850 P23511 P25208 P35638 P53567 Q06265 Q13868 Q13952 Q15011 Q15024 Q5RKV6 Q8IU60 Q92945 Q96B26 Q9NPD3 Q9NQT4 Q9NQT5 Q9Y2L1 Q9Y3B2	ASNS ATF3 ATF4 ATF6 CCL2 CEBPB CEBPG CHOP CHOP10 CML28 CREB2 CSL4 CXCL8 DAN DCP2 DDIT3 DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FUBP2 GADD153 HAP3 HERP HERPUD1 IBP1 IGFBP1 IL8 KHSRP KIAA0025 KIAA0116 KIAA1008 MCP1 MIF1 MTR3 NFYA NFYB NFYC NUDT20 OIP2 PARN PMSCL1 RRP4 RRP40 RRP41 RRP42 RRP43 RRP44 RRP46 SCYA2 SKI6 TCF5 TS11 TXREB
Purine catabolism	5'(3')-deoxyribonucleotidase, cytosolic type 5'-nucleotidase 5-hydroxymethyl-dUMP N-hydrolase Cytosolic 5'-nucleotidase 1A Cytosolic 5'-nucleotidase 1B Cytosolic purine 5'-nucleotidase Guanine deaminase Inosine triphosphate pyrophosphatase Purine nucleoside phosphorylase Xanthine dehydrogenase/oxidase	O43598 P00491 P21589 P47989 P49902 Q8TCD5 Q96P26 Q9BXI3 Q9BY32 Q9Y2T3	AIRP C20orf37 C6orf108 DNPH1 DNT1 GDA ITPA KIAA1258 NP NT5 NT5B NT5C NT5C1A NT5C1B NT5C2 NT5CP NT5E NTE PNP PNT5 RCL UMPH2 XDH XDHA
Synthesis of PS	Phosphatidylserine synthase 1 Phosphatidylserine synthase 2	P48651 Q9BVG9	KIAA0024 PSS2 PSSA PTDSS1 PTDSS2
RPIA deficiency: failed conversion of R5P to RU5P	Ribose-5-phosphate isomerase	P49247	RPI RPIA
Respiratory syncytial virus genome replication	Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Nucleoprotein Phosphoprotein Protein M2-1 Protein M2-2 RNA-directed RNA polymerase L	P03418 P03421 P04545 P07900 P08238 P28887 P88812	HSP90A HSP90AA1 HSP90AB1 HSP90B HSPC1 HSPC2 HSPC3 HSPCA HSPCB L M2-1 M2-2 N P
Suppression of autophagy	Dual specificity protein phosphatase 16 N-acetyltransferase Eis Phosphatidylinositol-3-phosphatase Ras-related protein Rab-7a	O53361 P51149 P9WFK7 Q9BY84	DUSP16 KIAA1700 MKP7 RAB7 RAB7A eis sapM
Signaling by Retinoic Acid	Cellular retinoic acid-binding protein 2 Dihydrolipoyl dehydrogenase, mitochondrial Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Fatty acid-binding protein 5 Peroxisome proliferator-activated receptor delta Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial Pyruvate dehydrogenase E1 component subunit beta, mitochondrial Pyruvate dehydrogenase protein X component, mitochondrial Retinoic acid receptor RXR-alpha Retinoic acid receptor RXR-beta Retinoic acid receptor RXR-gamma Retinoic acid receptor alpha Retinoic acid receptor beta Retinoic acid receptor gamma [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	O00330 P08559 P09622 P10276 P10515 P10826 P11177 P13631 P19793 P28702 P29373 P29803 P48443 Q01469 Q03181 Q15118 Q15119 Q15120 Q16654	CRABP2 DLAT DLD DLTA FABP5 GCSL HAP LAD NR1B1 NR1B2 NR1B3 NR1C2 NR2B1 NR2B2 NR2B3 PDHA1 PDHA2 PDHAL PDHB PDHK1 PDHK2 PDHK3 PDHK4 PDHX PDK1 PDK2 PDK3 PDK4 PDX1 PHE1A PHE1B PHE3 PPARB PPARD RARA RARB RARG RXRA RXRB RXRG
ERKs are inactivated	Dual specificity protein phosphatase 3 Dual specificity protein phosphatase 4 Dual specificity protein phosphatase 6 Dual specificity protein phosphatase 7 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase 7 Serine/threonine-protein kinase VRK3 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	P27361 P28482 P30153 P30154 P51452 P62714 P67775 Q13115 Q13164 Q14738 Q16828 Q16829 Q8IV63	BMK1 DUSP3 DUSP4 DUSP6 DUSP7 ERK1 ERK2 ERK5 MAPK1 MAPK3 MAPK7 MKP2 MKP3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRKM1 PRKM2 PRKM3 PRKM7 PYST1 PYST2 VH2 VHR VRK3
Condensation of Prophase Chromosomes	Condensin-2 complex subunit D3 Condensin-2 complex subunit G2 Condensin-2 complex subunit H2 Cyclin-dependent kinase 1 G2/mitotic-specific cyclin-B1 Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.1t Histone H3.2 Histone H3.3 Histone H4 Microcephalin N-lysine methyltransferase KMT5A Protein SET Retinoblastoma-associated protein Serine/threonine-protein kinase PLK1 Structural maintenance of chromosomes protein 2 Structural maintenance of chromosomes protein 4	O60814 O95347 P04908 P06400 P06493 P06899 P0C5Y9 P14635 P16104 P20671 P23527 P33778 P42695 P53350 P57053 P58876 P62805 P62807 P68431 P84243 Q01105 Q16695 Q16777 Q16778 Q6FI13 Q6IBW4 Q71DI3 Q71UI9 Q86XI2 Q8N257 Q8NEM0 Q93077 Q93079 Q96A08 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9NQR1 Q9NTJ3	CAPC CAPD3 CAPE CAPH2 CCNB CCNB1 CDC2 CDC28A CDK1 CDKN1 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3-4 H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H3FT H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST3H3 HIST4H4 KIAA0056 KMT5A LUZP5 MCPH1 NCAPD3 NCAPG2 NCAPH2 P34CDC2 PLK PLK1 PRSET7 RB1 SET SET07 SET8 SETD8 SMC2 SMC2L1 SMC4 SMC4L1 TSH2B
Telomere C-strand (Lagging Strand) Synthesis	Adrenocortical dysplasia protein homolog DNA polymerase delta catalytic subunit DNA polymerase delta subunit 2 DNA polymerase delta subunit 3 DNA polymerase delta subunit 4 Proliferating cell nuclear antigen Protection of telomeres protein 1 TERF1-interacting nuclear factor 2 Telomeric repeat-binding factor 1 Telomeric repeat-binding factor 2-interacting protein 1 Telomeric repeat-binding factor 2	P12004 P28340 P49005 P54274 Q15054 Q15554 Q96AP0 Q9BSI4 Q9HCU8 Q9NUX5 Q9NYB0	ACD DRIP5 KIAA0039 PCNA PIN2 PIP1 POLD POLD1 POLD2 POLD3 POLD4 POLDS POT1 PTOP RAP1 TERF1 TERF2 TERF2IP TIN2 TINF2 TINT1 TPP1 TRBF1 TRBF2 TRF TRF1 TRF2
CLEC7A (Dectin-1) signaling	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 3-phosphoinositide-dependent protein kinase 1 B-cell lymphoma/leukemia 10 C-type lectin domain family 7 member A Caspase recruitment domain-containing protein 11 Caspase recruitment domain-containing protein 9 Cullin-1 F-box/WD repeat-containing protein 11 F-box/WD repeat-containing protein 1A Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta Mitogen-activated protein kinase kinase kinase 7 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 NF-kappa-B essential modulator NF-kappa-B inhibitor alpha Nuclear factor NF-kappa-B p105 subunit Polyubiquitin-B Polyubiquitin-C Proteasomal ubiquitin receptor ADRM1 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Protein kinase C delta type S-phase kinase-associated protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TNF receptor-associated factor 6 Transcription factor p65 Tyrosine-protein kinase SYK Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D2 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 R1 Ubiquitin-conjugating enzyme E2 variant 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00231 O00232 O00487 O14818 O14920 O15111 O15530 O43242 O43318 O95999 P0CG47 P0CG48 P16885 P17980 P19838 P20618 P25786 P25787 P25788 P25789 P25963 P28066 P28070 P28072 P28074 P35998 P43405 P43686 P48556 P49427 P49720 P49721 P51665 P51668 P60896 P60900 P61088 P62191 P62195 P62333 P62837 P62979 P62987 P63208 Q04206 Q05655 Q13200 Q13404 Q13616 Q15008 Q15750 Q16186 Q8N5C8 Q99436 Q99460 Q9BXL7 Q9BXN2 Q9H257 Q9NYJ8 Q9UDY8 Q9UKB1 Q9UNM6 Q9Y297 Q9Y4K3 Q9Y6K9	ADRM1 BCL10 BGR BLU BTRC BTRCP BTRCP2 C7orf76 CARD11 CARD9 CARMA1 CDC34 CHUK CIPER CLAP CLEC7A CLECSF12 CROC1 CUL1 DECTIN1 DSS1 EMC19 FBW1A FBW1B FBXW11 FBXW1A FBXW1B FIP3 GP110 HC2 HC3 HC8 HC9 HSPC IKBA IKBKB IKBKG IKKA IKKB KIAA0107 KIAA0696 KIAA0733 LMPX LMPY MAD3 MALT1 MAP3K7 MAP3K7IP1 MAP3K7IP2 MAP3K7IP3 MB1 MIP224 MLT MOV34L MSS1 NEMO NFKB1 NFKB3 NFKBI NFKBIA NU OCP2 PDK1 PDPK1 PFAAP4 PKCD PLCG2 POH1 PRKCD PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PUBC1 RELA RNF85 RPS27A SEM1 SFT SHFDG1 SHFM1 SKP1 SKP1A SUG1 SUG2 SYK TAB1 TAB2 TAB3 TAK1 TBP1 TBP7 TCEB1L TCF16 TRAF6 TRAP2 UBA52 UBA80 UBB UBC UBC4 UBC5A UBC5B UBCEP1 UBCEP2 UBCH3 UBCH4 UBCH5 UBCH5A UBCH5B UBE2D1 UBE2D2 UBE2N UBE2R1 UBE2V UBE2V1 UEV1 X Y Z
Glycosphingolipid biosynthesis	2-hydroxyacylsphingosine 1-beta-galactosyltransferase Alpha-2,8-sialyltransferase 8E Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Beta-1,3-galactosyltransferase 4 Beta-1,4 N-acetylgalactosaminyltransferase 1 Beta-1,4-galactosyltransferase 5 Beta-1,4-galactosyltransferase 6 CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 Ceramide glucosyltransferase Ceramide kinase Galactoside alpha-(1,2)-fucosyltransferase 1 Galactoside alpha-(1,2)-fucosyltransferase 2 Galactosylceramide sulfotransferase Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase Lactosylceramide 4-alpha-galactosyltransferase Lactosylceramide alpha-2,3-sialyltransferase UDP-GalNAc	O15466 O43286 O75752 O96024 P19526 Q00973 Q10981 Q11203 Q16739 Q16842 Q16880 Q8TCT0 Q969X2 Q99999 Q9BVH7 Q9BYG0 Q9NPC4 Q9UBX8 Q9UNP4	A14GALT A4GALT A4GALT1 B3GALNT1 B3GALT3 B3GALT4 B3GNT5 B4GALNT1 B4GALT5 B4GALT6 CERK CGT CST FUT1 FUT2 GAL3ST1 GALGT GALT4 H HSC KIAA1646 SEC2 SIAT2 SIAT4B SIAT6 SIAT7E SIAT7F SIAT8E SIAT9 ST3GAL2 ST3GAL3 ST3GAL5 ST6GALNAC5 ST6GALNAC6 ST8SIA5 UGCG UGT4 UGT8
Interleukin-35 Signalling	Calnexin Interleukin-12 receptor subunit beta-2 Interleukin-12 subunit alpha Interleukin-27 receptor subunit alpha Interleukin-27 subunit beta Interleukin-6 receptor subunit beta Non-receptor tyrosine-protein kinase TYK2 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 4 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2	O60674 P23458 P27824 P29459 P29597 P40189 P40763 P42224 Q14213 Q14765 Q6UWB1 Q99665	APRF CANX CRL1 EBI3 IL12A IL12RB2 IL27B IL27RA IL6ST JAK1 JAK1A JAK1B JAK2 NKSF1 STAT1 STAT3 STAT4 TCCR TYK2 WSX1
NIK-->noncanonical NF-kB signaling	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cullin-1 F-box/WD repeat-containing protein 11 F-box/WD repeat-containing protein 1A Inhibitor of nuclear factor kappa-B kinase subunit alpha Mitogen-activated protein kinase kinase kinase 14 NEDD8-activating enzyme E1 catalytic subunit NEDD8-conjugating enzyme Ubc12 Nuclear factor NF-kappa-B p100 subunit Polyubiquitin-B Polyubiquitin-C Proteasomal ubiquitin receptor ADRM1 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 S-phase kinase-associated protein 1 Transcription factor RelB Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00231 O00232 O00487 O14818 O15111 O43242 P0CG47 P0CG48 P17980 P20618 P25786 P25787 P25788 P25789 P28066 P28070 P28072 P28074 P35998 P43686 P48556 P49720 P49721 P51665 P60896 P60900 P61081 P62191 P62195 P62333 P62979 P62987 P63208 Q00653 Q01201 Q13200 Q13616 Q15008 Q16186 Q8TBC4 Q99436 Q99460 Q99558 Q9UKB1 Q9UNM6 Q9Y297	ADRM1 BTRC BTRCP BTRCP2 C7orf76 CHUK CUL1 DSS1 EMC19 FBW1A FBW1B FBXW11 FBXW1A FBXW1B GP110 HC2 HC3 HC8 HC9 HSPC IKKA KIAA0107 KIAA0696 LMPX LMPY LYT10 MAP3K14 MB1 MIP224 MOV34L MSS1 NFKB2 NIK NU OCP2 PFAAP4 POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 RELB RPS27A SEM1 SHFDG1 SHFM1 SKP1 SKP1A SUG1 SUG2 TBP1 TBP7 TCEB1L TCF16 TRAP2 UBA3 UBA52 UBA80 UBB UBC UBC12 UBCEP1 UBCEP2 UBE1C UBE2M X Y Z
Presynaptic phase of homologous DNA pairing and strand exchange	26S proteasome complex subunit SEM1 ATR-interacting protein BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein Cell cycle checkpoint control protein RAD9A Cell cycle checkpoint control protein RAD9B Cell cycle checkpoint protein RAD17 Cell cycle checkpoint protein RAD1 Checkpoint protein HUS1 DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 2-binding protein 1 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Serine-protein kinase ATM Serine/threonine-protein kinase ATR Serine/threonine-protein kinase Chk1	O14757 O15315 O43502 O43543 O60671 O60921 O60934 O75771 O75943 P15927 P27694 P35244 P35249 P35250 P38398 P40937 P40938 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q13535 Q14191 Q6WBX8 Q8WXE1 Q92547 Q92878 Q92993 Q96E14 Q99638 Q99708 Q99728 Q9BSD3 Q9BX63 Q9H9A7 Q9UQ84	AGS1 ATM ATR ATRIP BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C12orf32 C16orf75 C7orf76 C9orf76 CHEK1 CHK1 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FRP1 HEX1 HNGS1 HTATIP HUS1 KAT5 KIAA0083 KIAA0259 MRE11 MRE11A NBN NBS NBS1 P95 R24L RAD1 RAD17 RAD50 RAD51 RAD51A RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RAD9A RAD9B RBBP8 REC1 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 REPA1 REPA2 REPA3 RFC2 RFC3 RFC4 RFC5 RHINO RHNO1 RMI1 RMI2 RNF53 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A TOPBP1 WRN XRCC2
Negative regulation of the PI3K/AKT network	Acyl-coenzyme A thioesterase THEM4 PH domain leucine-rich repeat-containing protein phosphatase 1 PH domain leucine-rich repeat-containing protein phosphatase 2 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Tribbles homolog 3	O60346 P31749 P31751 P60484 Q5T1C6 Q6ZVD8 Q96RU7 Q9Y243	AKT1 AKT2 AKT3 C20orf97 CTMP KIAA0606 KIAA0931 MMAC1 NIPK PHLPP PHLPP1 PHLPP2 PHLPPL PKB PKBG PLEKHE1 PTEN RAC SCOP SKIP3 TEP1 THEM4 TRB3 TRIB3
SHC1 events in EGFR signaling	Amphiregulin Epidermal growth factor receptor Epigen GTPase HRas GTPase NRas Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protransforming growth factor alpha SHC-transforming protein 1 Son of sevenless homolog 1	O14944 P00533 P01111 P01112 P01133 P01135 P15514 P29353 P35070 Q07889 Q6UW88 Q99075	AREG AREGB BTC DTR DTS EGF EGFR EPGN ERBB ERBB1 EREG HBEGF HEGFL HER1 HRAS HRAS1 NRAS SDGF SHC SHC1 SHCA SOS1 TGFA
Nuclear events stimulated by ALK signaling in cancer	Bcl-2-related protein A1 CCAAT/enhancer-binding protein beta Cullin-1 DNA (cytosine-5)-methyltransferase 1 E3 ubiquitin-protein ligase RBX1 Forkhead box protein M1 G2/mitotic-specific cyclin-B1 Granzyme B Helicase MOV-10 Histone deacetylase 1 Inducible T-cell costimulator Interferon regulatory factor 4 Interleukin-10 receptor subunit alpha Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Nucleophosmin Perforin-1 Protein argonaute-1 Protein argonaute-2 Protein argonaute-3 Protein argonaute-4 Retinoblastoma-associated protein S-phase kinase-associated protein 1 Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Small ribosomal subunit protein eS6 Transcription factor JunB Trinucleotide repeat-containing gene 6C protein Twist-related protein 1 Tyrosine-protein kinase ZAP-70 Tyrosine-protein phosphatase non-receptor type 6 Zinc finger C3HC-type protein 1	P06400 P06748 P10144 P14222 P14635 P17275 P17676 P26358 P27361 P28482 P29350 P40763 P42229 P43403 P62753 P62877 P63208 Q08050 Q13547 Q13616 Q13651 Q15306 Q15672 Q16548 Q86WB0 Q9H9G7 Q9HCE1 Q9HCJ0 Q9HCK5 Q9UKV8 Q9UL18 Q9Y6W8	AGO1 AGO2 AGO3 AGO4 AILIM AIM APRF BCL2A1 BCL2L5 BFL1 BHLHA38 CCNB CCNB1 CEBPB CGL1 CSPB CTLA1 CUL1 CXXC9 DNMT DNMT1 EIF2C1 EIF2C2 EIF2C3 EIF2C4 EMC19 ERK1 ERK2 FKHL16 FOXM1 GRB GRS GZMB HBPA1 HCP HDAC1 HFH11 ICOS IL10R IL10RA IRF4 JUNB KIAA1567 KIAA1582 KIAA1631 MAPK1 MAPK3 MOV10 MPP2 MUM1 NIPA NPM NPM1 OCP2 PFP PRF1 PRKM1 PRKM2 PRKM3 PTP1C PTPN6 RB1 RBX1 RNF75 ROC1 RPD3L1 RPS6 SKP1 SKP1A SRK STAT3 STAT5 STAT5A TCEB1L TCF5 TNRC6C TWIST TWIST1 WIN ZAP70 ZC3HC1
rRNA modification in the mitochondrion	5-methylcytosine rRNA methyltransferase NSUN4 Dimethyladenosine transferase 1, mitochondrial Transcription termination factor 4, mitochondrial rRNA methyltransferase 1, mitochondrial rRNA methyltransferase 2, mitochondrial rRNA methyltransferase 3, mitochondrial	Q6IN84 Q7Z6M4 Q8WVM0 Q96CB9 Q9HC36 Q9UI43	FJH1 FTSJ2 MRM1 MRM2 MRM3 MTERF4 MTERFD2 NSUN4 RNMTL1 TFB1M
Regulation of KIT signaling	E3 ubiquitin-protein ligase CBL Mast/stem cell growth factor receptor Kit Protein kinase C alpha type SH2B adapter protein 2 SH2B adapter protein 3 Son of sevenless homolog 1 Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 6 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein kinase Lyn Tyrosine-protein kinase Yes Tyrosine-protein phosphatase non-receptor type 6	O14492 O14544 O15524 P06239 P06241 P07947 P07948 P10721 P17252 P22681 P29350 Q07889 Q9UQQ2	APS CBL CBL2 CIS4 FYN HCP JTK8 KIT LCK LNK LYN PKCA PRKACA PRKCA PTP1C PTPN6 RNF55 SCFR SH2B2 SH2B3 SOCS1 SOCS4 SOCS6 SOS1 SSI1 TIP3 YES YES1
Activation of Matrix Metalloproteinases	72 kDa type IV collagenase Cathepsin G Cathepsin K Cathepsin L2 Chymase Chymotrypsinogen B2 Chymotrypsinogen B Collagen alpha-1(XVIII) chain Collagenase 3 Furin Interstitial collagenase Kallikrein-2 Matrilysin Matrix metalloproteinase-14 Matrix metalloproteinase-15 Matrix metalloproteinase-16 Matrix metalloproteinase-17 Matrix metalloproteinase-24 Matrix metalloproteinase-25 Matrix metalloproteinase-9 Metalloproteinase inhibitor 1 Metalloproteinase inhibitor 2 Neutrophil collagenase Neutrophil elastase Plasma kallikrein Plasminogen Serine protease 1 Stromelysin-1 Stromelysin-2 Stromelysin-3 Testican-3 Trypsin-2 Tryptase alpha/beta-1	O60911 P00747 P01033 P03952 P03956 P07477 P07478 P08246 P08253 P08254 P08311 P09237 P09238 P09958 P14780 P16035 P17538 P20151 P22894 P23946 P24347 P39060 P43235 P45452 P50281 P51511 P51512 Q15661 Q6GPI1 Q9BQ16 Q9NPA2 Q9ULZ9 Q9Y5R2	C8orf57 CATL2 CLG CLG1 CLG4A CLG4B CLGI CMA1 COL18A1 CTRB CTRB1 CTRB2 CTSG CTSK CTSL2 CTSO CTSO2 CTSU CTSV CYH CYM ELA2 ELANE FUR FURIN KLK2 KLK3 KLKB1 MMP1 MMP10 MMP11 MMP13 MMP14 MMP15 MMP16 MMP17 MMP2 MMP20 MMP24 MMP25 MMP3 MMP7 MMP8 MMP9 MMPL1 MMPX2 MPSL1 MT4MMP MT5MMP MT6MMP PACE PCSK3 PLG PRSS1 PRSS2 PUMP1 SPOCK3 STMY1 STMY2 STMY3 TICN3 TIMP TIMP1 TIMP2 TPS1 TPS2 TPSAB1 TPSB1 TRP1 TRY1 TRY2 TRYP1 TRYP2
Constitutive Signaling by Aberrant PI3K in Cancer	Amphiregulin B-lymphocyte antigen CD19 BDNF/NT-3 growth factors receptor Beta-klotho Brain-derived neurotrophic factor Epidermal growth factor receptor Epigen Estrogen receptor beta Estrogen receptor Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fms-related tyrosine kinase 3 ligand GRB2-associated-binding protein 1 GRB2-associated-binding protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Insulin receptor substrate 1 Insulin receptor substrate 2 Mast/stem cell growth factor receptor Kit NT-3 growth factor receptor Neurotrophin-3 Neurotrophin-4 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Phosphoinositide 3-kinase adapter protein 1 Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit B Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Proto-oncogene tyrosine-protein kinase Src Proto-oncogene vav Protransforming growth factor alpha Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 2 Receptor tyrosine-protein kinase erbB-2 Receptor-type tyrosine-protein kinase FLT3 Rho-related GTP-binding protein RhoG Striatin T-cell receptor-associated transmembrane adapter 1 T-cell-specific surface glycoprotein CD28 T-lymphocyte activation antigen CD80 T-lymphocyte activation antigen CD86 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein phosphatase non-receptor type 11	O00329 O00459 O14511 O14944 O15520 O43320 O43815 O76093 O95750 P00533 P01127 P01133 P01135 P03372 P04626 P05230 P06239 P06241 P08581 P08620 P09038 P09619 P10721 P10747 P10767 P11487 P12931 P14210 P15153 P15391 P15498 P15514 P16234 P20783 P21781 P22455 P23560 P27986 P31371 P33681 P34130 P35070 P35568 P36888 P42081 P42336 P42338 P49771 P56975 P63000 P84095 Q02297 Q06124 Q13480 Q16288 Q16620 Q6PIZ9 Q6UW88 Q6ZUJ8 Q86Z14 Q8WU20 Q8WWG1 Q92569 Q92731 Q99075 Q9GZV9 Q9HCT0 Q9NP95 Q9UQC2 Q9Y4H2	AREG AREGB ARHG BCAP BDNF BTC CD135 CD19 CD28 CD28LG CD28LG1 CD28LG2 CD80 CD86 DTR DTS EGF EGFR EPGN ERBB ERBB1 ERBB2 EREG ESR ESR1 ESR2 ESTRB FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FGFR4 FLK2 FLT3 FLT3LG FRS2 FYN GAB1 GAB2 GGF GRB1 HBEGF HEGFL HER1 HER2 HGF HGL HPTA HRGA HST HST2 HSTF1 HSTF2 HYPF INT2 IRS1 IRS2 JTK2 KGF KIAA0571 KIT KLB KS3 LAB7 LCK MET MLN19 NDF NEU NGL NR3A1 NR3A2 NRG1 NRG2 NRG3 NRG4 NTAK NTF3 NTF4 NTF5 NTRK2 NTRK3 PDGF2 PDGFB PDGFR PDGFR1 PDGFR2 PDGFRA PDGFRB PIK3AP1 PIK3C1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTP2C PTPN11 RAC1 RAC2 RHEPDGFRA RHOG SCFR SDGF SHPTP2 SIS SMDF SRC SRC1 STK1 STRN TC25 TCRIM TGFA TKF TRAT1 TRKB TRKC VAV VAV1

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